In:
Neuropsychobiology, S. Karger AG, Vol. 82, No. 1 ( 2023), p. 24-32
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Observational studies highlight associations of common diseases with individual schizophrenia symptoms. However, it is unclear whether these diseases are associated with individual treatment-resistant schizophrenia (TRS). We aimed to explore the genetic associations between common immune diseases, metabolic diseases, psychiatric disorders, gut microbiota and TRS. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Genome-wide association study (GWAS) summary data of European participants ( 〈 i 〉 n 〈 /i 〉 = ∼456,327) included TRS, 11 psychiatric disorders, 23 immune and metabolic diseases, body mass index, height, and 211 gut microbiota. In this genetic correlation and two-sample Mendelian randomization (MR) study, linkage disequilibrium score (LDSC) regression was applied to infer genetic correlation estimates. Two-sample MR tested potential causal associations of genetic variants associated with common immune diseases, metabolic diseases, psychiatric disorders, and gut microbiota with TRS. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 LDSC revealed candidate associations between attention deficit/hyperactivity disorder (ADHD), schizophrenia, intestinal infectious diseases, obesity and TRS (genetic correlation range, 0.230–0.702; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.05). Two-sample MR analyses suggested that ADHD was positively associated with TRS (estimate [SE] = 0.204 [0.073] , 〈 i 〉 p 〈 /i 〉 = 0.005), a finding that remained stable across statistical models. Besides, schizophrenia and 〈 i 〉 genus Barnesiella 〈 /i 〉 levels were causally associated with TRS but not consistent across MR approaches. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 This study reports genetic correlations between ADHD, schizophrenia, intestinal infectious diseases, obesity and TRS. The study also found that 〈 i 〉 genus Barnesiella 〈 /i 〉 was associated with TRS. These findings may have clinical implications, highlighting the possible strategy for TRS prevention.
Type of Medium:
Online Resource
ISSN:
0302-282X
,
1423-0224
Language:
English
Publisher:
S. Karger AG
Publication Date:
2023
detail.hit.zdb_id:
1483094-2
SSG:
5,2
SSG:
15,3
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