In:
International Journal of Cancer, Wiley, Vol. 142, No. 9 ( 2018-05), p. 1805-1816
Abstract:
What's new? TFF1 is a well‐established gastric‐specific tumor suppressor gene, but the mechanisms underlying its expression and role in gastric tumorigenesis remain unclear. This study shows that rs3761376 AA in the promoter region of TFF1 can reduce TFF1 expression by affecting the binding affinity of estrogen receptor 1, thereby increasing the risk of gastric cancer. Moreover, rs3761376 AA was associated with worse prognosis among patients receiving 5‐FU based chemotherapy after surgery, with TFF1 increasing the chemosensitivity of 5‐FU by modulating NF‐κB targeted genes. The findings suggest that TFF1 rs3761376 may be used as a potential biomarker for gastric cancer diagnosis and prognosis.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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