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  • 1
    Online Resource
    Online Resource
    Secondary infection in severe and critical COVID-19 patients in China: a multicenter retrospective study
    AME Publishing Company ; 2021
    In:  Annals of Palliative Medicine Vol. 10, No. 8 ( 2021-8), p. 8557-8570
    Details
    In: Annals of Palliative Medicine, AME Publishing Company, Vol. 10, No. 8 ( 2021-8), p. 8557-8570
    Type of Medium: Online Resource
    ISSN: 2224-5820 , 2224-5839
    URL: Journal
    URL: Article
    DOI: 10.21037/apm
    DOI: 10.21037/apm-21-833
    Language: Unknown
    Publisher: AME Publishing Company
    Publication Date: 2021
    detail.hit.zdb_id: 2828544-X
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  • 2
    Online Resource
    Online Resource
    Preparation and Characterization of Magenetically Core-Shell Structure Carbon Based Solid Sulfonic Acid
    Trans Tech Publications, Ltd. ; 2012
    In:  Advanced Materials Research Vol. 599 ( 2012-11), p. 86-90
    Details
    In: Advanced Materials Research, Trans Tech Publications, Ltd., Vol. 599 ( 2012-11), p. 86-90
    Abstract: Magnetically core-shell structure carbon based solid sulfonic acid were prepared and characterized systematically. In a typical procedure, Fe3O4 particles were prepared by following the literature report. The Fe3O4 was then modified by oleic acid under the sonication. A coal pitch layer was produced and polymerization on the surface of nano-Fe3O4 at 573 K for 6 h under O2 atmosphere and followed by carbonization at 773 K in flowing nitrogen. SO3H bearing multifunctional composites were finally prepared with sulfonation process in fuming sulfuric acid.The structure, morphology and ferromagnetic property of ferrite powders and composites were characterized by XPS, TEM, FTIR spectra, and VSM respectively. The advantages, including high acidic concentration and magnetically active, are potentially important for industrial applications of the Core-shell Structure Carbon Based Solid Sulfonic Acid as an efficient heterogeneous solid acid catalyst in the future.
    Type of Medium: Online Resource
    ISSN: 1662-8985
    URL: Issue
    URL: Article
    DOI: 10.4028/www.scientific.net/AMR.599
    DOI: 10.4028/www.scientific.net/AMR.599.86
    Language: Unknown
    Publisher: Trans Tech Publications, Ltd.
    Publication Date: 2012
    detail.hit.zdb_id: 2265002-7
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  • 3
    Online Resource
    Online Resource
    COVID-19-associated coagulopathy: thromboembolism prophylaxis and poor prognosis in ICU
    Springer Science and Business Media LLC ; 2021
    In:  Experimental Hematology & Oncology Vol. 10, No. 1 ( 2021-12)
    Details
    In: Experimental Hematology & Oncology, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2021-12)
    Abstract: Coronavirus disease 2019 (COVID-19) is associated with coagulation abnormalities which are indicators of higher mortality especially in severe cases. Methods We studied patients with proven COVID-19 disease in the intensive care unit of Jinyintan Hospital, Wuhan, China from 30 to 2019 to 31 March 2020. Results Of 180 patients, 89 (49.44 %) had died, 85 (47.22 %) had been discharged alive, and 6 (3.33 %) were still hospitalised by the end of data collection. A D-dimer concentration of 〉  0.5 mg/L on admission was significantly associated with 30 day mortality, and a D-dimer concentration of 〉  5 mg/L was found in a much higher proportion of non-survivors than survivors. Sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC) scoring systems were dichotomised as 〈  4 or ≥ 4 and 〈  5 or ≥ 5, respectively, and the mortality rate was significantly different between the two stratifications in both scoring systems. Enoxaparin was administered to 68 (37.78 %) patients for thromboembolic prophylaxis, and stratification by the D-dimer concentration and DIC score confirmed lower mortality in patients who received enoxaparin when the D-dimer concentration was 〉  2 than 〈  2 mg/L or DIC score was ≥ 5 than 〈  5. A low platelet count and low serum calcium concentration were also related to mortality. Conclusions A D-dimer concentration of 〉  0.5 mg/L on admission is a risk factor for severe disease. A SIC score of 〉  4 and DIC score of 〉  5 may be used to predict mortality. Thromboembolic prophylaxis can reduce mortality only in patients with a D-dimer concentration of 〉  2 mg/L or DIC score of ≥ 5.
    Type of Medium: Online Resource
    ISSN: 2162-3619
    URL: Article
    DOI: 10.1186/s40164-021-00202-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2669066-4
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  • 4
    Online Resource
    Online Resource
    The incidence, risk factors and prognosis of acute kidney injury in severe and critically ill patients with COVID-19 in mainland China: a retrospective study
    Springer Science and Business Media LLC ; 2020
    In:  BMC Pulmonary Medicine Vol. 20, No. 1 ( 2020-12)
    Details
    In: BMC Pulmonary Medicine, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Abstract: The clinical correlates, prognosis and determinants of acute kidney injury (AKI) in patients with coronavirus disease 2019 (Covid-19) remain largely unclear. Methods We retrospectively reviewed medical records of all adult patients with laboratory-confirmed Covid-19 who were admitted to the intensive care unit (ICU) between January 23rd 2020 and April 6th 2020 at Wuhan JinYinTan Hospital and The First Affiliated Hospital of Guangzhou Medical University. Results Among 210 patients, 131 were males (62.4%). The median Age was 64 years (IQR: 56–71). Of 92 (43.8%) patients who developed AKI during hospitalization, 13 (14.1%), 15 (16.3%) and 64 (69.6%) were classified as being at stage 1, 2 and 3, respectively. 54 patients (58.7%) received continuous renal replacement therapy. Age, sepsis, nephrotoxic drug, invasive mechanical ventilation and elevated baseline serum creatinine levels were associated with the occurrence of AKI. Renal recovery during hospitalization was identified among 16 patients with AKI (17.4%), who had a significantly shorter time from admission to AKI diagnosis, lower incidence of right heart failure and higher ratio of partial pressure of oxygen to the fraction of inspired oxygen. Of 210 patients, 93 deceased within 28 days of ICU admission. AKI stage 3, critical disease, greater Age and the lowest ratio of partial pressure of oxygen to the fraction of inspired oxygen being 〈  150 mmHg were independently associated with death. Conclusions Among patients with Covid-19, the incidence of AKI was high. Our findings of the risk factors of the development of AKI and factors associated with renal function recovery may inform clinical management of patients with critical illness of Covid-19.
    Type of Medium: Online Resource
    ISSN: 1471-2466
    URL: Article
    DOI: 10.1186/s12890-020-01305-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2059871-3
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  • 5
    Online Resource
    Online Resource
    Construction and Analysis of Competing Endogenous RNA Networks for Breast Cancer Based on TCGA Dataset
    Hindawi Limited ; 2020
    In:  BioMed Research International Vol. 2020 ( 2020-07-24), p. 1-10
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2020 ( 2020-07-24), p. 1-10
    Abstract: Background . Long noncoding RNAs (lncRNAs) act as competing endogenous RNAs for microRNAs in cancer metastasis. However, the roles of lncRNA-mediated competing endogenous RNA (ceRNA) networks for breast cancer (BC) are still unclear. Material and Methods . The expression profiles of mRNAs, lncRNAs, and miRNAs with BC were extracted from The Cancer Genome Atlas database. Weighted gene coexpression network analysis was conducted to extract differentially expressed mRNAs (DEmRNAs) that might be core genes. Through miRWalk, TargetScan, and miRDB to predict the target genes, an abnormal lncRNA-miRNA-mRNA ceRNA network with BC was constructed. The survival possibilities of mRNAs, miRNAs, and lncRNAs for patients with BC were determined by Kaplan-Meier survival curves and Oncomine. Results . We identified 2134 DEmRNAs, 1059 differentially expressed lncRNAs (DElncRNAs), and 86 differentially expressed miRNAs (DEmiRNAs). We then compose a ceRNA network for BC, including 72 DElncRNAs, 8 DEmiRNAs, and 12 DEmRNAs. After verification, 2 lncRNAs (LINC00466, LINC00460), 1 miRNA (Hsa-mir-204), and 5 mRNAs (TGFBR2, CDH2, CHRDL1, FGF2, and CHL1) were meaningful as prognostic biomarkers for BC patients. In the ceRNA network, we found that three axes were present in 10 RNAs related to the prognosis of BC, namely, LINC00466-Hsa-mir-204-TGFBR2, LINC00466-Hsa-mir-204-CDH2, and LINC00466-Hsa-mir-204-CHRDL1. Conclusion . This study highlighted lncRNA-miRNA-mRNA ceRNA related to the pathogenesis of BC, which might be used for latent diagnostic biomarkers and therapeutic targets for BC.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2020/4078596
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2698540-8
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  • 6
    Online Resource
    Online Resource
    Serum Metrnl is associated with the presence and severity of coronary artery disease
    Wiley ; 2019
    In:  Journal of Cellular and Molecular Medicine Vol. 23, No. 1 ( 2019-01), p. 271-280
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 23, No. 1 ( 2019-01), p. 271-280
    Abstract: Meteorin‐like (Metrnl) is a novel adipokine that is highly expressed in white adipose tissue. Metrnl stimulates energy expenditure and improves glucose tolerance in rodents. However, whether Metrnl plays a role in coronary artery disease ( CAD ) remains to be elucidated. The present study aimed to investigate the association of serum Metrnl with CAD in Chinese patients. A total of 193 patients with CAD and 156 control subjects were enrolled in this study. Serum Metrnl concentration was measured by enzyme‐linked immunosorbent assay. Anthropometric phenotypes, fasting glucose, serum lipids, and inflammatory cytokines were measured. Serum Metrnl was lower in CAD patients when compared to those controls (132.41 vs 173.17 pg/mL, P 〈 0.001). Serum Metrnl was negatively correlated with metabolic parameters, including body mass index, total cholesterol, and low‐density lipoprotein cholesterol as well as inflammatory markers including high‐sensitivity C‐reactive protein, IL ‐1β, and IL ‐11 even after adjustment for potential confounding variables ( P 〈 0.05). In multivariable logistic regression analyses, compared to those in the highest tertile of serum Metrnl levels, subjects in the lowest tertile had the highest risks for CAD (adjusted OR = 2.63, 95% CI = 1.46‐4.27, P = 0.001). After adjustment for potential confounding variables, serum Metrnl was also decreased as the number of stenosed vessels increased ( P 〈 0.001). Furthermore, decreased Metrnl level was negatively correlated with the severity of CAD quantified by the Gensini score. This first case‐control study shows significant associations of serum Metrnl with the presence and severity of CAD , suggesting Metrnl might be a new promising therapeutic target for CAD .
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.2019.23.issue-1
    DOI: 10.1111/jcmm.13915
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2076114-4
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  • 7
    Online Resource
    Online Resource
    Systemic Management for Nonmetastatic Castration-resistant Prostate Cancer : A Systematic Review and Network Meta-Analysis
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  American Journal of Clinical Oncology Vol. 43, No. 4 ( 2020-04), p. 288-297
    Details
    In: American Journal of Clinical Oncology, Ovid Technologies (Wolters Kluwer Health), Vol. 43, No. 4 ( 2020-04), p. 288-297
    Abstract: To indirectly compare the efficacy and safety of systemic therapies used for patients with nonmetastatic castration-resistant prostate cancer (nmCRPC). Methods: The relevant randomized controlled trials were retrieved from PubMed and the Cochrane Library. Network meta-analyses were used to compare multiple drugs simultaneously for the outcomes of nmCRPC. Direct evidence in trials and indirect evidence across trials were combined by the network meta-analyses to estimate the treatment efficiency. Outcome: Eight studies were included in our research. For prostate-specific antigen progression-free survival, the rate of progression was significantly decreased following apalutamide, enzalutamide, bicalutamide+dutasteride, and bicalutamide treatment compared with placebo. Compared with placebo treatment, metastases-free survival was significantly increased in patients who received apalutamide (hazard ratio [HR] : 0.28, 95% confidence interval [CI]: 0.23-0.35), enzalutamide (HR: 0.29, 95% CI: 0.24-0.35), and darolutamide (HR: 0.42, 95% CI: 0.35-0.50). Direct comparison showed significant survival benefits in patients who received second-generation anti-androgen therapy (apalutamide, enzalutamide, and darolutamide: HR: 0.74, 95% CI: 0.61-0.91) compared with patients who received placebo. With respect to metastases-free survival, based on SUCRA analysis, there was 80% and 78% probability that apalutamide and enzalutamide were preferred treatment, while darolutamide was likely to be second-best choice. Compared with placebo, all agents were not associated with significantly higher likelihood of serious adverse events and grade 3 to 4 adverse events. Conclusion: Our outcomes support equivalent efficacy and similar risk of adverse effects between apalutamide, enzalutamide, and darolutamide, supporting the use of these antiandrogen agents in high-risk of progression nmCRPC.
    Type of Medium: Online Resource
    ISSN: 0277-3732
    URL: Article
    DOI: 10.1097/COC.0000000000000660
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2043067-X
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  • 8
    Online Resource
    Online Resource
    Image_5.TIFF
    Frontiers Media SA ; 2023
    In:  Frontiers in Cardiovascular Medicine Vol. 9 ( 2023-1-9)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2023-1-9)
    Abstract: This study aimed to construct a radiomics signature of epicardial adipose tissue for predicting postoperative atrial fibrillation (POAF) after pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Methods We reviewed the preoperative computed tomography pulmonary angiography images of CTEPH patients who underwent PEA at our institution between December 2016 and May 2022. Patients were divided into training/validation and testing cohorts by stratified random sampling in a ratio of 7:3. Radiomics features were selected by using intra- and inter-class correlation coefficient, redundancy analysis, and Least Absolute Shrinkage and Selection Operator algorithm to construct the radiomics signature. The area under the receiver operating characteristic curve (AUC), calibration curve, and decision curve analysis (DCA) were used to evaluate the discrimination, calibration, and clinical practicability of the radiomics signature. Two hundred-times stratified five-fold cross-validation was applied to assess the reliability and robustness of the radiomics signature. Results A total of 93 patients with CTEPH were included in this study, including 23 patients with POAF and 70 patients without POAF. Five of the 1,218 radiomics features were finally selected to construct the radiomics signature. The radiomics signature showed good discrimination with an AUC of 0.804 (95%CI: 0.664–0.943) in the training/validation cohort and 0.728 (95% CI: 0.503–0.953) in the testing cohorts. The average AUC of 200 times stratified five-fold cross-validation was 0.804 (95%CI: 0.801–0.806) and 0.807 (95%CI: 0.798–0.816) in the training and validation cohorts, respectively. The calibration curve showed good agreement between the predicted and actual observations. Based on the DCA, the radiomics signature was found to be clinically significant and useful. Conclusion The radiomics signature achieved good discrimination, calibration, and clinical practicability. As a potential imaging biomarker, the radiomics signature of epicardial adipose tissue (EAT) may provide a reference for the risk assessment and individualized treatment of CTEPH patients at high risk of developing POAF after PEA.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fcvm.2022.1046931
    DOI: 10.3389/fcvm.2022.1046931.s001
    DOI: 10.3389/fcvm.2022.1046931.s002
    DOI: 10.3389/fcvm.2022.1046931.s003
    DOI: 10.3389/fcvm.2022.1046931.s004
    DOI: 10.3389/fcvm.2022.1046931.s005
    DOI: 10.3389/fcvm.2022.1046931.s006
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2781496-8
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  • 9
    Online Resource
    Online Resource
    Proteomic analysis of the effect of iptakalim on human pulmonary arterial smooth muscle cell proliferation
    Springer Science and Business Media LLC ; 2009
    In:  Acta Pharmacologica Sinica Vol. 30, No. 2 ( 2009-2), p. 175-183
    Details
    In: Acta Pharmacologica Sinica, Springer Science and Business Media LLC, Vol. 30, No. 2 ( 2009-2), p. 175-183
    Type of Medium: Online Resource
    ISSN: 1671-4083 , 1745-7254
    URL: Article
    DOI: 10.1038/aps.2008.30
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2009
    detail.hit.zdb_id: 2088565-9
    SSG: 15,3
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  • 10
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    Clinical characteristics of coronavirus disease 2019 (COVID-19) in patients out of Wuhan from China: a case control study
    Springer Science and Business Media LLC ; 2021
    In:  BMC Infectious Diseases Vol. 21, No. 1 ( 2021-12)
    Details
    In: BMC Infectious Diseases, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
    Abstract: A large-scale global outbreak of coronavirus disease-19 (COVID-19) out of Wuhan, from China, occurred in January 2020. To examine the clinical characteristics of COVID-19 in infected patients out of Wuhan, from China. Methods Thirteen patients were confirmed to be infected with novel coronavirus-2019 (2019-nCoV) between January 27 and February 8, 2020, in Baoji city, Shannxi, northwestern China. Epidemiological and clinical information, and computed to morphology imaging data from all COVID-19 patients were collected; cases were divided into two groups according to the severity of infection (mild or severe). Results Nine (9/13) COVID-19 patients exhibited mild disease severity, and defined as second-generation human-to-human transmission cases. Most patients (11/13) had a history of travel to or from Wuhan. There were no differences in sex and age between the mild and severe cases (all P   〉  0.05). A moderate degree of fever (11/13), cough (13/13), and fatigue (8/13) were common symptoms; however, there was no statistical difference between mild and severe cases in this regard (all P   〉  0.05). Oxyhemoglobin saturation and oxygenation index decreased, and C-reactive protein (CRP) and serum amyloid A (SAA) levels were elevated in all patients with COVID-19 infection, with statistically significant differences between those with severe disease and mild infection (all P   〈  0.05). Twelve of 13 COVID-19 patients exhibited changes in chest CT imaging features, and time course changes were different between mild and severe cases (all P   〈  0.05). Conclusion Most cases of COVID-19 infection were second-generation human-to-human transmissions from Wuhan and were mild in severity. The clinical characteristics of COVID-19 varied. Oxyhemoglobin saturation, oxygenation index, CRP and SAA levels, and CT features were reliable parameters to evaluate the severity of COVID-19 infection. However, a few patients with mild COVID-19 disease lacked typical characteristics such as fever and changes in CT imaging features.
    Type of Medium: Online Resource
    ISSN: 1471-2334
    URL: Article
    DOI: 10.1186/s12879-021-05897-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2041550-3
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