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  • 1
    Online Resource
    Online Resource
    Association of anemia and iron parameters with mortality among prevalent peritoneal dialysis patients in Taiwan: the AIM-PD study
    Springer Science and Business Media LLC ; 2022
    In:  Scientific Reports Vol. 12, No. 1 ( 2022-01-24)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-01-24)
    Abstract: In 1996, the National Health Insurance Administration of Taiwan applied a restrictive reimbursement criteria for erythropoiesis-stimulating agents (ESAs) use in patients with chronic kidney disease. The maximal ESAs dosage allowed by insurance is capped at 20,000 U of epoetin per month. Nephrologists avoided the use of high ESA dosages to achieve a hemoglobin level of 10–11 g/dL using iron supplementation. We assessed the association of anemia and iron parameters with mortality among peritoneal dialysis (AIM-PD) patients. A retrospective cohort study was conducted based on the Taiwan Renal Registry Data System. From January 1, 2000 to December 31, 2008, we enrolled 4356 well-nourished PD patients who were older than 20 years and had been receiving PD for more than 12 months. All patients were divided into subgroups according to different hemoglobin, ferritin and transferrin saturation (TSAT) values. Patients were followed until death or December 31, 2008. In a median 2.9-year study period, 694 (15.9%) patients died. By multivariate adjustment, a hemoglobin level lower than 10 g/dL was significantly associated with a higher risk for all-cause and cardiovascular deaths. Moreover, a serum ferritin level higher than 800 ng/mL was associated with a higher risk for all-cause deaths, and a TSAT value between 20 and 50% was associated with the lowest all-cause mortality. In conclusions, we recommend avoiding a low hemoglobin level and a serum ferritin level of more than 800 ng/mL and maintaining a TSAT value between 20 and 50%, as these conditions were associated with lower risks of all-cause mortality in the AIM-PD study.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-022-05200-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2615211-3
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  • 2
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    Vegan Diet Is Associated with a Lower Risk of Chronic Kidney Disease in Patients with Hyperuricemia
    MDPI AG ; 2023
    In:  Nutrients Vol. 15, No. 6 ( 2023-03-16), p. 1444-
    Details
    In: Nutrients, MDPI AG, Vol. 15, No. 6 ( 2023-03-16), p. 1444-
    Abstract: Hyperuricemia is a well-known risk factor for chronic kidney disease (CKD). Little is known about whether a vegetarian diet is associated with a lower risk of CKD in patients with hyperuricemia. From 5 September 2005, to 31 December 2016, we retrospectively included clinically stable patients with hyperuricemia who received health check-ups at Taipei Tzu Chi Hospital. All participants completed a dietary habits questionnaire to determine whether they were omnivorous, lacto-ovo vegetarian, or vegan. CKD was defined as an estimated glomerular filtration rate 〈 60 mL/min/1.73 m2 or the presence of proteinuria. A total of 3618 patients with hyperuricemia were recruited for this cross-sectional study, consisting of 225 vegans, 509 lacto-ovo vegetarians, and 2884 omnivores. After adjusting for age and sex, vegans had a significantly lower odds ratio (OR) of CKD than omnivores (OR, 0.62; p = 0.006). The OR of CKD remained significantly lower in vegans after adjusting for additional confounders (OR, 0.69; p = 0.04). Additionally, age (per year OR, 1.06; p 〈 0.001), diabetes mellitus (OR, 2.12; p 〈 0.001), hypertension (OR, 1.73; p 〈 0.001), obesity (OR, 1.24; p = 0.02), smoking (OR, 2.05; p 〈 0.001), and very high uric acid levels (OR, 2.08; p 〈 0.001) were independent risk factors for CKD in patients with hyperuricemia. Moreover, structural equation modeling revealed that a vegan diet was associated with a lower OR of CKD (OR, 0.69; p 〈 0.05). A vegan diet is associated with a 31% lower risk of CKD in patients with hyperuricemia. A vegan diet may be beneficial in reducing the occurrence of CKD in patients with hyperuricemia.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu15061444
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2518386-2
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  • 3
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    Vegetarian Diet Was Associated With a Lower Risk of Chronic Kidney Disease in Diabetic Patients
    Frontiers Media SA ; 2022
    In:  Frontiers in Nutrition Vol. 9 ( 2022-4-26)
    Details
    In: Frontiers in Nutrition, Frontiers Media SA, Vol. 9 ( 2022-4-26)
    Abstract: Diabetes mellitus (DM) is a pathological hyperglycemic state related to the dysregulation of insulin. Chronic kidney disease (CKD) is a common chronic complication in diabetic patients. A vegetarian diet could be one of the preventive strategies for the occurrence of CKD in patients with diabetes mellitus. However, it is still unknown whether a vegetarian diet lowers the occurrence of CKD in DM patients. Research Design and Methods This retrospective study was conducted at Taipei Tzu Chi Hospital from 5 September 2005 to 31 December 2016. Subjects with an HbA1c level & gt; 6.5% or previous history of diabetes mellitus elder than 40 years were grouped based on self-reported dietary habits (vegetarians, lacto-ovo vegetarians and omnivores) in the structured questionnaire. Structural equation modeling (SEM) was applied to estimate the direct and indirect effects of variables on the occurrence of chronic kidney disease. Results Among these 2,797 subjects, the participants were grouped into dietary habits as vegans ( n = 207), lacto-ovo vegetarians ( n = 941) and omnivores ( n = 1,649). The incidence of overall CKD was higher in the omnivore group [36.6% vs 30.4% (vegans) and 28.5% (lacto-ovo vegetarian), p & lt; 0.001]. In the SEM model, after adjusting for age and sex, the lacto-ovo vegetarian [OR: 0.68, 95% confidence interval (CI): 0.57–0.82] and vegan groups (OR 0.68, 95% CI: 0.49–0.94) were both associated with a lower risk of CKD occurrence than the omnivore group. The vegan diet and lacto-ovo diet lowered the risk related to a high BMI (OR: 0.45, p & lt; 0.001, OR: 0.58, p & lt; 0.001) and hyperuricemia (OR: 0.53, p & lt; 0.001; OR: 0.55, p & lt; 0.001) for the occurrence of CKD. Conclusion Vegetarian dietary habits were associated with a lower occurrence of CKD in DM patients.
    Type of Medium: Online Resource
    ISSN: 2296-861X
    URL: Article
    DOI: 10.3389/fnut.2022.843357
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2776676-7
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  • 4
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    Demographics of Scomberomorus commerson in the Central Taiwan Strait
    MDPI AG ; 2021
    In:  Journal of Marine Science and Engineering Vol. 9, No. 12 ( 2021-11-30), p. 1346-
    Details
    In: Journal of Marine Science and Engineering, MDPI AG, Vol. 9, No. 12 ( 2021-11-30), p. 1346-
    Abstract: The narrow-barred Spanish mackerel Scomberomorus commerson is an economically essential species; however, few studies have investigated its demographic structure in the northwestern Pacific, which includes Taiwan’s waters. This study examined the growth parameters, age composition, mortality, and sex ratio of S. commerson catches by examining sagittal otoliths and other biological data collected in a 3-year project from June 2018 to June 2021. The transverse sections of sagittal otoliths exhibited alternating translucent and opaque zones, in annual cycles, and this observation was validated by otolith edge analysis. Opaque zones began to form in October; the growth peaked in December and lasted until March. Growth parameters were estimated for female (L∞ = 144.1 cm fork length [FL], k = 0.39 y−1, to = −0.85 y) and male (L∞ = 136.0 cm FL, k = 0.32 y−1, to = −1.49 y) specimens. The maximum recorded FL, body weight, and age were 159.0 cm, 27 kg, and 9.2 y for female and 135.0 cm, 17.8 kg, and 7.2 y for male specimens. Rapid growth was observed for both sexes, with FL reaching 66.8 ± 14.2 cm in female specimens and 70.1 ± 11.0 cm in male specimens during the first year of life. An age–length key based on the direct otolith aging and FL dataset (N = 646) was used to estimate the age composition of 3-year catches measured at landing (N = 16,133). The results verified that the S. commerson currently caught in the central Taiwan Strait are mainly young fish aged 1+ to 2+ y. The estimated fishing mortality (0.27 y−1) and exploitation rate (0.30) suggested that overfishing was not occurring in this stock. The findings of this study have help ed clarify the population dynamics of the S. commerson in the Taiwan Strait, and the biological parameters reported herein can aid the management and conservation to ensure the sustainability of this species in this region.
    Type of Medium: Online Resource
    ISSN: 2077-1312
    URL: Article
    DOI: 10.3390/jmse9121346
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2738390-8
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  • 5
    Online Resource
    Online Resource
    Association of Vegetarian Diet with Chronic Kidney Disease
    MDPI AG ; 2019
    In:  Nutrients Vol. 11, No. 2 ( 2019-01-27), p. 279-
    Details
    In: Nutrients, MDPI AG, Vol. 11, No. 2 ( 2019-01-27), p. 279-
    Abstract: Chronic kidney disease (CKD) and its complications are major global public health issues. Vegetarian diets are associated with a more favorable profile of metabolic risk factors and lower blood pressure, but the protective effect in CKD is still unknown. We aim to assess the association between vegetarian diets and CKD. A cross-sectional study was based on subjects who received physical checkups at the Taipei Tzu Chi Hospital from 5 September 2005, to 31 December 2016. All subjects completed a questionnaire to assess their demographics, medical history, diet pattern, and lifestyles. The diet patterns were categorized into vegan, ovo-lacto vegetarian, or omnivore. CKD was defined as an estimated GFR 〈 60 mL/min/1.73 m2 or the presence of proteinuria. We evaluated the association between vegetarian diets and CKD prevalence by using multivariate analysis. Our study recruited 55,113 subjects. CKD was significantly less common in the vegan group compared with the omnivore group (vegan 14.8%, ovo-lacto vegetarians 20%, and omnivores 16.2%, P 〈 0.001). The multivariable logistic regression analysis revealed that vegetarian diets including vegan and ovo-lacto vegetarian diets were possible protective factors [odds ratios = 0.87 (0.77–0.99), P = 0.041; 0.84 (0.78–0.90), P 〈 0.001]. Our study showed a strong negative association between vegetarian diets and prevalence of CKD. If such associations are causal, vegetarian diets could be helpful in reducing the occurrence of CKD.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu11020279
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2518386-2
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  • 6
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    Association of nonalcoholic fatty liver and chronic kidney disease: An analysis of 37,825 cases from health checkup center in Taiwan
    Medknow ; 2020
    In:  Tzu Chi Medical Journal Vol. 32, No. 1 ( 2020), p. 65-
    Details
    In: Tzu Chi Medical Journal, Medknow, Vol. 32, No. 1 ( 2020), p. 65-
    Type of Medium: Online Resource
    ISSN: 1016-3190
    URL: Article
    DOI: 10.4103/tcmj.tcmj_233_18
    Language: English
    Publisher: Medknow
    Publication Date: 2020
    detail.hit.zdb_id: 2452925-4
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  • 7
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    Vegetarian diet and blood pressure in a hospital-base study
    Medknow ; 2018
    In:  Tzu Chi Medical Journal Vol. 30, No. 3 ( 2018), p. 176-
    Details
    In: Tzu Chi Medical Journal, Medknow, Vol. 30, No. 3 ( 2018), p. 176-
    Type of Medium: Online Resource
    ISSN: 1016-3190
    URL: Article
    DOI: 10.4103/tcmj.tcmj_91_17
    Language: English
    Publisher: Medknow
    Publication Date: 2018
    detail.hit.zdb_id: 2452925-4
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  • 8
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    The design of a thermoresponsive surface for the continuous culture of human pluripotent stem cells
    Elsevier BV ; 2019
    In:  Biomaterials Vol. 221 ( 2019-11), p. 119411-
    Details
    In: Biomaterials, Elsevier BV, Vol. 221 ( 2019-11), p. 119411-
    Type of Medium: Online Resource
    ISSN: 0142-9612
    URL: Article
    DOI: 10.1016/j.biomaterials.2019.119411
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 2004010-6
    SSG: 12
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  • 9
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    Trends in prevalence and incidence of diabetes mellitus from 2005 to 2014 in Taiwan
    Elsevier BV ; 2019
    In:  Journal of the Formosan Medical Association Vol. 118 ( 2019-11), p. S66-S73
    Details
    In: Journal of the Formosan Medical Association, Elsevier BV, Vol. 118 ( 2019-11), p. S66-S73
    Type of Medium: Online Resource
    ISSN: 0929-6646
    URL: Article
    DOI: 10.1016/j.jfma.2019.06.016
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 2250901-X
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  • 10
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    Add-on Protective Effect of Pentoxifylline in Advanced Chronic Kidney Disease Treated with Renin-Angiotensin-Aldosterone System Blockade - A Nationwide Database Analysis
    Springer Science and Business Media LLC ; 2015
    In:  Scientific Reports Vol. 5, No. 1 ( 2015-11-27)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2015-11-27)
    Abstract: A combination therapy of pentoxifylline with an angiotensin converting enzyme inhibitor (ACEI) or an angiotensin II receptor blocker (ARB) decreased proteinuria or glomerular filtration rate decline in early chronic kidney disease (CKD). Whether adding pentoxifylline to ACEI/ARB provides additional benefits on outcome is unclear in CKD stage 5 patients who have not yet received dialysis (CKD 5 ND). A prospective cohort study was conducted based on the Taiwan National Health Insurance Research Database. From January 1, 2000 to June 30, 2009, we enrolled 14,117 CKD 5 ND with serum creatinine levels 〉 6 mg/dL and hematocrit levels 〈 28% and who have been treated with ACEI/ARB. All patients were divided into pentoxifylline users and nonusers. Patient follow-up took place until dialysis, death before initiation of dialysis or December 31, 2009. Finally, 9,867 patients (69.9%) required long-term dialysis and 2,805 (19.9%) died before dialysis. After propensity score-matching, use of pentoxifylline was associated with a lower risk for long-term dialysis or death in ACEI/ARB users (HR, 0.94; 95% CI, 0.90–0.99) or ARB users (HR, 0.91; 95% CI, 0.85–0.97). In conclusion, pentoxifylline exhibited a protective effect in reducing the risk for the composite outcome of long-term dialysis or death in ACEI/ARB treated CKD 5 ND.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/srep17150
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2015
    detail.hit.zdb_id: 2615211-3
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