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  • 1
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    Online Resource
    Impact and attitudes toward genetic counseling and testing in individuals at high risk for familial Alzheimer’s Disease.
    Wiley ; 2022
    In:  Alzheimer's & Dementia Vol. 18, No. S11 ( 2022-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 18, No. S11 ( 2022-12)
    Abstract: Pre‐symptomatic genetic testing for individuals with dominantly inherited Alzheimer’s disease (DIAD) is now attracting interest due to the existence of therapeutic trials available to this population. Although the impact and the main drivers influencing the decision to seek genetic testing have been widely studied in High‐Income Countries, these reasons remain relatively unknown in Latin America (LatAm). Methods This study was designed to explore attitudes toward genetic testing and the impact of finding a disease‐causing mutation for early‐onset Alzheimer’s disease. The genetic counseling sessions, included a culturally sensitive program, developed in collaboration with local experts. Asymptomatic, first‐degree relatives of patients with Alzheimer’s disease dementia from an extended Colombian family (∼300) with a presenilin 1 pathogenic variant (p. I416T) were interviewed before and after genetic testing. Pre and post genetic counseling and testing measurements included the Montgomery Depression Scale, the Zung Anxiety Rating, and Genetic Counseling Outcome Scale. Primary analyses examined change in anxiety and depression scores 3 months after disclosure using linear mixed effects models and chi‐squared tests. Secondary outcomes included short Health Anxiety Inventory and knowledge about Alzheimer disease. Results Twenty‐five participants were invited and enrolled in the study (Figure 1). Nineteen individuals completed the genetic counseling sessions and 8/18 (44.4%) learned their genetic status. Three months after genetic status disclosure, we found no significant differences between the group that learned their genetic status and those how did not learn their genetic status in anxiety (mean = 13.5, SD = 3.2 vs. 15.1, SD = 2.5, p = 0.2) or depression (mean = 5.4, SD = 2.3 vs mean = 8.0, SD = 6.5, p = 0.6) scores. For both groups, anxiety and depression scores remained below cutoffs for clinical concern and without significant changes relative to baseline values levels. Conclusion Our pilot study shows that a structured genetic counseling and testing protocol for individuals at‐risk of DIAD is safe and and may provide psychological benefits. Future studies should include larger cohorts and expand to other countries in LatAm.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v18.S11
    DOI: 10.1002/alz.064021
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2201940-6
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  • 2
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    Evaluación comparativa de parámetros productivos en diferentes cruces de ganado Blanco-Orejinegro con Holstein
    Corporacion Colombiana de Investigacion Agropecuaria (Corpoica) ; 2017
    In:  Ciencia & Tecnología 〈/br〉Agropecuaria Vol. 18, No. 3 ( 2017-08-31), p. 513-527
    Details
    In: Ciencia & Tecnología 〈/br〉Agropecuaria, Corporacion Colombiana de Investigacion Agropecuaria (Corpoica), Vol. 18, No. 3 ( 2017-08-31), p. 513-527
    Abstract: En los sistemas de producción de leche de trópico alto en el departamento de Antioquia (Colombia), la utilización de la raza Holstein ha permitido obtener altos niveles de producción. No obstante, la implementación de cruces con razas criollas es una opción para introducir genes que aporten adaptabilidad al medio. El objetivo de este trabajo es comparar parámetros productivos entre ganado Holstein y sus cruces con Blanco-Orejinegro, en diferentes proporciones de ambas razas. Se utilizaron 125 lactancias pertenecientes a 48 vacas de un hato antioqueño. Se ajustaron modelos mixtos de medidas repetidas, incluyendo efectos fijos de número de parto, grupo genético y grupo contemporáneo. Se usaron modelos de regresión lineal para evaluar el efecto del porcentaje de la raza criolla sobre los parámetros productivos. El grupo genético tuvo un efecto significativo sobre la producción al pico, la producción total y la producción para el día 150. El Holstein puro presentó un mayor desempeño que los animales cruzados para la producción de leche (x=6.853,48 L), la producción al pico (x=34,6 L) y la producción al día 150 (x=19,97 L). El análisis de regresión lineal mostró una tendencia leve a la disminución de productividad a medida que aumenta la proporción de Blanco-Orejinegro. Si bien utilizar animales cruzados en sistemas de lechería especializada podría disminuir los parámetros productivos del hato, también permite la introducción de genes que aporten adaptación al medioambiente y resistencia a enfermedades.
    Type of Medium: Online Resource
    ISSN: 2500-5308 , 0122-8706
    URL: Issue
    URL: Article
    DOI: 10.21930/rcta.vol18-num3
    DOI: 10.21930/rcta.vol18_num3_art:741
    Language: Unknown
    Publisher: Corporacion Colombiana de Investigacion Agropecuaria (Corpoica)
    Publication Date: 2017
    detail.hit.zdb_id: 2260942-8
    SSG: 7,36
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  • 3
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    Eficiencia financiera y desempeño exportador: una aproximación empírica
    Universidad de Medellin ; 2021
    In:  Semestre Económico Vol. 24, No. 56 ( 2021-07-12), p. 77-103
    Details
    In: Semestre Económico, Universidad de Medellin, Vol. 24, No. 56 ( 2021-07-12), p. 77-103
    Abstract: Considerando el crecimiento de los negocios internacionales a raíz de los procesos de globalización de las economías, este estudio tiene como objetivo evaluar la relación entre las exportaciones y la eficiencia financiera de un conjunto de empresas colombianas durante el periodo comprendido entre 2007 y 2015. Para ello, se emplearon modelos lineales mixtos y modelos estocásticos de fronteras eficientes para identificar la importancia del activo corriente, la rentabilidad neta del activo y la duración de las empresas. De esta manera, los resultados mostraron un aporte positivo del activo corriente frente al desempeño exportador, mientras que la rentabilidad neta del activo y la duración de las empresas obtuvieron un comportamiento negativo respecto a este. El hecho de que la importancia del activo corriente guarde una relación positiva con el desempeño exportador, indica que a medida que aumenta el valor exportado, aumenta el activo corriente, probablemente a través de las cuentas de inventario y cuentas por cobrar. Asimismo, que la rentabilidad sobre los activos tenga una relación negativa muestra que es posible que las empresas estén incurriendo en altos costos de exportación que hacen disminuir sus utilidades y consecuentemente su rentabilidad.
    Type of Medium: Online Resource
    ISSN: 2248-4345 , 0120-6346
    URL: Article
    DOI: 10.22395/seec.v24n56a3
    Language: Unknown
    Publisher: Universidad de Medellin
    Publication Date: 2021
    detail.hit.zdb_id: 2532261-8
    SSG: 7,36
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  • 4
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    Effect of IGF-1 and LEP/ob SNPs on growth parameters of Blanco Orejinegro cattle
    Universidad del Zulia ; 2022
    In:  Revista de la Facultad de Agronomía, Universidad del Zulia Vol. 39, No. 2 ( 2022-6-21), p. e223933-
    Details
    In: Revista de la Facultad de Agronomía, Universidad del Zulia, Universidad del Zulia, Vol. 39, No. 2 ( 2022-6-21), p. e223933-
    Abstract: The aim of this work was to identify the effect of some SNPs of the IGF-1 and LEP/ob genes, on the growth in animals of the Blanco Orejinegro creole breed (BON) and to evaluate the relationship of age at first calving (AFC) with the curve trajectory. For this, 1217 phenotypic and 439 genomic records of pure BON bovines were used. The Gompertz, Logistic, Von Bertalanffy and Brody models were evaluated. The individual growth curve parameters were estimated and the effect of SNPs of the IGF-1 and LEP/ob genes on the curve parameters was estimated through a linear model. Finally, the association of the curve parameters and the AFC was analyzed trough a linear model. The model that represented the best fit to the growth trajectory was Brody's. On average, the BON animals presented an adult weight (β0) of 479.9±7.4 kg and a growth rate expressing the daily weight gain as a proportion of the total weight (β2) of 0.002±0.00004. The SNPs rs110654613 (nucleotide change A/G) and rs110959643 (A/G), within the IGF-1 gene, showed a significant effect (p 〈 0.05) on the parameters of the BON cattle growth curve. There were no associations of LEP/ob gene SNPs on the parameters of the BON cattle growth curve. AFC was significantly associated (p 〈 0.05) with the parameters β0 and β2. It is concluded that the use of genomic information for the IGF-1 gene can lead to higher growth rates and earlier.
    Type of Medium: Online Resource
    ISSN: 2477-9407
    Uniform Title: Efecto de SNPs de IGF-1 y LEP/ob sobre parámetros de crecimiento del ganado Blanco Orejinegro
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.47280/RevFacAgron(LUZ).v39.n2
    DOI: 10.47280/RevFacAgron(LUZ)
    DOI: 10.47280/RevFacAgron(LUZ).v39.n2.11
    Language: English
    Publisher: Universidad del Zulia
    Publication Date: 2022
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  • 5
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    Effect of minor allele frequency and density of single nucleotide polymorphism marker arrays on imputation performance and prediction ability using the single-step genomic Best Linear Unbiased Prediction in a simulated beef cattle population
    CSIRO Publishing ; 2023
    In:  Animal Production Science Vol. 63, No. 9 ( 2023-4-4), p. 844-852
    Details
    In: Animal Production Science, CSIRO Publishing, Vol. 63, No. 9 ( 2023-4-4), p. 844-852
    Abstract: Context In beef cattle populations, there is little evidence regarding the minimum number of genetic markers needed to obtain reliable genomic prediction and imputed genotypes. Aims This study aimed to evaluate the impact of single nucleotide polymorphism (SNP) marker density and minor allele frequency (MAF), on genomic predictions and imputation performance for high and low heritability traits using the single-step genomic Best Linear Unbiased Prediction methodology (ssGBLUP) in a simulated beef cattle population. Methods The simulated genomic and phenotypic data were obtained through QMsim software. 735 293 SNPs markers and 7000 quantitative trait loci (QTL) were randomly simulated. The mutation rate (10−5), QTL effects distribution (gamma distribution with shape parameter = 0.4) and minor allele frequency (MAF ≥ 0.02) of markers were used for quality control. A total of 335k SNPs (high density, HD) and 1000 QTLs were finally considered. Densities of 33 500 (35k), 16 750 (16k), 4186 (4k) and 2093 (2k) SNPs were customised through windows of 10, 20, 80 and 160 SNPs by chromosome, respectively. Three marker selection criteria were used within windows: (1) informative markers with MAF values close to 0.5 (HI); (2) less informative markers with the lowest MAF values (LI); (3) markers evenly distributed (ED). We evaluated the prediction of the high-density array and of 12 scenarios of customised SNP arrays, further the imputation performance of them. The genomic predictions and imputed genotypes were obtained with Blupf90 and FImpute software, respectively, and statistics parameters were applied to evaluate the accuracy of genotypes imputed. The Pearson’s correlation, the coefficient of regression, and the difference between genomic predictions and true breeding values were used to evaluate the prediction ability (PA), inflation (b), and bias (d), respectively. Key results Densities above 16k SNPs using HI and ED criteria displayed lower b, higher PA and higher imputation accuracy. Consequently, similar values of PA, b and d were observed with the use of imputed genotypes. The LI criterion with densities higher than 35k SNPs, showed higher PA and similar predictions using imputed genotypes, however lower b and quality of imputed genotypes were observed. Conclusion The results obtained showed that at least 5% of HI or ED SNPs available in the HD array are necessary to obtain reliable genomic predictions and imputed genotypes. Implications The development of low-density customised arrays based on criteria of MAF and even distribution of SNPs, might be a cost-effective and feasible approach to implement genomic selection in beef cattle.
    Type of Medium: Online Resource
    ISSN: 1836-0939 , 1836-5787
    URL: Article
    DOI: 10.1071/AN21581
    Language: English
    Publisher: CSIRO Publishing
    Publication Date: 2023
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  • 6
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    Exploring New Mechanisms for Effective Antimicrobial Materials: Electric Contact-Killing Based on Multiple Schottky Barriers
    American Chemical Society (ACS) ; 2017
    In:  ACS Applied Materials & Interfaces Vol. 9, No. 31 ( 2017-08-09), p. 26219-26225
    Details
    In: ACS Applied Materials & Interfaces, American Chemical Society (ACS), Vol. 9, No. 31 ( 2017-08-09), p. 26219-26225
    Type of Medium: Online Resource
    ISSN: 1944-8244 , 1944-8252
    URL: Article
    URL: Article
    DOI: 10.1021/acsami.7b09695
    DOI: 10.1021/acsami.7b09695.s001
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2017
    detail.hit.zdb_id: 2467494-1
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  • 7
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    Método estadístico de clasificación de formas de cuerpos, aplicable en el desarrollo técnico de vestuario
    Malaga University ; 2022
    In:  i+Diseño. Revista Científico-Académica Internacional de Innovación, Investigación y Desarrollo en Diseño Vol. 17 ( 2022-12-25), p. 149-162
    Details
    In: i+Diseño. Revista Científico-Académica Internacional de Innovación, Investigación y Desarrollo en Diseño, Malaga University, Vol. 17 ( 2022-12-25), p. 149-162
    Abstract: El conocimiento del cuerpo humano es uno de los grandes retos en el diseño de vestuario, la calidad en el   desarrollo técnico de una prenda surge a partir del entendimiento de las formas, medidas, tallas y proporciones que son la base para elaborar el patrón o molde en una prenda. Los métodos estadísticos y la tecnología 3D son una herramienta de gran utilidad para la industria del vestuario, facilitan la captura y análisis de datos a partir de avatares tridimensionales asociados a las diferentes tipologías de cuerpo. El método utilizado tiene como objetivo la clasificación e identificación de las formas  y tipologías del cuerpo, desarrollado en  las  siguientes etapas:   definición de los valores de referencia a partir de  medias poblacionales, definición de los anchos de intervalo  comparando las  tallas y medidas, cálculo de las diferencias en los valores de referencia,   definición del indicador relativo al tamaño de la persona, obtención de las diferencias entre las medidas, y por último la clasificación del cuerpo, lo que generó como resultados siete tipologías de cuerpos clasificados según sus formas.
    Type of Medium: Online Resource
    ISSN: 1889-433X
    URL: Issue
    URL: Article
    DOI: 10.24310/Idiseno.2022.v17i
    DOI: 10.24310/Idiseno.2022.v17i.14735
    Language: Unknown
    Publisher: Malaga University
    Publication Date: 2022
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  • 8
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    Identidad profesional docente en tiempos de crisis: relevancia de la empatía en la práctica pedagógica
    Red Iberoamericana de Pedagogia ; 2021
    In:  Revista Boletín Redipe Vol. 10, No. 12 ( 2021-12-01), p. 350-359
    Details
    In: Revista Boletín Redipe, Red Iberoamericana de Pedagogia, Vol. 10, No. 12 ( 2021-12-01), p. 350-359
    Abstract: En el artículo se analiza, desde las narrativas de profesores y estudiantes, las transformaciones que se han dado en la identidad docente en el contexto de la pandemia y cómo estas se constituyen en fundamento para la agenda de formación de maestros en la década que vivimos. Se realiza desde una perspectiva cualitativa con método de documentación   narrativa, para conocer las vivencias de los docentes y estudiantes desde su propia voz y reconstruir los saberes, actitudes, en definitiva, la experiencia que tienen los docentes de su propio trabajo en el marco de esta crisis sanitaria mundial. El análisis permite inferir que la empatía se reconoce como una actitud profesional que ha tenido poder transformador en los sentimientos y acciones de los estudiantes, y que permitió acompañar y continuar con los procesos de enseñanza y de aprendizaje.
    Type of Medium: Online Resource
    ISSN: 2256-1536
    URL: Article
    DOI: 10.36260/rbr.v10i12.1594
    Language: Unknown
    Publisher: Red Iberoamericana de Pedagogia
    Publication Date: 2021
    detail.hit.zdb_id: 3001699-X
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  • 9
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    Accuracy of genomic breeding values and predictive ability for postweaning liveweight and age at first calving in a Nellore cattle population with missing sire information
    Springer Science and Business Media LLC ; 2021
    In:  Tropical Animal Health and Production Vol. 53, No. 4 ( 2021-09)
    Details
    In: Tropical Animal Health and Production, Springer Science and Business Media LLC, Vol. 53, No. 4 ( 2021-09)
    Type of Medium: Online Resource
    ISSN: 0049-4747 , 1573-7438
    URL: Article
    DOI: 10.1007/s11250-021-02879-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2005233-9
    SSG: 22
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  • 10
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    Estimates of genetic and phenotypic parameters for feeding behaviour and feed efficiency‐related traits in Nelore cattle
    Wiley ; 2023
    In:  Journal of Animal Breeding and Genetics Vol. 140, No. 3 ( 2023-05), p. 264-275
    Details
    In: Journal of Animal Breeding and Genetics, Wiley, Vol. 140, No. 3 ( 2023-05), p. 264-275
    Abstract: The objective of this study was to obtain (co)variance components, heritability, and genetic and phenotypic correlation estimates for feed efficiency and feed behaviour‐related indicator traits. Further, it aimed to predict the direct and correlated responses for feed efficiency traits when selection was applied for feeding behaviour‐related traits in Nelore cattle. Phenotypic records ( n = 4840 ) from 125 feed efficiency tests (RFI: Residual feed intake and DMI: Dry matter intake) carried out between 2011 and 2018 were considered in this study. Animals belonged to five farms located in two Brazilian geographical regions (Midwest and Southeast). Animals under similar management and environmental conditions in the feedlot were evaluated when they attained an average of 13.5 ± 4.15 months of age. Feed behaviour‐related traits were also obtained, including meal criteria (MC), meal frequency (MF), average meal duration (AMD), meal duration (MD), average consumption per meal (ACM), and consumption rate (CR) through the GrowSafe System® electronic bunk system. The contemporary groups for all traits were composed of farm, management group, feed efficiency test, sex, and birth year. The (co)variance components were estimated using the restricted maximum likelihood method considering a multi‐trait ( n = 8 ) animal model. The heritability estimates for RFI (0.23 ± 0.02), DMI (0.31 ± 0.02), MF (0.65 ± 0.02), AMD (0.29 ± 0.02), ACM (0.24 ± 0.02), MD (0.41 ± 0.02), MC (0.48 ± 0.02), and CR (0.42 ± 0.02) were moderate to high. The highest genetic correlation was obtained between CR and MD (−0.91 ± 0.04), MD and AMD (0.73 ± 0.03), CR and AMD (−0.68 ± 0.04), and RFI and DMI (0.81 ± 0.02). The highest phenotypic correlation was between ACM and AMD (0.76 ± 0.02), DMI and MD (0.77 ± 0.02), and DMI and RFI (0.77 ± 0.02). Genetic improvement for feed efficiency and feeding behaviour‐related traits is feasible and the results obtained herein provided valuable information regarding the genetic background of Nelore feeding behaviour‐related traits. The genetic association between feeding behaviour and feed efficiency‐related traits suggested that animals spending less time feeding at a low feeding rate also had lower DMI and higher feed efficiency (RFI), and likely had lower energy maintenance requirements. The relative efficiency of selection showed that feeding behaviour‐related traits were not adequate indicator traits to improve RFI and DMI. The DMI might be an effective selection criterion to improve RFI and reduce the herd's maintenance requirements.
    Type of Medium: Online Resource
    ISSN: 0931-2668 , 1439-0388
    URL: Issue
    URL: Article
    DOI: 10.1111/jbg.v140.3
    DOI: 10.1111/jbg.12756
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2020402-4
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