In:
Molecular Carcinogenesis, Wiley, Vol. 51, No. S1 ( 2012-10)
Abstract:
Hepatocellular carcinoma (HCC) is a disease of multiple etiologies caused by the accumulation of genetic and epigenetic defects. Current evidence indicates that the transforming growth factor beta (TGF‐β) signaling pathway has a significant impact on different cellular process. Members of the TGF‐β superfamily (TGF‐β1, the type I TGF‐β receptor [TβRI], type II TGF‐β receptor [TβRII] , and type III TGF‐β receptor]) play an important role in tumorigenesis. Numerous studies show that genetic polymorphisms in TGF‐β superfamily genes are associated with HCC in East Asian populations. We studied 16 single nucleotide polymorphisms (SNPs) in four genes ( TGF‐β1 , TβRI , TβRII , and TβRIII ) to examine their associations with hepatocarcinogenesis. A total of 1228 Chinese Han participants were enrolled in the study (881 control participants who were negative for all hepatitis B virus [HBV] serum markers and 347 case participants with HBV‐related HCC). Genotyping was conducted using the TaqMan method. The results showed that the frequency of the rs1805110 T allele was significantly higher in the case group than in the control group ( P = 0.034). After stratification, the results for rs1805110 remained significant in male participants ( P = 0.005), but there was no statistical difference in females. In males, the frequency of the C‐C‐G‐C‐A haplotype resulting from SNPs rs1805110, rs2810904, rs1805112, rs284878, and rs1804506 in TβRIII was significantly lower in the case group than in the control group ( P = 0.001), whereas the reverse was true for the T‐C‐G‐C‐A haplotype ( P = 0.036). We conclude that the rs1805110T allele is associated with susceptibility to HBV‐related HCC in males. © 2012 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
0899-1987
,
1098-2744
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2001984-1
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