In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 156, No. 2 ( 2007-02), p. 257-261
Abstract:
Objective : Tissue inhibitor of metalloproteinase (TIMP)-1 is upregulated in fat of obese rodents and promotes adipose tissue development in these animals. However, it is unclear whether TIMP-1 independently predicts adiposity in humans and whether serum levels are increased in s.c. and visceral obesity. Design : Twenty-four lean, 16 s.c. obese, and 20 visceral obese subjects were studied. Methods : Plasma TIMP-1 concentrations were quantified using ELISAs and correlated to clinical parameters. Results : Plasma TIMP-1 levels were significantly different between lean (156 ± 42 μg/l), s.c. obese (186 ± 52 μg/l), and visceral obese (198 ± 42 μg/l) subjects ( P 〈 0.01). Furthermore, TIMP-1 correlated positively with body mass index (BMI), waist-to-hip ratio (WHR), % body fat, fasting insulin, free fatty acids, cholesterol, leptin, interleukin-6, and negatively with adiponectin ( P 〈 0.05). Moreover, TIMP-1 serum levels predicted % body fat but not WHR independent of age, sex, and plasma insulin. Conclusions : We demonstrate that increased TIMP-1 serum levels are found with increased adiposity in humans.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
2007
detail.hit.zdb_id:
1485160-X
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