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  • 1
    Online Resource
    Online Resource
    Circumferential Pulmonary Vein Isolation With vs Without Additional Low-Voltage-Area Ablation in Older Patients With Paroxysmal Atrial Fibrillation : A Randomized Clinical Trial
    American Medical Association (AMA) ; 2023
    In:  JAMA Cardiology Vol. 8, No. 8 ( 2023-08-01), p. 765-
    Details
    In: JAMA Cardiology, American Medical Association (AMA), Vol. 8, No. 8 ( 2023-08-01), p. 765-
    Abstract: The overall success rate of circumferential pulmonary vein isolation (CPVI) treatment in patients with paroxysmal atrial fibrillation (AF) remains suboptimal, especially in older patients. Objective To explore the incremental benefit of low-voltage-area ablation after CPVI in older patients with paroxysmal AF. Design, Setting, and Participants This randomized clinical trial was an investigator-initiated trial to compare the efficacy of additional low-voltage-area ablation beyond CPVI vs CPVI alone in older patients with paroxysmal AF. Participants were patients aged 65 to 80 years with paroxysmal AF who were referred for catheter ablation. They were enrolled in 14 tertiary hospitals in China from April 1, 2018, to August 3, 2020, and follow-up occurred through August 15, 2021. Interventions Patients were randomized (1:1) to undergo CPVI plus low-voltage-area ablation or CPVI alone. Low-voltage areas were defined as areas with amplitude less than 0.5 mV in more than 3 adjacent points. If low-voltage areas existed, additional substrate ablation was performed in the CPVI plus group but not the CPVI alone group. Main Outcomes and Measures The primary end point of the study was freedom from atrial tachyarrhythmia as documented by electrocardiogram during a clinical visit or lasting longer than 30 seconds during Holter recordings occurring after a single ablation procedure. Results Among 438 patients who were randomized (mean [SD] age, 70.5 [4.4] years; 219 men [50%]), 24 (5.5%) did not complete the blanking period and were not included for efficacy analysis. After a median follow-up of 23 months, the recurrence rate of atrial tachyarrhythmia was significantly lower in the CPVI plus group (31/209 patients, 15%) compared with the CPVI alone group (49/205, 24%; hazard ratio [HR] , 0.61; 95% CI, 0.38-0.95; P  = .03). In subgroup analyses, among all patients with low-voltage area, CPVI plus substrate modification was associated with a 51% decreased risk of ATA recurrence compared with CPVI alone (HR, 0.49; 95% CI, 0.25-0.94; P  = .03). Conclusions and Relevance This study found that additional low-voltage-area ablation beyond CPVI decreased the ATA recurrence in older patients with paroxysmal AF compared with CPVI alone. Our findings merit further replication by larger trials with longer follow-up. Trial Registration ClinicalTrials.gov Identifier: NCT03462628
    Type of Medium: Online Resource
    ISSN: 2380-6583
    URL: Article
    DOI: 10.1001/jamacardio.2023.1749
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2023
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  • 2
    Online Resource
    Online Resource
    Identification of microRNAs in developing wheat grain that are potentially involved in regulating grain characteristics and the response to nitrogen levels
    Springer Science and Business Media LLC ; 2020
    In:  BMC Plant Biology Vol. 20, No. 1 ( 2020-12)
    Details
    In: BMC Plant Biology, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Abstract: MicroRNAs (miRNAs) play crucial roles in the regulation of plant development and growth, but little information is available concerning their roles during grain development under different nitrogen (N) application levels. Our objective was to identify miRNAs related to the regulation of grain characteristics and the response to different N fertilizer conditions. Results A total of 79 miRNAs (46 known and 33 novel miRNAs) were identified that showed significant differential expression during grain development under both high nitrogen (HN) and low nitrogen (LN) treatments. The miRNAs that were significantly upregulated early in grain development target genes involved mainly in cell differentiation, auxin-activated signaling, and transcription, which may be associated with grain size; miRNAs abundant in the middle and later stages target genes mainly involved in carbohydrate and nitrogen metabolism, transport, and kinase activity and may be associated with grain filling. Additionally, we identified 50 miRNAs (22 known and 28 novel miRNAs), of which 11, 9, and 39 were differentially expressed between the HN and LN libraries at 7, 17, and 27 days after anthesis (DAA). The miRNAs that were differentially expressed in response to nitrogen conditions target genes involved mainly in carbohydrate and nitrogen metabolism, the defense response, and transport as well as genes that encode ubiquitin ligase. Only one novel miRNA (PC-5p-2614_215) was significantly upregulated in response to LN treatment at all three stages, and 21 miRNAs showed significant differential expression between HN and LN conditions only at 27 DAA. We therefore propose a model for target gene regulation by miRNAs during grain development with N-responsive patterns. Conclusions The potential targets of the identified miRNAs are related to various biological processes, such as carbohydrate/nitrogen metabolism, transcription, cellular differentiation, transport, and defense. Our results indicate that miRNA-mediated networks, via posttranscriptional regulation, play crucial roles in grain development and the N response, which determine wheat grain weight and quality. Our study provides useful information for future research of regulatory mechanisms that focus on improving grain yield and quality.
    Type of Medium: Online Resource
    ISSN: 1471-2229
    URL: Article
    DOI: 10.1186/s12870-020-2296-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2059868-3
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Coordination of carbon and nitrogen accumulation and translocation of winter wheat plant to improve grain yield and processing quality
    Springer Science and Business Media LLC ; 2020
    In:  Scientific Reports Vol. 10, No. 1 ( 2020-06-25)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2020-06-25)
    Abstract: The objective of this work was to characterize the accumulation of carbon (C) and nitrogen (N), and the translocation of wheat ( Triticum aestivum L.) cultivars to achieve both high-quality and high-yield. Twenty-four wheat cultivars, including 12 cultivars containing high-quality gluten subunit 5 + 10 at Glu-D1 , and 12 cultivars with no Glu - D1 5 + 10, were planted at Yuanyang and Xuchang in Henan Province, during 2016–2017, and 2017–2018 cropping seasons. Wheat cultivars containing Glu-D1 5 + 10 had an advantage in grain quality traits. Significant difference ( P   〈  0.05) was observed for grain protein concentration (GPC) between 5 + 10 group and no 5 + 10 group. Grain yield (GY) was significantly correlated with kernel number (KN) (r = 0.778, P   〈  0.01), thousand-kernel weight (TKW) (r = 0.559, P   〈  0.01), dry matter accumulation at post-anthesis (r = 0.443, P   〈  0.05), and stem water-soluble carbohydrate (WSC) accumulation (r = 0.487, P   〈  0.05) and translocation amount (r = 0.490, P   〈  0.05). GPC, dough stability time (DST) and nitrogen agronomic efficiency (NAE) were significantly correlated with nitrogen accumulation (NAA) at maturity stage (r = 0.524, = 0.404, = 0.418, P   〈  0.01,  〈  0.05,  〈  0.05, respectively), and nitrogen translocation amount (r = 0.512, = 0.471, = 0.405, P   〈  0.05,  〈  0.05,  〈  0.05, respectively). These results suggest that good-quality, high-yield, and high-efficiency could achieve through the selection of high-quality wheat cultivars and coordination of C and N accumulation and translocation. High-quality gluten subunit gene Glu-D1 5 + 10 and stem WSC could be used as a selection index for breeding and production of high-quality and high-yield wheat.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-020-67343-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2615211-3
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  • 4
    Online Resource
    Online Resource
    The identification of the metabolites of chlorothalonil in zebrafish (Danio rerio) and their embryo toxicity and endocrine effects at environmentally relevant levels
    Elsevier BV ; 2016
    In:  Environmental Pollution Vol. 218 ( 2016-11), p. 8-15
    Details
    In: Environmental Pollution, Elsevier BV, Vol. 218 ( 2016-11), p. 8-15
    Type of Medium: Online Resource
    ISSN: 0269-7491
    URL: Article
    DOI: 10.1016/j.envpol.2016.08.026
    RVK:
    AR 10100
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 280652-6
    detail.hit.zdb_id: 2013037-5
    SSG: 12
    SSG: 14
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  • 5
    Online Resource
    Online Resource
    Microstructure of HIPed and SPSed 9Cr-ODS steel and its effect on helium bubble formation
    Elsevier BV ; 2016
    In:  Journal of Nuclear Materials Vol. 474 ( 2016-06), p. 65-75
    Details
    In: Journal of Nuclear Materials, Elsevier BV, Vol. 474 ( 2016-06), p. 65-75
    Type of Medium: Online Resource
    ISSN: 0022-3115
    URL: Article
    DOI: 10.1016/j.jnucmat.2016.03.010
    RVK:
    UQ 7360
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 2001279-2
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  • 6
    Online Resource
    Online Resource
    Feedback Control Architecture and Design Methodology for Service Delay Guarantees in Web Servers
    Institute of Electrical and Electronics Engineers (IEEE) ; 2006
    In:  IEEE Transactions on Parallel and Distributed Systems Vol. 17, No. 9 ( 2006-9), p. 1014-1027
    Details
    In: IEEE Transactions on Parallel and Distributed Systems, Institute of Electrical and Electronics Engineers (IEEE), Vol. 17, No. 9 ( 2006-9), p. 1014-1027
    Type of Medium: Online Resource
    ISSN: 1045-9219
    URL: Article
    DOI: 10.1109/TPDS.2006.123
    RVK:
    SQ 1100
    RVK:
    SA 1000
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2006
    detail.hit.zdb_id: 2027774-X
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    Online Resource
  • 7
    Online Resource
    Online Resource
    Nanoscale p-n heterojunctions of BiOI/nitrogen-doped reduced graphene oxide as a high performance photocatalyst
    Elsevier BV ; 2018
    In:  Carbon Vol. 132 ( 2018-06), p. 191-198
    Details
    In: Carbon, Elsevier BV, Vol. 132 ( 2018-06), p. 191-198
    Type of Medium: Online Resource
    ISSN: 0008-6223
    URL: Article
    DOI: 10.1016/j.carbon.2018.02.038
    RVK:
    VA 1120
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2014715-6
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  • 8
    Online Resource
    Online Resource
    The role of surgery type in postoperative atrial fibrillation and in-hospital mortality in esophageal cancer patients with preserved left ventricular ejection fraction
    Springer Science and Business Media LLC ; 2020
    In:  World Journal of Surgical Oncology Vol. 18, No. 1 ( 2020-12)
    Details
    In: World Journal of Surgical Oncology, Springer Science and Business Media LLC, Vol. 18, No. 1 ( 2020-12)
    Abstract: Postoperative atrial fibrillation (POAF) is one of the most common complications of esophagectomy, which may extend the inpatient hospital stay. Minimally invasive esophagectomy (MIE) has been increasingly used in clinical practice; however, its POAF risk and short-term mortality remain unclear. This study aimed to examine the POAF risk and in-hospital mortality rate between patients receiving MIE and open esophagectomy (OE). Methods Esophageal cancer patients who underwent MIE or OE from a retrospective cohort study were evaluated. A multivariate logistic regression model was built to assess the associations between esophagectomy (MIE vs. OE) and various outcomes (POAF, in-hospital mortality). Covariates included age, sex, body mass index, neoadjuvant therapy, tumor stage, surgery incision type, comorbidities, cardia conditions, peri-operative medication, and complications. Results Of the 484 patients with esophageal cancer, 63 received MIE. A total of 53 patients developed POAF. Compared to patients receiving OE, MIE patients had 81% reduced odds of POAF (adjusted odds ratio [aOR] 0.185, 95% CI 0.039–0.887, P = 0.035). No statistically significant association was found for in-hospital mortality (aOR 0.709, 95% CI 0.114–4.409, P = 0.712). Conclusions MIE is associated with a lower risk of POAF, compared to traditional surgery. No significant short-term survival benefit was found for MIE.
    Type of Medium: Online Resource
    ISSN: 1477-7819
    URL: Article
    DOI: 10.1186/s12957-020-02011-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2118383-1
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  • 9
    Online Resource
    Online Resource
    Novel anti-hyperuricemic hexapeptides derived from Apostichopus japonicus hydrolysate and their modulation effects on the gut microbiota and host microRNA profile
    Royal Society of Chemistry (RSC) ; 2022
    In:  Food & Function Vol. 13, No. 7 ( 2022), p. 3865-3878
    Details
    In: Food & Function, Royal Society of Chemistry (RSC), Vol. 13, No. 7 ( 2022), p. 3865-3878
    Abstract: Hyperuricemia (HUA) is the second most common metabolic disease nowadays, and is characterized by permanently increased concentrations of serum uric acid. In this study, two novel hexapeptides (GPAGPR and GPSGRP) were identified from Apostichopus japonicus hydrolysate and predicted to have xanthine oxidase (XOD) inhibitory activity by molecular docking. Their in vitro XOD inhibition rates reached 37.3% and 48.6%, respectively, at a concentration of 40 mg mL −1 . Subsequently, in vivo experiments were carried out in a HUA mouse model, and we found that both peptides reduced the serum uric acid by inhibiting uric acid biosynthesis and reabsorption, as well as alleviated renal inflammation via suppressing the activation of the NLRP3 inflammasome. 16S rDNA sequencing indicated that both peptide treatments reduced the richness and diversity of the gut microbiota, altered the composition in the phylum and genus levels, but different change trends were observed in the phylum Verrucomicrobia and genera Akkermansia , Dubosiella , Alloprevotella , Clostridium unclassified and Alistipes . In addition, changes in the renal microRNA (miRNA) profiles induced by GPSGRP treatment were analyzed; 21 differentially expressed (DE) miRNAs were identified among groups, and KEGG pathway analysis indicated that their potential target genes were involved in pluripotency of stem cell regulation, mTOR signaling pathway and proteoglycans. Moreover, ten miRNAs involved in the HUA onset and alleviation were identified, which showed a high correlation with genera related to the metabolism of short-chain fatty acids, bile acids and tryptophan. This study delineated two hexapeptides as potential microbiota modulators and miRNA regulators that can ameliorate HUA.
    Type of Medium: Online Resource
    ISSN: 2042-6496 , 2042-650X
    URL: Article
    DOI: 10.1039/D1FO03981D
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2022
    detail.hit.zdb_id: 2578152-2
    SSG: 21
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  • 10
    Online Resource
    Online Resource
    Mesenchymal stromal cells pretreated with proinflammatory cytokines enhance skin wound healing via IL-6-dependent M2 polarization
    Springer Science and Business Media LLC ; 2022
    In:  Stem Cell Research & Therapy Vol. 13, No. 1 ( 2022-08-13)
    Details
    In: Stem Cell Research & Therapy, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2022-08-13)
    Abstract: Numerous studies have shown that mesenchymal stromal cells (MSCs) promote cutaneous wound healing via paracrine signaling. Our previous study found that the secretome of MSCs was significantly amplified by treatment with IFN-γ and TNF-α (IT). It has been known that macrophages are involved in the initiation and termination of inflammation, secretion of growth factors, phagocytosis, cell proliferation, and collagen deposition in wound, which is the key factor during wound healing. In this study, we aim to test whether the supernatant of MSCs pretreated with IT (S-IT MSCs) possesses a more pronounced effect on improving wound healing and describe the interplay between S-IT MSCs and macrophages as well as the potential mechanism in skin wound healing. Methods In the present study, we used a unique supernatant of MSCs from human umbilical cord-derived MSCs (UC-MSCs) pretreated with IT, designated S-IT MSCs, subcutaneously injected into a mice total skin excision. We evaluated the effect of S-IT MSCs on the speed and quality of wound repair via IT MSCs-derived IL-6-dependent M2 polarization in vivo by hematoxylin–eosin staining (H & E), immunohistochemistry (IHC), immunofluorescence (IF), Masson’s trichrome staining, Sirius red staining, quantitative real-time PCR (qPCR). In addition, the effect of S-IT MSCs on the polarization of macrophages toward M2 phenotype and the potential mechanism of it were also investigated in vitro by flow cytometry (FCM), enzyme-linked immunosorbent assay (ELISA), tube formation assay, and western blot analysis. Results Compared with control supernatant (S-MSCs), our H & E and IF results showed that S-IT MSCs were more effectively in promoting macrophages convert to the M2 phenotype and enhancing phagocytosis of M2 macrophages. Meanwhile, the results of tube formation assay, IHC, Masson’s trichrome staining, Sirius red staining showed that the abilities of M2 phenotype to promote vascularization and collagen deposition were significantly enhanced by S-IT MSCs-treated, thereby accelerating higher quality wound healing. Further, our ELISA, FCM, qPCR and western blot results showed that IL-6 was highly enriched in S-IT MSCs and acted as a key regulator to induce macrophages convert to the M2 phenotype through IL-6-dependent signaling pathways, ultimately achieving the above function of promoting wound repair. Conclusions These findings provide the first evidence that the S-IT MSCs is more capable of eliciting M2 polarization of macrophages via IL-6-dependent signaling pathways and accelerating wound healing, which may represent a new strategy for optimizing the therapeutic effect of MSCs on wound healing.
    Type of Medium: Online Resource
    ISSN: 1757-6512
    URL: Article
    DOI: 10.1186/s13287-022-02934-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2548671-8
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