In:
BMC Cardiovascular Disorders, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-04-03)
Abstract:
Left atrial (LA) appendage flow velocity (LAAFV) is a classic but invasive predictor of thromboembolic events in patients with atrial fibrillation (AF). We aimed to explore the usefulness of LA diameter (LAD) combined with CHA 2 DS 2 -VASc score, which is easily available and non-invasive, as a novel score for predicting a decrease in LAAFV in non-valvular AF (NVAF). Methods In total, 716 consecutive NVAF patients who underwent transesophageal echocardiography were divided into the decreased LAAFV ( 〈 0.4 m/s) and preserved LAAFV (≥ 0.4 m/s) groups. Results The decreased LAAFV group had a larger LAD and a higher CHA 2 DS 2 -VASc score than the preserved LAAFV group ( P 〈 0.001). Multivariate linear regression indicated that brain natriuretic peptide (BNP) concentration, persistent AF, LAD, and CHA 2 DS 2 -VASc score were remained inversely associated with LAAFV. Moreover, multivariate logistic regression revealed that BNP concentration (odds ratio [OR] 1.003, 95% confidence interval [CI] 1.001–1.005, P = 0.003), persistent AF (OR 0.159, 95% CI 0.102–0.247, P 〈 0.001), and LAD (OR 1.098, 95% CI 1.049–1.149, P 〈 0.001) were independent factors for a decrease in LAAFV. A novel score, LAD combined with CHA 2 DS 2 -VASc score, was more accurate for predicting a decrease in LAAFV among NVAF patients (area under the curve was 0.733). Conclusion Enlarged LAD was independent risk factor for a decrease in LAAFV among NVAF patients. LAD combined with CHA 2 DS 2 -VASc score enhanced the predictive ability for a decrease in LAAFV among NVAF patients.
Type of Medium:
Online Resource
ISSN:
1471-2261
DOI:
10.1186/s12872-022-03033-6
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2023
detail.hit.zdb_id:
2059859-2
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