In:
Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 4, No. 7 ( 2015-07-17)
Abstract:
Nonalcoholic fatty liver disease ( NAFLD ) is independently associated with QT prolongation among patients with diabetes. It has not yet been determined whether this association remains valid in the general population. We designed an observational study to explore this association. Methods and Results We conducted a cross‐sectional analysis of 31 116 consecutive participants in our health management program. Heart rate–corrected QT ( QT c) interval was derived from 12‐lead electrocardiography and by Bazett's formula. NAFLD was diagnosed by abdominal ultrasonography and classified as none, mild, moderate , or severe , according to the ultrasonographic criteria. A multivariable linear regression model was fitted for the association between QT c interval and potential predictors (including demographic, anthropometric, biochemical factors, and comorbidities). Multivariable logistic regression analyses were fitted to assess the association between the severity of NAFLD and QT c prolongation, with the adjustment of significant predictors derived from multivariable linear regression. The mean QT c interval was 421.3 ms ( SD 45.4 ms). In the multivariable linear regression analyses, mild, moderate, and severe NAFLD were associated with increases of 2.55, 6.59, and 12.13 ms, respectively, in QT c interval compared with no NAFLD (all P 〈 0.001). In the multivariable logistic regression analyses, mild, moderate, and severe NAFLD were associated with an increased risk for QT c prolongation, with odds ratios of 1.11 (95% CI: 1.01 to 1.21, P 〈 0.05), 1.61 (95% CI: 1.36 to 1.9, P 〈 0.001), and 1.31 (95% CI: 1.16 to 2.24, P 〈 0.01), respectively, in women, and 1.11 (95% CI: 1.01 to 1.21, P 〈 0.05), 1.39 (95% CI: 1.22 to 1.59, P 〈 0.001), and 1.87 (95% CI: 1.16 to 2.24, P 〈 0.001), respectively, in men, after adjusting for predictors known to be associated with the QT c interval. The association remained significant among subgroups with or without diabetes. Conclusions The severity of NAFLD was associated with a higher risk for QT c prolongation in the general population with and without diabetes.
Type of Medium:
Online Resource
ISSN:
2047-9980
DOI:
10.1161/JAHA.115.001820
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2015
detail.hit.zdb_id:
2653953-6
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