In:
Experimental and Clinical Endocrinology & Diabetes, Georg Thieme Verlag KG, Vol. 129, No. 10 ( 2021-10), p. 729-739
Abstract:
Background Diabetic nephropathy (DN) is the
leading cause of end-stage renal disease (ESRD). DN has many pathological changes, but tubular
injury is considered to be a crucial pathological feature and plays a key role in the progression of
DN. Accumulating studies have confirmed that Luteolin (3,4,5,7-tetrahydroxyflavone, Lut)
possesses anti-inflammatory and antioxidant activities, which may play a role in kidney
protection in DN. Objectives This paper described the effects
of Lut on appropriated tubular injury in the kidneys of db/db mice and searched the possible
mechanisms underlying the kidney protection effect in DN. Methods Twelve-week-old male C57BL/6 J
db/db and C57BL/6 J db/m mice were used for the animal experiments. They were organized into the
following five groups for the animal experiments: a db/m group (control, n=6); a db/db group(n=8) ; a db/db group receiving Lut (10 mg/kg/day,
n=8)treatment by oral gavage; a db/db group receiving stattic (a selective STAT3
inhibitor,50 mg/Kg/day, n=8) treatment by oral gavage and a db/db group receiving both stattic
and Lut treatment by oral gavage. Results In this study, we found that Lut
might ameliorate glomerular sclerosis and interstitial fibrosis in DN mouse models through
inhibiting the inflammatory response and oxidative stress. And it might play its biological function
mainly through repressing the STAT3 activation. Conclusions Lut attenuates DN mainly via
suppression of inflammatory response and oxidative response. STAT3 pathway is the potential target,
which ultimately reduces renal fibrosis and delays the progress of DN.
Type of Medium:
Online Resource
ISSN:
0947-7349
,
1439-3646
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2021
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