In:
Cerebrovascular Diseases, S. Karger AG, Vol. 49, No. 1 ( 2020), p. 88-96
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The statistical association between a short-term rise in low-density lipoprotein cholesterol (LDL-C) levels and the short-term outcome of acute ischemic stroke remains unknown. We aimed to evaluate the association in acute ischemic stroke patients during hospitalization. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Patients with acute ischemic stroke who received statin at discharge were enrolled in this multicenter registry study. LDL-C values were measured on the first day after admission and on the day before discharge to determine the rise in LDL-C levels. Poor outcome was defined as a modified Ranking Scale score ≥2 at discharge. The National Institutes of Health Stroke Scale increase from admission to discharge by 2 points was defined as clinical deterioration. Logistic regression analyses were used to analyze the relationship between LDL-C rise during hospitalization and poor outcome at discharge. Variables that were significantly different between the LDL-C rise and LDL-C fall groups were considered in adjustment for confounding variables in model 1. Age, sex, and those variables in model 1 were considered in adjustment for confounding variables in model 2. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among the 676 patients, 110 (16.3%) showed a rise in LDL-C levels during hospitalization. Multivariate analyses showed that LDL-C at admission & #x3c;1.6 mmol/L was significantly correlated with LDL-C rise during hospitalization ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). There were significantly more patients with a poor outcome in the “LDL-C rise” group than in the “LDL-fall” group ( 〈 i 〉 p 〈 /i 〉 = 0.002). Multiple models consistently showed that LDL-C rise increased the risk of a poor outcome at discharge in model 1 (OR [95% CI] 1.351 [1.059–1.723] , 〈 i 〉 p 〈 /i 〉 = 0.016) and model 2 (OR [95% CI] 1.370 [1.071–1.751] , 〈 i 〉 p 〈 /i 〉 = 0.012). LDL-C rise also increased the risk of clinical deterioration, although its 〈 i 〉 p 〈 /i 〉 value only was 0.043 in model 1 and 0.048 in model 2. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Rise in LDL-C during hospitalization from acute ischemic stroke is an independent predictor of poor outcome at discharge. In particular, patients with lower LDL-C values at admission are a higher at risk, and LDL-C in these patients should thus be monitored while in hospital.
Type of Medium:
Online Resource
ISSN:
1015-9770
,
1421-9786
Language:
English
Publisher:
S. Karger AG
Publication Date:
2020
detail.hit.zdb_id:
1482069-9
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