In:
Journal of Healthcare Engineering, Hindawi Limited, Vol. 2022 ( 2022-2-16), p. 1-10
Abstract:
Background. Many researchers have confirmed that miRNAs are involved in the pathogenesis of gastric cancer (GC). This study focused on investigating the specific functions of miR-139-5p in GC. Methods. MiR-139-5p and TPD52 expressions were observed by qRT-PCR or western blot in GC. The functional mechanism of miR-139-5p was explored by the luciferase reporter assay, transwell assay, and MTT assay. Results. MiR-139-5p downregulation and TPD52 upregulation were detected in GC. Adverse clinical features and prognosis in GC patients were related to low miR-139-5p expression. MiR-139-5p overexpression restrained GC cell proliferation and metastasis. Furthermore, miR-139-5p directly targeted TPD52. TPD52 silencing blocked GC progression. And TPD52 upregulation weakened the antitumor effect of miR-139-5p in GC. Conclusion. MiR-139-5p inhibits GC cell proliferation and metastasis through downregulating TPD52.
Type of Medium:
Online Resource
ISSN:
2040-2309
,
2040-2295
DOI:
10.1155/2022/4033373
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2022
detail.hit.zdb_id:
2545054-2
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