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  • 1
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 38, No. 15_suppl ( 2020-05-20), p. 4108-4108
    Abstract: 4108 Background: Circulating tumor DNA (ctDNA) testing can be used for the assessment of molecular residual disease (MRD) in patients with early-stage or advanced colorectal cancer (CRC). Prospective evaluation of this methodology in clinical practice has been limited to-date. Methods: A personalized and tumor-informed multiplex PCR assay (Signatera 16-plex bespoke mPCR NGS assay) was used for the detection and quantification of ctDNA for MRD assessment. We analyze and present results from an ongoing early adopter program of ctDNA testing across the spectrum of CRC management. Results: Here we present a total of 250 patients with colon (n=200), rectal (n=40), and other lower gastrointestinal cancers (n =10; anal, appendiceal, small bowel). MRD positivity rates and ctDNA quantification (mean tumor molecules/mL) are shown in Table. ctDNA detection was significantly associated with stage of disease (p 〈 0.0001 Chi-square: 70.33). Additionally, in patients with radiologically measurable active metastatic disease, ctDNA detection rate was 100%. On the contrary, patients with advanced/metastatic disease who had partial response to treatment or no evidence of disease (NED) showed 28.5% and 19.2% of ctDNA-positivity, respectively. Conclusions: This is the first large, real-world study reporting on the results from a clinically validated MRD assay. For the first time we delineate MRD rates and quantify ctDNA concentration in patients with early-stage and advanced CRC. Furthermore, we provide an initial readout that effective ongoing treatment in patients with CRC may be correlated with ctDNA clearance. Ongoing analysis expanded to a cohort of 1200 clinical cases including correlation with genomic and serial testing will be presented. [Table: see text]
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
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    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2020
    detail.hit.zdb_id: 2005181-5
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  • 2
    Online Resource
    Online Resource
    The Oceanography Society ; 2021
    In:  Oceanography Vol. 34, No. 2 ( 2021-06-01)
    In: Oceanography, The Oceanography Society, Vol. 34, No. 2 ( 2021-06-01)
    Abstract: Since HMS Challenger made the first sounding in the Mariana Trench in 1875, scientists and explorers have been seeking to establish the exact location and depth of the deepest part of the ocean. The scientific consensus is that the deepest depth is situated in the Challenger Deep, an abyss in the Mariana Trench with depths greater than 10,000 m. Since1952, when HMS Challenger II, following its namesake, returned to the Mariana Trench, 20 estimates (including the one from this study) of the depth of the Challenger Deep have been made. The location and depth estimates are as diverse as the methods used to obtain them; they range from early measurements with explosives and stop watches, to single- and multi-beam sonars, to submersibles, both crewed and remotely operated. In December 2014, we participated in an expedition to the Challenger Deep onboard Schmidt Ocean Institute’s R/V Falkor and deployed two free-falling, passive-acoustic instrument platforms, each with a glass-sphere pressure housing containing system electronics. At a nominal depth of 9,000 m, one of these housings imploded, creating a highly energetic shock wave that, as recorded by the other instrument, reflected multiple times from the sea surface and seafloor. From the arrival times of these multi-path pulses at the surviving instrument, in conjunction with a concurrent measurement of the sound speed profile in the water column, we obtained a highly constrained acoustic estimate of the Challenger Deep: 10,983 ± 6 m.
    Type of Medium: Online Resource
    ISSN: 1042-8275
    Language: Unknown
    Publisher: The Oceanography Society
    Publication Date: 2021
    detail.hit.zdb_id: 1167549-4
    detail.hit.zdb_id: 2268693-9
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  • 3
    Online Resource
    Online Resource
    American Geophysical Union (AGU) ; 2020
    In:  Journal of Geophysical Research: Oceans Vol. 125, No. 10 ( 2020-10)
    In: Journal of Geophysical Research: Oceans, American Geophysical Union (AGU), Vol. 125, No. 10 ( 2020-10)
    Abstract: A shipboard broadband acoustic survey was performed at the site of a seafloor‐sourced oil spill to determine the flow rate of hydrocarbons The rise rate and amplitude and shape of broadband backscatter determined the size, number, and identity (oil or gas) of targets The flow rate of liquid hydrocarbons was estimated to be between 56 and 86 barrels per day
    Type of Medium: Online Resource
    ISSN: 2169-9275 , 2169-9291
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2020
    detail.hit.zdb_id: 2016804-4
    detail.hit.zdb_id: 161667-5
    detail.hit.zdb_id: 3094219-6
    SSG: 16,13
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  • 4
    Online Resource
    Online Resource
    Acoustical Society of America (ASA) ; 2016
    In:  Journal of the Acoustical Society of America Vol. 139, No. 4_Supplement ( 2016-04-01), p. 2174-2174
    In: Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 139, No. 4_Supplement ( 2016-04-01), p. 2174-2174
    Abstract: Development of instrumentation to detect and quantify submerged oil droplets would provide researchers and oil spill responders with crucial information about the fate and movement of oil in the environment. By detecting oil droplets in the watercolumn it should be possible to trace surface sheens to their source and to determine the location and extent of plumes of oil at depth. Methods of detecting oil currently exist, for example, mass spectrometers and fluorometers; however, they are limited to detecting oil that is submeter range from the instrument. Using broadband high frequency (30–300 kHz) acoustic echosounders, it is possible to not only detect oil droplets from a greater distance (10s of meters for individual droplets, depending on the background noise) but to quantify the physical properties of the oil, including the size of droplets. Droplet size is an important factor in determining the likely location of submerged plumes and surface sheens, the rate of biodegradation and rise rate of oil. Laboratory measurements of the broadband response along with the sound speed, density and droplet size of crude oil, diesel, gasoline, and kerosene have been made. The frequency response of the droplets have been compared to models for the target strength of fluid filled spheres to verify the models, and to empirically derive adjustments if necessary. The data are also used to empirically estimate a detection range limit for different densities of droplets determined.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
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    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2016
    detail.hit.zdb_id: 1461063-2
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  • 5
    Online Resource
    Online Resource
    Acoustical Society of America (ASA) ; 2017
    In:  The Journal of the Acoustical Society of America Vol. 142, No. 4_Supplement ( 2017-10-01), p. 2506-2506
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 142, No. 4_Supplement ( 2017-10-01), p. 2506-2506
    Abstract: The detection and quantification of crude oil in ocean environments is dependent on adequately constrained acoustic properties (e.g., density and sound speed). However, there is a paucity of published acoustic property measurements of crude oil at oceanographically relevant temperatures and pressures. Three medium crude oil samples (Alaska North Slope, Angola Bavuca, and Angola Xikomba) were tested to better constrain these properties for oceanographic applications. A temperature (−10 to 30 °C) and pressure (0.1 to 19.3 MPa) controlled sound speed chamber was developed for highly accurate differential time of flight measurements. Density and viscosity were also measured over the same temperature range. Finally, differential scanning calorimetry measurements (−40 to 50 °C) were conducted to identify phase changes in crude oil constituents that may contribute to nonlinearities in acoustic properties as a function of temperature at a constant pressure. Results are compared to previously available models for sound speed, such as the PC-Shaft model, and density as a function of temperature and pressure. The results can also be used to fully constrain models of the shape of oil droplets in the marine environment as a function of size, an important input for models of acoustic scattering.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
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    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2017
    detail.hit.zdb_id: 1461063-2
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  • 6
    Online Resource
    Online Resource
    Acoustical Society of America (ASA) ; 2017
    In:  The Journal of the Acoustical Society of America Vol. 142, No. 4_Supplement ( 2017-10-01), p. 2505-2505
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 142, No. 4_Supplement ( 2017-10-01), p. 2505-2505
    Abstract: Free methane gas is increasingly observed escaping the seabed in the world’s oceans from sources that are either biogenic, typically in shallow sediments, or from deeper geologic reservoirs. Methane gas bubbles undergo a complicated journey as they rise toward the sea surface. Some or all of the methane may pass through the gas-liquid boundary, into aqueous solution, where it is eventually oxidized and can impact ocean chemistry. Some of the methane, particularly in shallow environments, may reach the atmosphere where it acts as a strong greenhouse gas. One of the key questions regarding the transport of methane upward from the seabed is how much goes where, and this question is being increasingly addressed using acoustic remote sensing techniques. Answering this question begins with seep detection and localization, now routinely performed on data collected with split-beam and multibeam echo sounders. Once located, observations of the bubble-plume backscattering cross section can be used to address questions of flux and vertical gas transport. Both narrow- and broad-band techniques and some of the associated challenges, including wobbly bubbles and multiple scattering in dense plumes, will be discussed.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    RVK:
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2017
    detail.hit.zdb_id: 1461063-2
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  • 7
    Online Resource
    Online Resource
    Acoustical Society of America (ASA) ; 2019
    In:  The Journal of the Acoustical Society of America Vol. 145, No. 3_Supplement ( 2019-03-01), p. 1653-1653
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 145, No. 3_Supplement ( 2019-03-01), p. 1653-1653
    Abstract: Recent technological advances in high-frequency ( & gt;10 kHz) sonar transducers, sonar transceivers, and sonar design have been accompanied by increased capabilities for observing ocean phenomena. These advances include the high range resolution and frequency-domain target classification capabilities associated with wideband acoustic echo sounders, the long-range high-resolution synoptic imaging capabilities associated with multibeam echo sounders and synthetic aperture sonar, and an increased focus on sensor calibration for all systems. High-frequency sonars are increasingly being used to quantify ocean phenomena at scales ranging from sub-centimeter (e.g., individual gas bubbles) to 100s of km (e.g., internal waves) to several 10s of km (e.g., thermohaline staircases). In this talk, we highlight some of the ocean processes that we have been investigating using high-frequency sonar systems, typically involving the transport of hydrocarbons, heat, energy, and fresh water into and through the ocean, and some of the (many) acoustic challenges that must be overcome to continue to increase the value of these observations.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    RVK:
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2019
    detail.hit.zdb_id: 1461063-2
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  • 8
    Online Resource
    Online Resource
    Acoustical Society of America (ASA) ; 2019
    In:  The Journal of the Acoustical Society of America Vol. 146, No. 2 ( 2019-08-01), p. 1176-1188
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 146, No. 2 ( 2019-08-01), p. 1176-1188
    Abstract: Improved in situ quantification of oil in the marine environment is critical for informing models of fate and transport and evaluating the resiliency of marine communities to oil spills. Broadband acoustic backscatter has been used to quantify a variety of targets in the water column; from fish and planktonic organisms to gas bubbles and oceanic microstructure, and shows promise for use in quantifying oil droplets. Quantifying water column targets with broadband acoustic backscatter relies on accurate models of a target's frequency dependent target strength (TS), a function of the target's acoustic impedance, shape, and size. Previous acoustic quantification of oil droplets has assumed that droplets were spheres. In this study, broadband (100.5–422 kHz) acoustic backscatter from individual oil droplets was measured, and the frequency dependent TS compared to a model of acoustic scattering from fluid spheres and two models for more complex shapes. Droplets of three different crude oils, two medium oils, and one heavy oil were quantified and all droplets were oblate spheroids. The impact of the deviation from sphericity on the accuracy of each model was determined. If an inversion of the model for spherical droplets was used to estimate flux from acoustic observations, errors in the predicted volume of a droplet were between 30% and 50%. The heavy oil also showed deviations in predicted volume of 20%–40% when using the two models for more complex shapes.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    RVK:
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2019
    detail.hit.zdb_id: 1461063-2
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  • 9
    Online Resource
    Online Resource
    Acoustical Society of America (ASA) ; 2022
    In:  The Journal of the Acoustical Society of America Vol. 151, No. 4_Supplement ( 2022-04-01), p. A148-A149
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 151, No. 4_Supplement ( 2022-04-01), p. A148-A149
    Abstract: Any oceanic environment with spatial gradients in sound speed and density can result in acoustic scattering hot spots. These acoustic hotspots can be rapidly evolving and vary in their spatial heterogeneity. Here, we present data collected with a variety of split-beam and multi-beam echosounders illustrating the broad array of environments and spatial scales associated with scattering from physical microstructure, including shear instabilities in estuarine environments, non-linear internal waves on the continental shelf, strong interface scattering due to double-diffusion, scattering from strong gradients, or interfaces, and turbulent microstructure at the new England Shelf Break Front. The theoretical acoustic scattering formulations for different types of physical microstructure are applied to these different environments, and recommendations are made for optimal frequency bands to sample the different types of physical microstructure and the optimal measurements for inference of parameters that describe the physical microstructure. The impact of other scattering sources, such as suspended sediments, bubbles, and biological targets, on successful acoustic sampling of physical microstructure is also discussed. [This work was supported by the ONR.]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    RVK:
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2022
    detail.hit.zdb_id: 1461063-2
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  • 10
    Online Resource
    Online Resource
    Acoustical Society of America (ASA) ; 2022
    In:  The Journal of the Acoustical Society of America Vol. 152, No. 4_Supplement ( 2022-10-01), p. A152-A152
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 152, No. 4_Supplement ( 2022-10-01), p. A152-A152
    Abstract: Any oceanic environment with spatial gradients in sound speed and density can result in acoustic scattering hot spots. These acoustic hotspots can be rapidly evolving and vary in their spatial heterogeneity. Here, we review acoustic scattering models for turbulence and present data collected with a variety of split-beam and multi-beam echosounders illustrating the range of environments and spatial scales associated with scattering from physical microstructure, including shear instabilities in estuarine environments, non-linear internal waves on the continental shelf, strong interface scattering due to double-diffusion, scattering from strong gradients or interfaces, and turbulent microstructure at the New England shelf break front. The theoretical acoustic scattering formulations for different types of physical microstructure are applied to these different environments, and recommendations are made for optimal frequency bands to sample the different types of physical microstructure and the optimal measurements for inference of parameters that describe the physical microstructure. Limitations imposed on detection and quantification of scattering from the physical microstructure due to sources including suspended sediment, bubbles, and biological targets, are also discussed. [Work supported by the ONR.]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    RVK:
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2022
    detail.hit.zdb_id: 1461063-2
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