In:
Mini-Reviews in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 21, No. 13 ( 2021-09-23), p. 1718-1733
Abstract:
Metal-organic frameworks (MOFs) possess adjustable aperture, high load
capacities, tailorable structures, and excellent biocompatibilities for their use as drug delivery carries in cancer therapy. Until now, Zr-MOFs, in particular, combine optimal stability towards hydrolysis
and post synthetic modification with low toxicity, and are widely studied for their excellentbiological performance. Introduction: This review comprises the exploration of Zr-MOFs as drug delivery devices (DDSs)
with a focus on various new methods, including chemotherapy (CT), photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy (SDT), radiotherapy, immunotherapy, gene therapy
and related combined therapies, which all generate reactive oxygen species (ROS) to achieve high efficiency of tumor therapy. Conclusion: We described and summarized these pertinent examples of the therapeutic mechanisms
and highlighted the antitumor effects of their biological application both in vitro and in vivo. The perspectives on their future applications and the analogous challenge of the Zr-MOFs materials are given.
Type of Medium:
Online Resource
ISSN:
1389-5575
DOI:
10.2174/1389557521666210105111850
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2021
SSG:
15,3
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