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  • 1
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    The role of stem cell metabolites derived from placenta for skin regeneration: An in vitro study
    DiscoverSys, Inc. ; 2019
    In:  Bali Medical Journal Vol. 8, No. 1 ( 2019-04-01), p. 354-
    Details
    In: Bali Medical Journal, DiscoverSys, Inc., Vol. 8, No. 1 ( 2019-04-01), p. 354-
    Materialart: Online-Ressource
    ISSN: 2302-2914 , 2089-1180
    URL: Article
    DOI: 10.15562/bmj.v8i1.1387
    Sprache: Unbekannt
    Verlag: DiscoverSys, Inc.
    Publikationsdatum: 2019
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
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    Comparative efficacy of topical Adipocyte-derived Mesenchymal Stem Cells-Conditioned Medium (ADMSC-CM) and Amniotic Membrane Mesenchymal Stem Cells-Conditioned Medium (AMSC-CM) on chronic plantar ulcers in leprosy: a randomized controlled trial
    DiscoverSys, Inc. ; 2021
    In:  Bali Medical Journal Vol. 10, No. 3 ( 2021-12-10), p. 958-963
    Details
    In: Bali Medical Journal, DiscoverSys, Inc., Vol. 10, No. 3 ( 2021-12-10), p. 958-963
    Kurzfassung: Introduction: Chronic Plantar Ulcer of Leprosy (CPUL), one of the debilitating disabilities and complications, poses a treatment challenge. Utilization of stem cells, specifically adipocyte-derived mesenchymal stem cells-conditioned medium (ADMSC-CM) and amniotic membrane mesenchymal stem cells-conditioned medium (AMSC-CM), may serve as a novel therapeutic option. This study aims to compare the efficacy of topical ADMSC-CM, topical AMSC-CM, and farmazertin gauze dressing (FGD) only on the healing of CPUL.Methods: In this randomized controlled trial, our study recruited 54 subjects with CPUL. Subjects were randomly assigned to topical ADMSC-CM (n = 16), topical AMSC-CM (n = 22), or FGD (n = 16) applied every three days for up to 8 weeks. Data were analyzed using SPSS version 20 for Windows.Results: Healing percentage increased each week in all groups. Statistic differences between groups (p 〈 0.05) were observed for ulcer mean size and depth reduction from week three onwards. No adverse reactions or complications were reported. At the end of the study, based on clinically improved ulcers, topical ADMSC-CM (100.0%) were superior in improving the healing of CPULs compared to topical AMSC-CM (54.55%) and FGD only (50.0%).Conclusion: ADMSC-CM and AMSC-CM are potential therapeutic agents in the management of CPUL, with ADMSC-CM being superior in overall ulcer improvement.
    Materialart: Online-Ressource
    ISSN: 2302-2914 , 2089-1180
    URL: Article
    DOI: 10.15562/bmj.v10i3.2747
    Sprache: Unbekannt
    Verlag: DiscoverSys, Inc.
    Publikationsdatum: 2021
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
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    Fractional erbium laser in vaginal laxity
    DiscoverSys, Inc. ; 2021
    In:  Bali Medical Journal Vol. 10, No. 2 ( 2021-08-30), p. 899-903
    Details
    In: Bali Medical Journal, DiscoverSys, Inc., Vol. 10, No. 2 ( 2021-08-30), p. 899-903
    Kurzfassung: Vaginal laxity is a condition that often occurs in women, especially after vaginal delivery, and its prevalence increases with age. This review aimed to explain the role of fractional Erbium laser as a new modality for vaginal laxity management. The typical symptom reported by patients was reduced vaginal sensation. One therapeutic option for vaginal laxity is fractional Erbium laser: yttrium aluminum garnet (Er: YAG) at 2,940 nm frequencies. The laser's thermal stimulation of the dermis appears to stimulate the formation of new collagen, resulting in the thickening of the vaginal mucosa. Previous studies on Er: YAG fractional lasers have shown satisfactory results with minimal side effects.
    Materialart: Online-Ressource
    ISSN: 2302-2914 , 2089-1180
    URL: Article
    DOI: 10.15562/bmj.v10i2.2594
    Sprache: Unbekannt
    Verlag: DiscoverSys, Inc.
    Publikationsdatum: 2021
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
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    Patient preferences for surgery or non-surgery for the treatment of clavus and callus at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
    DiscoverSys, Inc. ; 2022
    In:  Bali Medical Journal Vol. 11, No. 1 ( 2022-04-18), p. 288-292
    Details
    In: Bali Medical Journal, DiscoverSys, Inc., Vol. 11, No. 1 ( 2022-04-18), p. 288-292
    Kurzfassung: Background: Clavus and callus are common hyperkeratotic lesions that can be very painful and affect the quality of life. The clinicians are faced with various factors affecting the resolution of the lesion, and no treatment has been considered ideal. Surgical has been preferable to conservative treatment but is still more likely to increase patients' desirability due to great discomfort. This study aims to evaluate the factors contributing to the resolution of callus and clavus. Methods: Retrospective analysis was done on 25 medical records of patients who met the inclusion criteria. Factors contributing to the lesion resolution were identified and analyzed using the SPSS version 17 program. Result: Among 25 (33.7%) patients recruited for the study, 13 were (52%) male and 12 (48%) female. The most common types of lesions were clavus (20 [80%]). In both cases, the distribution of lesion locations was mostly found in the lower extremities (20 [80%] ). Excision was performed in 21 cases (84%), and 20 patients (80%) achieved resolution. Treatment modalities were found to be a factor that had a significant relation to the resolution of the lesion after receiving treatment (p = 0.003; Spearman test). Conclusion: Treatment of callus and clavus has shown satisfactory results in our center. Excision was found to be the most preferred method, with 80% resolution observed during 1 month. The treatment choice was found to be significantly related to the resolution of the lesion after receiving therapy.
    Materialart: Online-Ressource
    ISSN: 2302-2914 , 2089-1180
    URL: Article
    DOI: 10.15562/bmj.v11i1.3264
    Sprache: Unbekannt
    Verlag: DiscoverSys, Inc.
    Publikationsdatum: 2022
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
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    Profile of melasma patients in dermatology and venerology outpatient clinic Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
    DiscoverSys, Inc. ; 2022
    In:  Bali Medical Journal Vol. 11, No. 1 ( 2022-03-28), p. 166-173
    Details
    In: Bali Medical Journal, DiscoverSys, Inc., Vol. 11, No. 1 ( 2022-03-28), p. 166-173
    Kurzfassung: Background: Melasma is characterized by symmetrical brownish macules with well-defined borders. The etiology of melasma is still unknown, but factors that are thought to influence include genetic predisposition, ultraviolet radiation, hormonal factors, thyroid disorders, use of cosmetics, and drugs. This study aimed to determine the epidemiological data, evaluate risk factors, management, and follow-up in new melasma patients. Methods: The medical records of patients with melasma attending Dermatology and Venereology Outpatient Clinic over a 4-year period from 2015 to 2018 were analyzed retrospectively for this descriptive, observational study. Data were analyzed using SPSS version 23 for Windows. Results: This study found 739 new melasma patients from January 2015 to December 2018, with the proportion of women 734 patients (99.3%) more than men only 5 patients (0,7%). The age of most patients who were treated was 46-55 years in 320 patients (43.3%), with the highest age of onset being 37-45 years in 308 patients (41.7%). About 561 patients (75.9%) had a melasma duration of more than 1 year. The most common job of melasma patients was housewives in 366 patients (49.5%). The most frequent risk factor for melasma was ultraviolet radiation in 258 patients (34.9%). The most common melasma was malar type in 482 patients (65.2%) and mixed melasma in 617 patients (83.4%). The most widely administered therapy was sunscreen in 735 patients (99.5%) and Tretinoin 0.05% in 235 patients (31.8%). Most patients did not make repeat visits as many as 448 patients (60.6%). Conclusion: The most common disease in women of childbearing age with ultraviolet radiation is the most precipitating risk factor. The low number of patient repeat visits can be caused by a lack of doctor education or a lack of patient adherence to treatment due to chronic and recurrent diseases.
    Materialart: Online-Ressource
    ISSN: 2302-2914 , 2089-1180
    URL: Article
    DOI: 10.15562/bmj.v11i1.3182
    Sprache: Unbekannt
    Verlag: DiscoverSys, Inc.
    Publikationsdatum: 2022
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
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    Tatalaksana laser CO2 pada hiperplasia kelenjar sebasea: laporan kasus
    DiscoverSys, Inc. ; 2022
    In:  Intisari Sains Medis Vol. 13, No. 3 ( 2022-12-07), p. 703-705
    Details
    In: Intisari Sains Medis, DiscoverSys, Inc., Vol. 13, No. 3 ( 2022-12-07), p. 703-705
    Kurzfassung: Background: Sebaceous gland hyperplasia is a benign skin disorder in the form of macules or papules which are generally 〈 1 mm in size, skin color or yellowish at the mouth of the pilosebaceous gland follicle.1 This disorder can cause cosmetic morbidity and psychosocial impacts for patients. There are various treatment modalities for sebaceous gland hyperplasia associated with the risk of pain, depigmentation, bleeding during the procedure, scarring, and recurrence. CO2 laser is one of the therapeutic approaches that are considered effective and safe. Case: A female patient came with the chief complaint of lumpy skin-colored lumps on the back of the ear to the left neck that had increased in number and had not been painful since about 4 years ago. Histopathological examination was performed on the lump showing hyperplasia of the sebaceous glands. The patient was treated with 2 CO2 Laser sessions with an even skin surface result. Observations made within 9 months after the procedure did not reveal any recurrence of the lesion. Conclusion: CO2 laser can be an effective and safe alternative therapy for sebaceous gland hyperplasia.   Latar Belakang: Hiperplasia kelenjar sebasea adalah kelainan jinak kulit berupa makula atau papula yang umumnya berukuran 〈 1 mm sewarna kulit atau kekuningan di muara folikel kelenjar pilosebasea.1 Kelainan ini dapat menimbulkan morbiditas kosmetik dan dampak psikososial bagi pasien. Terdapat berbagai modalitas tatalaksana hiperplasia kelenjar sebasea yang berhubungan dengan risiko nyeri, depigmentasi, perdarahan selama prosedur, skar, hingga kekambuhan. Laser CO2 merupakan salah satu pendekatan terapi yang dianggap efektif dan aman. Kasus: Pasien wanita datang dengan keluhan utama benjolan bergerombol sewarna kulit pada telinga bagian belakang hingga leher kiri yang bertambah banyak dan tidak nyeri sejak kurang lebih 4 tahun yang lalu. Pemeriksaan histopatologi dilakukan pada benjolan menunjukkan hasil hiperplasia kelenjar sebasea. Pasien diterapi dengan 2 sesi Laser CO2 dengan hasil permukaan kulit rata. Observasi yang dilakukan dalam 9 bulan paska tindakan tidak didapatkan rekurensi pada lesi. Simpulan: Laser CO2 dapat menjadi alternatif terapi pada hiperplasia kelenjar sebasea yang efektif dan aman.
    Materialart: Online-Ressource
    ISSN: 2503-3638 , 2089-9084
    URL: Article
    DOI: 10.15562/ism.v13i3.1543
    Sprache: Unbekannt
    Verlag: DiscoverSys, Inc.
    Publikationsdatum: 2022
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
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    Topical Epigallocatechin Gallate (EGCG) 1% for Chronic Plantar Ulcers in Leprosy
    Universitas Airlangga ; 2020
    In:  Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32, No. 2 ( 2020-07-31), p. 134-
    Details
    In: Berkala Ilmu Kesehatan Kulit dan Kelamin, Universitas Airlangga, Vol. 32, No. 2 ( 2020-07-31), p. 134-
    Kurzfassung: Background: Chronic plantar ulcers in leprosy (CPUL) increase morbidity, increase medical costs, cause loss of productivity, and decrease quality of life. CPUL is a severe complication of leprosy disease with a 10-20% incidence. In general, CPUL consume a significant amount of time to heal. Green tea extract contains high amount of Epigallocatechin gallate (EGCG). EGCG functions as antiinflammatory, antimicrobial, and immunomodulator. This suggests that EGCG is effective for dermal wound treatment by facilitating reepithelialization. Purpose: To investigate the effect of topical EGCG 1% on the CPUL healing process. Methods: The topical EGCG 1% were applied every three days for eight weeks. Size of the ulcers, side effects and possible complications were monitored weekly. Result: There were significant clinical and statistical differences in the size and depth of the ulcers (p=0.000), as observed in the EGCG group. There was no side effect and complication found. Conclusions: Topical EGCG 1% was effective for CPUL healing. Sixty three point six percent of the ulcers were clinically healed, 31.8% demonstrated improvement, and 4.6% no effect was observed.
    Materialart: Online-Ressource
    ISSN: 2549-4082 , 1978-4279
    URL: Article
    DOI: 10.20473/bikk.V32.2.2020.134-140
    Sprache: Unbekannt
    Verlag: Universitas Airlangga
    Publikationsdatum: 2020
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
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    The Demography, Clinical Characteristics, and White Blood Analysis of Leprosy Reactions in Multibacillary Leprosy: A Retrospective Study
    Universitas Airlangga ; 2021
    In:  Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33, No. 3 ( 2021-11-30), p. 187-
    Details
    In: Berkala Ilmu Kesehatan Kulit dan Kelamin, Universitas Airlangga, Vol. 33, No. 3 ( 2021-11-30), p. 187-
    Kurzfassung: Background: Leprosy is a neglected tropical disease caused by chronic granulomatous infection of Mycobacterium leprae. Indonesia ranks third in new case findings, with 84% of the case being multibacillary (MB) leprosy. MB leprosy cases have a higher risk of leprosy reactions and physical disabilities that decrease quality of life. Purpose: To determine the demographic, clinical characteristics, and white blood analysis of newly diagnosed MB leprosy patients, especially concerning leprosy reactions. Methods: This is a descriptive retrospective study with a cross-sectional design that describe the following data: domicile, gender, age, treatment status, disabilities, body mass index (BMI); bacterial index (BI), morphological index (MI), white blood cell (WBC) and differential counts, and thrombocyte count. Result: This study included 176 adult MB cases, predominantly male aged 20–39 years old with average BMI, lived in Surabaya with negative history of multi-drug therapy, disability, BI, nor MI. The grade 2 disability (G2D) percentage in this study setting than in Indonesia (10.7% vs. 6.43%). The WBCs, especially neutrophil count, was higher in T2R group. Monocyte and lymphocyte counts were relatively similar. There was an increase in thrombocyte count in leprosy reaction groups. Conclusion: MB leprosy in the endemic area, which is more commonly found in productive-aged male, displayed higher G2D than global Indonesia population. Thus denotes the importance of active case findings. The difference in blood analysis characteristics between MB leprosy with and without reactions may serve as the foundation for future study.
    Materialart: Online-Ressource
    ISSN: 2549-4082 , 1978-4279
    URL: Article
    DOI: 10.20473/bikk.V33.3.2021.187-193
    Sprache: Unbekannt
    Verlag: Universitas Airlangga
    Publikationsdatum: 2021
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
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    In Vitro Antifungal Susceptibility Testing of Tea Tree Oil (TTO) 5% Compared with Nystatin against Candida sp. as Important Agent of Oral Candidiasis in HIV/AIDS Patients
    Universitas Airlangga ; 2020
    In:  Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32, No. 3 ( 2020-11-30), p. 189-
    Details
    In: Berkala Ilmu Kesehatan Kulit dan Kelamin, Universitas Airlangga, Vol. 32, No. 3 ( 2020-11-30), p. 189-
    Kurzfassung: Background: Oral candidiasis is the most common clinical manifestation in a person infected with HIV which has been linked with the severity of the disease. Candida albicans responsible for most oral candidiasis. The increased resistance to the available antifungal drugs can reduce the efficacy of therapy. Therefore, it will be crucial to discover novel antifungal agents. One of them is tea tree oil (TTO) or Melaleuca alternifolia which has a potent antifungal effect to inhibit the growth of Candida sp.  Purpose: To evaluate the antifungal susceptibility of TTO 5% compared with nystatin against Candida sp. taken from HIV/AIDS patients. Methods: The study assessed the antifungal effect of TTO 5% and nystatin against 33 isolates of Candida sp. that was isolated from the oral cavity of 30 HIV/AIDS patients in Dr. Soetomo General Academic Teaching Hospital Surabaya, Indonesia. Antifungal susceptibility was evaluated by the disc diffusion method. The diameter of the inhibition zone was determined as the result of this study. Result: The most strains found in this study was Candida albicans (84.8%). The mean inhibition zone of nystatin against all strains was 23.24 mm whether it was 17.55 mm for TTO 5%. The inhibition zone of both TTO 5% and nystatin in Candida non-albicans were tended to be higher than in Candida albicans. It revealed that the inhibition zone of TTO 5% significantly lower than nystatin (P = 0.00; P 〈 0.05).Conclusion: Therefore, the antifungal susceptibility of nystatin was significantly higher than TTO 5% against Candida albicans and non-albicans.
    Materialart: Online-Ressource
    ISSN: 2549-4082 , 1978-4279
    URL: Article
    DOI: 10.20473/bikk.V32.3.2020.189-194
    Sprache: Unbekannt
    Verlag: Universitas Airlangga
    Publikationsdatum: 2020
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
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    The Profile of Psoriasis Vulgaris Patients: A Descriptive Study
    Universitas Airlangga ; 2021
    In:  Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33, No. 3 ( 2021-11-30), p. 173-
    Details
    In: Berkala Ilmu Kesehatan Kulit dan Kelamin, Universitas Airlangga, Vol. 33, No. 3 ( 2021-11-30), p. 173-
    Kurzfassung: Background: Psoriasis is a skin disease that occurs due to proliferation and differentiation disturbances of the epidermis. This chronic condition often reduces the human quality of life. There have been studies investigating psoriatic patient profiles and treatments, but few are conducted in Surabaya. Hence, those studies cannot fully represent the population demographic in Surabaya. Purpose: To investigate the prevalence of psoriasis vulgaris and the sociodemographic profile of the patients in Dr Soetomo General Academic Hospital. Methods: This was a Retrospective study psoriasis vulgaris patients in January 2016–December 2018. The data were collected by retrieving Electronic Medical Records (EMR) as secondary data. Result: The psoriasis vulgaris prevalence of outpatients was 0.46% and 4.59% in inpatients. Most study subjects were adults aged 18 and above (98.1%), most of the patients were obese (46.3%), the most common provoking factor was focal tooth infection (33.8%) and stress (28.8%), and none reported family history of psoriasis. Conclusion: Some results are similar to other studies conducted in Surabaya, which were the obesity and Type 2 Diabetes Mellitus (DM) being strong a factor to psoriasis development. However, the result on psoriasis family history was not in line with other studies.
    Materialart: Online-Ressource
    ISSN: 2549-4082 , 1978-4279
    URL: Article
    DOI: 10.20473/bikk.V33.3.2021.173-181
    Sprache: Unbekannt
    Verlag: Universitas Airlangga
    Publikationsdatum: 2021
    Standort Signatur Einschränkungen Verfügbarkeit
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