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  • 1
    Online Resource
    Online Resource
    Spectral analysis of the rapid eye movement sleep electroencephalogram in right and left temporal regions: A biological marker of Alzheimer's disease
    Wiley ; 1992
    In:  Annals of Neurology Vol. 32, No. 2 ( 1992-08), p. 172-176
    Details
    In: Annals of Neurology, Wiley, Vol. 32, No. 2 ( 1992-08), p. 172-176
    Abstract: Spectral analysis of electroencephalograms (EEGs) for both wakefulness and rapid eye movement (REM) sleep was performed over the temporal regions in 8 patients with mild to moderate Alzheimer's disease and in 8 age‐matched control subjects. EEG slowing in Alzheimer patients was found to be much more prominent during REM sleep than during wakefulness. In addition, asymmetry on the awake EEG of Alzheimer patients was found to be even more prominent than on the REM sleep EEG. When EEG values of the most impaired hemisphere during REM sleep were examined, no overlap was found between the two groups either for the ratio of slow to fast frequencies or for percent power of each of the frequency bands. This was not the case for the awake EEG. These results suggest that diagnostically meaningful cutoff values for discriminating patients with mild to moderate Alzheimer's disease from age‐matched control subjects can be derived from the REM sleep EEG of the temporal lobe.
    Type of Medium: Online Resource
    ISSN: 0364-5134 , 1531-8249
    URL: Issue
    URL: Article
    DOI: 10.1002/ana.v32:2
    DOI: 10.1002/ana.410320208
    Language: English
    Publisher: Wiley
    Publication Date: 1992
    detail.hit.zdb_id: 80362-5
    detail.hit.zdb_id: 2037912-2
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  • 2
    Online Resource
    Online Resource
    Regional spectral analysis of the REM sleep EEG in mild to moderate Alzheimer's disease
    Elsevier BV ; 1993
    In:  Neurobiology of Aging Vol. 14, No. 2 ( 1993-3), p. 141-145
    Details
    In: Neurobiology of Aging, Elsevier BV, Vol. 14, No. 2 ( 1993-3), p. 141-145
    Type of Medium: Online Resource
    ISSN: 0197-4580
    URL: Article
    DOI: 10.1016/0197-4580(93)90089-T
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1993
    detail.hit.zdb_id: 604505-4
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    THA does not affect sleep or EEG spectral power in Alzheimer's disease
    Elsevier BV ; 1993
    In:  Biological Psychiatry Vol. 33, No. 10 ( 1993-5), p. 753-754
    Details
    In: Biological Psychiatry, Elsevier BV, Vol. 33, No. 10 ( 1993-5), p. 753-754
    Type of Medium: Online Resource
    ISSN: 0006-3223
    URL: Article
    DOI: 10.1016/0006-3223(93)90128-Z
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1993
    detail.hit.zdb_id: 209434-4
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Differential impact of obstructive sleep apnea on hippocampal structure in late middle‐aged and older women and men
    Wiley ; 2021
    In:  Alzheimer's & Dementia Vol. 17, No. S6 ( 2021-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 17, No. S6 ( 2021-12)
    Abstract: Recent studies have suggested that obstructive sleep apnea (OSA) could be a modifiable risk factor for dementia. Consequently, efforts have been made to better understand the role of OSA on brain structure integrity, but results between studies are inconsistent. Discrepancies could be partly due to moderating factors (e.g., sex) or complex physiological mechanisms (e.g., oedema) that blur the association between OSA and brain structure. Here, we investigated the association between OSA severity and hippocampal grey matter volume in women and men. We also performed free‐water fraction analyses to understand how oedema could impact hippocampal volumes. Method Seventy‐three men (age: 65.47±7.22 years; apnea‐hypopnea index [AHI]: 15.52±16.14 events/h; 31 with mild cognitive impairments [MCI] ) and 47 women (age: 71.11 ± 6.65; AHI: 11.56 ± 9.92; 22 with MCI) underwent an overnight polysomnography, a neuropsychological evaluation and a magnetic resonance imaging session. Using the hippocampal subfield module in Freesurfer 7.1, total bilateral hippocampal volumes were extracted and normalised to the total intracranial volume. Diffusion data was preprocessed using TractoFlow‐ABS, and Freewater‐Flow and the Sherbrooke Connectivity Imaging Lab scripts were used to extract bilateral hippocampal free‐water fraction. Controlling for age and cognitive status, sex‐stratified linear regressions were performed between (i) the bilateral hippocampal volume or (ii) Free‐water‐corrected bilateral hippocampal volume and log‐transformed AHI. Result In women, we observed a positive association between the AHI and bilateral hippocampal volumes (r=0.414; p=0.005), where more severe OSA was associated with higher volumes. This association was not observed in men (p=0.427). When using the free‐water corrected volumes, this association was no longer significant in women (p=0.481), suggesting that the increased hippocampal volume could be due to OSA‐related cytotoxic (intracellular) oedema. Conclusion In this cohort, while men’s hippocampal volume was unaffected by OSA, women with OSA presented hippocampal hypertrophy likely due to intracellular oedema. Cytotoxic oedema is a known precursor to vasogenic (extracellular) oedema and cell death, suggesting that women might be more vulnerable to the cerebral consequences of OSA than men. Since women have a higher lifetime risk of developing Alzheimer's disease, future studies on OSA should pay a particular attention to women.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v17.S6
    DOI: 10.1002/alz.057588
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2211627-8
    detail.hit.zdb_id: 2201940-6
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  • 5
    Online Resource
    Online Resource
    Reduced rapid eye movement sleep in late middle-aged and older apolipoprotein E ɛ 4 allele carriers
    Oxford University Press (OUP) ; 2024
    In:  SLEEP Vol. 47, No. 7 ( 2024-07-11)
    Details
    In: SLEEP, Oxford University Press (OUP), Vol. 47, No. 7 ( 2024-07-11)
    Abstract: Apolipoprotein E ɛ4 (APOE4) is the strongest genetic risk factor for Alzheimer’s disease (AD). In addition, APOE4 carriers may exhibit sleep disturbances, but conflicting results have been reported, such that there is no clear consensus regarding which aspects of sleep are impacted. Our objective was to compare objective sleep architecture between APOE4 carriers and non-carriers, and to investigate the modulating impact of age, sex, cognitive status, and obstructive sleep apnea (OSA). Methods A total of 198 dementia-free participants aged & gt;55 years old (mean age: 68.7 ± 8.08 years old, 40.91% women, 41 APOE4 carriers) were recruited in this cross-sectional study. They underwent polysomnography, APOE4 genotyping, and a neuropsychological evaluation. ANCOVAs assessed the effect of APOE4 status on sleep architecture, controlling for age, sex, cognitive status, and the apnea–hypopnea index. Interaction terms were added between APOE4 status and covariates. Results Rapid eye movement (REM) sleep percentage (F = 9.95, p = .002, ηp2 = 0.049) and duration (F = 9.23, p = .003, ηp2 = 0.047) were lower in APOE4 carriers. The results were replicated in a subsample of 112 participants without moderate-to-severe OSA. There were no significant interactions between APOE4 status and age, sex, cognitive status, and OSA in the whole sample. Conclusions Our results show that APOE4 carriers exhibit lower REM sleep duration, including in cognitively unimpaired individuals, possibly resulting from early neurodegenerative processes in regions involved in REM sleep generation and maintenance.
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsae094
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2024
    detail.hit.zdb_id: 424441-2
    detail.hit.zdb_id: 2056761-3
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  • 6
    Online Resource
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    Associations between REM‐sleep EEG spectral power, the cholinergic basal forebrain volume and episodic memory in ageing
    Wiley ; 2021
    In:  Alzheimer's & Dementia Vol. 17, No. S6 ( 2021-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 17, No. S6 ( 2021-12)
    Abstract: Our research team has demonstrated that quantitative electroencephalography (qEEG) slowing during rapid‐eye movement (REM) sleep is a more powerful tool to discriminate patients with mild cognitive impairment (MCI) or Alzheimer Disease (AD) from healthy controls than waking EEG. Cortical activation during REM sleep highly depends on the cholinergic basal forebrain system (BFCS) neurons, while other neuronal systems are less active compared to wakefulness. However, the BFCS degenerates early in AD. Here, we tested the hypothesis that REM sleep EEG activity could be strongly associated with neurodegeneration of the BFCS, before the onset of dementia. Method 134 participants (mean age 68.45 ± 7.8 years; 52 women; 61 with MCI) underwent a polysomnography, structural magnetic resonance imaging, and a neuropsychological evaluation. T1‐weighted images were preprocessed using CAT12 and the DARTEL algorithm, and the JuBrain Anatomy Toolbox was used to extract bilateral BFCS volumes (i.e., Ch1‐2‐3, Ch4 and total volume). Based on prior evidence, theta (4‐8Hz) and alpha (8‐13Hz) absolute EEG power during REM sleep were computed on temporal electrodes (T3‐T4‐T5‐T6). A composite episodic memory score was calculated as the mean of Z‐scores obtained on the Rey Auditory Verbal Learning Test immediate and delayed free recalls. Multiple regressions were performed between (i) spectral power values or (ii) episodic memory performance, and basal forebrain volumes controlling for age, sex, the apnea‐hypopnea index, and the total intracranial volume. Complementary analyses were performed by stratifying the cohort by sex. Result Both Ch4 (r=0.24, p=0.006) and total BFCS (r=0.25, p=0.005) volumes were positively associated with episodic memory performance. Ch4 (r=‐0.21; p=0.025) and total BFCS (r=‐0.22; p=0.02) volumes were negatively associated with temporal theta power. Moreover, total BFCS (r=‐0.22; p=0.023) volumes were negatively associated with temporal alpha power. Sex‐stratified analyses revealed that the associations between BFCS volumes, REM‐sleep spectral power and episodic memory were significant in women, but not in men. Conclusion These results confirmed that cortical activation during REM sleep is sensitive to volume loss in the BFCS, a cholinergic region known to degenerate early in AD. Why this association was only observed in women is intriguing and will need further investigation.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v17.S6
    DOI: 10.1002/alz.057683
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2211627-8
    detail.hit.zdb_id: 2201940-6
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  • 7
    Online Resource
    Online Resource
    REM sleep is associated with the volume of the cholinergic basal forebrain in aMCI individuals
    Springer Science and Business Media LLC ; 2023
    In:  Alzheimer's Research & Therapy Vol. 15, No. 1 ( 2023-09-08)
    Details
    In: Alzheimer's Research & Therapy, Springer Science and Business Media LLC, Vol. 15, No. 1 ( 2023-09-08)
    Abstract: Rapid-eye movement (REM) sleep highly depends on the activity of cholinergic basal forebrain (BF) neurons and is reduced in Alzheimer’s disease. Here, we investigated the associations between the volume of BF nuclei and REM sleep characteristics, and the impact of cognitive status on these links, in late middle-aged and older participants. Methods Thirty-one cognitively healthy controls (66.8 ± 7.2 years old, 13 women) and 31 participants with amnestic Mild Cognitive Impairment (aMCI) (68.3 ± 8.8 years old, 7 women) were included in this cross-sectional study. All participants underwent polysomnography, a comprehensive neuropsychological assessment and Magnetic Resonance Imaging examination. REM sleep characteristics (i.e., percentage, latency and efficiency) were derived from polysomnographic recordings. T1-weighted images were preprocessed using CAT12 and the DARTEL algorithm, and we extracted the gray matter volume of BF regions of interest using a probabilistic atlas implemented in the JuBrain Anatomy Toolbox. Multiple linear regressions were performed between the volume of BF nuclei and REM sleep characteristics controlling for age, sex and total intracranial volume, in the whole cohort and in subgroups stratified by cognitive status. Results In the whole sample, lower REM sleep percentage was significantly associated to lower nucleus basalis of Meynert (Ch4) volume (β = 0.32, p  = 0.009). When stratifying the cohort according to cognitive status, lower REM sleep percentage was significantly associated to both lower Ch4 (β = 0.48, p  = 0.012) and total BF volumes (β = 0.44, p  = 0.014) in aMCI individuals, but not in cognitively unimpaired participants. No significant associations were observed between the volume of the BF and wake after sleep onset or non-REM sleep variables. Discussion These results suggest that REM sleep disturbances may be an early manifestation of the degeneration of the BF cholinergic system before the onset of dementia, especially in participants with mild memory deficits.
    Type of Medium: Online Resource
    ISSN: 1758-9193
    URL: Article
    DOI: 10.1186/s13195-023-01265-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2506521-X
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  • 8
    Online Resource
    Online Resource
    Medial temporal lobe and obstructive sleep apnea: Effect of sex, age, cognitive status and free-water
    Elsevier BV ; 2022
    In:  NeuroImage: Clinical Vol. 36 ( 2022), p. 103235-
    Details
    In: NeuroImage: Clinical, Elsevier BV, Vol. 36 ( 2022), p. 103235-
    Type of Medium: Online Resource
    ISSN: 2213-1582
    URL: Article
    DOI: 10.1016/j.nicl.2022.103235
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2701571-3
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  • 9
    Online Resource
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    REM sleep is associated with the integrity of the cholinergic basal forebrain in aMCI participants
    Wiley ; 2022
    In:  Alzheimer's & Dementia Vol. 18, No. S7 ( 2022-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 18, No. S7 ( 2022-12)
    Abstract: The basal forebrain cholinergic system (BFCS) degenerates in Alzheimer’s disease (AD) before the onset of dementia. Interestingly, rapid‐eye movement (REM) sleep is highly dependent on cholinergic activity. In AD patients, REM sleep duration is reduced but the underlying brain mechanisms are still unclear. Our objective was to investigate the associations between REM‐sleep quantity and BFCS integrity in participants with amnestic mild cognitive impairment (aMCI) compared to healthy controls. Method Sixty‐two participants (31 cognitively healthy: 66.8 ± 7.2 years old, 13 women; 31 aMCI: 68.3 ± 8.8 years old, 7 women) underwent polysomnography and structural magnetic resonance imaging examinations. REM sleep duration (number of minutes) and proportion (%) were computed. All participants had a REM sleep apnea‐hypopnea index 〈 15. T1‐weighted images were preprocessed using CAT12 and the DARTEL algorithm, and the mean intensity of BFCS subregions (i.e., Ch1‐2‐3, Ch4 and total BFCS) was extracted using the JuBrain Anatomy Toolbox. Multiple regressions were performed between BFCS subregional intensities and REM sleep indices controlling for age, sex and total intracranial volume, in the whole cohort and in the two groups separately. Result In the whole cohort, REM sleep duration and proportion were positively associated with Ch4 intensity (duration: r = 0.31, p = 0.017; proportion: r = 0.35, p = 0.007; Figure 1A and B) and total BFCS intensity (duration: r = 0.31, p = 0.016; proportion: r = 0.29, p = 0.024). Analyses stratified by cognitive status showed the same pattern in aMCI participants: REM sleep duration and proportion were positively associated with both Ch4 intensity (duration: r = 0.44, p = 0.018; proportion: r = 0.49, p = 0.009; Figure 1C and D) and total BFCS intensity (duration: r = 0.46, p = 0.014; proportion: r = 0.46, p = 0.013). No significant association, nor trend, was found in cognitively healthy participants (Figure 1C and D). Conclusion In aMCI participants, lower REM sleep duration and proportion were associated with a decreased integrity of the BFCS, especially the Nucleus Basalis of Meynert. Our results support the notion that REM sleep alterations are an early marker of the degeneration of the BFCS in prodromal AD, before the onset of dementia.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v18.S7
    DOI: 10.1002/alz.067250
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2211627-8
    detail.hit.zdb_id: 2201940-6
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  • 10
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    Subjective sleep characteristics associated with anxiety and depression in older adults: a population‐based study
    Wiley ; 2014
    In:  International Journal of Geriatric Psychiatry Vol. 29, No. 12 ( 2014-12), p. 1262-1270
    Details
    In: International Journal of Geriatric Psychiatry, Wiley, Vol. 29, No. 12 ( 2014-12), p. 1262-1270
    Abstract: Sleep complaints are often associated with anxiety and depression, but the specific complaints related to each syndrome are poorly characterized, especially in older adults. The objective was to identify subjective sleep characteristics specific to anxiety and depression in this population. Methods A random sample of 2393 individuals aged 65 years or older was used. Anxiety and depression were categorized using DSM‐V criteria for phobias, panic disorder, generalized anxiety disorder, unspecified anxiety disorder, major depressive episode, and depressive episode with insufficient symptoms. Subjective sleep characteristics were measured using the Pittsburgh Sleep Quality Index. Logistic regression models predicting anxiety or depression were used to determine the independent sleep characteristics associated with each syndrome adjusting for age, sex, education level, cognitive functioning, anxiolytic/sedative/hypnotic use, antidepressants use, subjective health, chronic diseases, cardiovascular conditions, and anxiety or depression (as appropriate). Results Nearly all Pittsburgh Sleep Quality Index subscales were significantly associated with anxiety, but these subscales shared variance and only sleep duration in hours, sleep disturbance score, and daytime functioning score were independently related to anxiety. Within these significant subscales, the main specific sleep complaints associated with anxiety were daytime sleepiness and sleep disturbances related to coughing/snoring, feeling cold, and bad dreams. The use of sleeping medication was the only specific sleep characteristic associated with depression. Conclusions These results suggest that in older adults, symptoms of short sleep duration, daytime sleepiness and sleep disturbances are independently related to anxiety while the use of sleep medication is independently associated to depression. Copyright © 2014 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0885-6230 , 1099-1166
    URL: Issue
    URL: Article
    DOI: 10.1002/gps.v29.12
    DOI: 10.1002/gps.4106
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 806736-3
    detail.hit.zdb_id: 1500455-7
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