In:
ILAR Journal, Oxford University Press (OUP), Vol. 62, No. 1-2 ( 2021-12-31), p. 133-168
Abstract:
Animal models provide a valuable tool and resource for biomedical researchers as they investigate biological processes, disease pathogenesis, novel therapies, and toxicologic studies. Interpretation of animal model data requires knowledge not only of the processes/diseases being studied but also awareness of spontaneous conditions and background lesions in the model that can influence or even confound the study results. Species, breed/stock, sex, age, anatomy, physiology, diseases (noninfectious and infectious), and neoplastic processes are model features that can impact the results as well as study interpretation. Here, we review these features in several common laboratory animal species, including ferret, dog (beagle), pig, sheep, and goats.
Type of Medium:
Online Resource
ISSN:
1084-2020
,
1930-6180
DOI:
10.1093/ilar/ilab005
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2021
detail.hit.zdb_id:
2192062-X
detail.hit.zdb_id:
2710925-2
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