In:
Journal of Separation Science, Wiley, Vol. 39, No. 11 ( 2016-06), p. 2123-2128
Abstract:
A method was developed for the determination of nine volatile N‐nitrosamines in tobacco and smokeless tobacco products. The targets are N ‐nitrosodimethylamine, N ‐nitrosopyrrolidine, N ‐nitrosopiperidine, N ‐nitrosomorpholine, N ‐nitrosoethylmethylamine, N ‐nitrosodiethylamine, N ‐nitrosodipropylamine, N ‐nitrosobuylmethylmine, and N ‐nitrosodibutylamine. The samples were treated by dispersive solid‐phase extraction using 1 g of primary secondary amine and 0.5 g of carbon and then analyzed by gas chromatography with tandem mass spectrometry with an electron impact ion source. The recoveries for the targets ranged from 84 to 118%, with 〈 16% relative standard deviations at three spiking levels of 0.5, 1.25, and 2.5 ng/g. The limits of detection ranged from 0.03 to 0.15 ng/g. With the use of the proposed method, we detected the presence of six nitrosamines in the range of 0.4–30.7 ng/g. The study demonstrated that the method could be used as a rapid, convenient, and high‐throughput method for N‐nitrosamines analysis in tobacco matrix.
Type of Medium:
Online Resource
ISSN:
1615-9306
,
1615-9314
DOI:
10.1002/jssc.201600037
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2037737-X
detail.hit.zdb_id:
2047990-6
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