In:
FEBS Letters, Wiley, Vol. 546, No. 2-3 ( 2003-07-10), p. 265-270
Abstract:
Epigallocatechin gallate (EGCG), a major component of green tea, has been previously shown to inhibit platelet aggregation. The effects of other green tea catechins on platelet function are not known. Pre‐incubation with EGCG concentration‐dependently inhibited thrombin‐induced aggregation and phosphorylation of p38 mitogen‐activated protein kinase and extracellular signal‐regulated kinases‐1/2. In contrast EGCG stimulated tyrosine phosphorylation of platelet proteins, including Syk and SLP‐76 but inhibited phosphorylation of focal adhesion kinase. Other catechins did not inhibit platelet aggregation. Interestingly, when EGCG was added to stirred platelets, a tyrosine kinase‐dependent stimulation of platelet aggregation was observed. The two other catechins containing a galloyl group in the 3′ position (catechin gallate, epicatechin gallate) also stimulated platelet aggregation, while catechins without a galloyl group (catechin, epicatechin) or the catechin with a galloyl group in the 2′ position (epigallocatechin) did not.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(03)00599-4
Language:
English
Publisher:
Wiley
Publication Date:
2003
detail.hit.zdb_id:
1460391-3
SSG:
12
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