In:
Journal of the chemical society of pakistan, Chemical Society of Pakistan, Vol. 43, No. 4 ( 2021), p. 466-466
Abstract:
News series of substituted quinazoline derivatives has been synthesized from 3,4-dihydro-7-methoxy-4-oxoquinazoline-6-yl acetate (1) by five-step procedures including chlorination, amination, hydrolysis and etherification. The structures of target compounds were confirmed by IR, 1H-NMR, element analysis and single-crystal X-ray diffraction. The results showed that the compound 8c exhibited remarkable inhibitory activity against MCF-7 cell lines with inhibition rate value of 38.45 %, which was comparable to that of the positive control Gefitinib (inhibition rate = 13.25 % for MCF-7). The initial relationship between structure and activity was worth further exploration.
Type of Medium:
Online Resource
ISSN:
0253-5106
Uniform Title:
Synthesis, Crystal Structure and Anticancer Activity of Substituted Quinazoline Derivatives
DOI:
10.52568/000583/JCSP/43.04.2021
Language:
Unknown
Publisher:
Chemical Society of Pakistan
Publication Date:
2021
detail.hit.zdb_id:
3024078-5
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