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  • 1
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Nutrition Vol. 9 ( 2022-10-27)
    In: Frontiers in Nutrition, Frontiers Media SA, Vol. 9 ( 2022-10-27)
    Abstract: Placental function is vital to the fetal growth of sows, and resveratrol (RES) can protect cells against oxidative stress, which is one of the major factors impairing placental function. This study aimed to investigate the effect of dietary resveratrol (RES) on placental function and reproductive performance during late pregnancy in a sow model from the aspects of oxidative stress, insulin resistance, and gut microbiota. A total of 26 hybrid pregnant sows (Landrace × Yorkshire) with similar parity were randomly allocated into two groups ( n = 13) and fed with a basal diet or a diet containing 200 mg/kg of resveratrol from day 85 of gestation until parturition. The dietary supplementation of RES increased the litter weight at parturition by 12.53% ( p = 0.145), with ameliorated insulin resistance (HOMA-IR), increased triglyceride (TG) levels, and decreased interleukin (IL)-1β and IL-6 levels in serum ( p & lt; 0.05). Moreover, resveratrol increased the placental vascular density ( p & lt; 0.05) with the enhanced expression of nutrient transporter genes ( SLC2A1 and SLC2A3 ) and antioxidant genes, such as superoxide dismutase 2 ( SOD2 ) and heme oxygenase-1 ( HO-1 ) but declined the expression of inflammatory genes, such as IL-1 β and IL-6 ( p & lt; 0.05). The characterization of the fecal microbiota revealed that resveratrol decreased the relative abundance of the Christensensllaceae R-7 group and Ruminococcaceae UCG-008 ( p & lt; 0.05), which had a positive linear correlation with the expression of IL-1 β and IL-6 ( p & lt; 0.05), but had a negative linear correlation with the expression of SOD2, HO-1, SLC2A1 , and SCL2A3 genes ( p & lt; 0.05). These data demonstrated that dietary supplementation with resveratrol can improve placental function with ameliorated insulin resistance, oxidative stress, and inflammation potentially by regulating Ruminococcaceae UCG-008 and the Christensensllaceae R-7 group in sows.
    Type of Medium: Online Resource
    ISSN: 2296-861X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2776676-7
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  • 2
    Online Resource
    Online Resource
    Elsevier BV ; 2011
    In:  Journal of Pharmaceutical and Biomedical Analysis Vol. 55, No. 2 ( 2011-5), p. 259-264
    In: Journal of Pharmaceutical and Biomedical Analysis, Elsevier BV, Vol. 55, No. 2 ( 2011-5), p. 259-264
    Type of Medium: Online Resource
    ISSN: 0731-7085
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2011
    detail.hit.zdb_id: 1491820-1
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Nutrition Vol. 9 ( 2022-6-3)
    In: Frontiers in Nutrition, Frontiers Media SA, Vol. 9 ( 2022-6-3)
    Abstract: This study aimed to evaluate the effect of an antibiotic cocktail on gut microbiota and provide a reference for establishing an available mouse model for fecal microbiota transplantation (FMT) of specific microbes. Design C57BL/6J mice ( n = 24) had free access to an antibiotic cocktail containing vancomycin (0.5 g/L), ampicillin (1 g/L), neomycin (1 g/L), and metronidazole (1 g/L) in drinking water for 3 weeks. Fecal microbiota was characterized by 16S rDNA gene sequencing at the beginning, 1st week, and 3rd week, respectively. The mice were then treated with fecal microbiota from normal mice for 1 week to verify the efficiency of FMT. Results The diversity of microbiota including chao1, observed species, phylogenetic diversity (PD) whole tree, and Shannon index were decreased significantly ( P & lt; 0.05) after being treated with the antibiotic cocktail for 1 or 3 weeks. The relative abundance of Bacteroidetes , Actinobacteria , and Verrucomicrobia was decreased by 99.94, 92.09, and 100%, respectively, while Firmicutes dominated the microbiota at the phylum level after 3 weeks of treatment. Meanwhile, Lactococcus , a genus belonging to the phylum of Firmicutes dominated the microbiota at the genus level with a relative abundance of 80.63%. Further FMT experiment indicated that the fecal microbiota from the receptor mice had a similar composition to the donor mice after 1 week. Conclusion The antibiotic cocktail containing vancomycin, ampicillin, neomycin, and metronidazole eliminates microbes belonging to Bacteroidetes , Actinobacteria , and Verrucomicrobia , which can be recovered by FMT in mice.
    Type of Medium: Online Resource
    ISSN: 2296-861X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2776676-7
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  • 4
    Online Resource
    Online Resource
    Informa UK Limited ; 2019
    In:  Infection and Drug Resistance Vol. Volume 12 ( 2019-07), p. 2283-2296
    In: Infection and Drug Resistance, Informa UK Limited, Vol. Volume 12 ( 2019-07), p. 2283-2296
    Type of Medium: Online Resource
    ISSN: 1178-6973
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2494856-1
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    MDPI AG ; 2018
    In:  Information Vol. 9, No. 12 ( 2018-12-07), p. 314-
    In: Information, MDPI AG, Vol. 9, No. 12 ( 2018-12-07), p. 314-
    Abstract: The binary discernibility matrix, originally introduced by Felix and Ushio, is a binary matrix representation for storing discernible attributes that can distinguish different objects in decision systems. It is an effective approach for feature selection, knowledge representation and uncertainty reasoning. An original binary discernibility matrix usually contains redundant objects and attributes. These redundant objects and attributes may deteriorate the performance of feature selection and knowledge acquisition. To overcome this shortcoming, row relations and column relations in a binary discernibility matrix are defined in this paper. To compare the relationships of different rows (columns) quickly, we construct deterministic finite automata for a binary discernibility matrix. On this basis, a quick algorithm for binary discernibility matrix simplification using deterministic finite automata (BDMSDFA) is proposed. We make a comparison of BDMR (an algorithm of binary discernibility matrix reduction), IBDMR (an improved algorithm of binary discernibility matrix reduction) and BDMSDFA. Finally, theoretical analyses and experimental results indicate that the algorithm of BDMSDFA is effective and efficient.
    Type of Medium: Online Resource
    ISSN: 2078-2489
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2599790-7
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  • 6
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 11 ( 2021-7-12)
    Abstract: Peripheral lymphatic radiotherapy in patients with pT3N0M0 and pT4N0M0 breast cancer has been a matter of considerable debate among radiation oncologists. This is the first report in a non-Caucasian population. Patients and Methods The study included 165 pT3N0M0 and pT4N0M0 patients. Univariate, multivariate, propensity score matching (PSM), and Kaplan-Meier analyses were conducted to evaluate the survival of patients. We also review all the literature about regional lymph nodes radiation in T3-4N0M0 patients and summarize them with tables to compare with the present study. Results The median follow-up duration was 58.7 months. Multivariate analyses showed that advance T stage and grade were dependent poor prognostic factors for OS, DMFS, LRFS, and DFS between group A (chest wall radiation) and group B (chest wall and regional lymph nodes radiation). The overall survival (OS), disease-free survival (DFS), local relapse-free survival (LRFS), and distant metastasis-free survival (DMFS) rates were not significantly different between group A and group B. The 5-year OS rate was 92.3% vs 89.7% for group A and group B, respectively (P=0.819). The 5-year LRFS rate was 94.9% vs 94.3% for group A and group B, respectively (P=0.852). Fifty-four pairs of patients were selected after propensity score matching (PSM) analysis was conducted. There was also no significant difference between group A and group B in regard to the OS, DFS, LRFS, and DMFS rates after PSM. The patients included in previous studies were all Caucasians, and our study was focused on non-Caucasians. The cases of previous studies were 10 to 20 years ago, but our study has more recent cases. The radiotherapy techniques of previous studies were conventional, and the techniques used in our study were three-dimensional conformal radiotherapy (3DCRT) or intensity modulated radiotherapy (IMRT). Conclusion Both our study and previous studies suggested that regional lymph nodes radiation cannot improve the survival rate for breast cancer patients with T3-4N0M0 in non-Caucasian population. Advance T stage and grade were the dependent poor prognostic factors for T3-4N0M0 patients.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2649216-7
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  • 7
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 12 ( 2021-11-24)
    Abstract: As the precursor of vitamin A, β-carotene has a positive effect on reproductive performance. Our previous study has shown that β-carotene can increase antioxidant enzyme activity potentially through regulating gut microbiota in pregnant sows. This study aimed to clarify the effect of β-carotene on reproductive performance and postpartum uterine recovery from the aspect of inflammation and gut microbiota by using a mouse model. Twenty-seven 6 weeks old female Kunming mice were randomly assigned into 3 groups (n=9), and fed with a diet containing 0, 30 or 90 mg/kg β-carotene, respectively. The results showed that dietary supplementation of β-carotene reduced postpartum uterine hyperemia and uterine mass index ( P & lt;0.05), improved intestinal villus height and villus height to crypt depth ratio, decreased serum TNF-α and IL-4 concentration ( P & lt;0.05), while no differences were observed in litter size and litter weight among three treatments. Characterization of gut microbiota revealed that β-carotene up-regulated the relative abundance of genera Akkermansia , Candidatus Stoquefichus and Faecalibaculum , but down-regulated the relative abundance of Alloprevotella and Helicobacter . Correlation analysis revealed that Akkermansia was negatively correlated with the IL-4 concentration, while Candidatus Stoquefichus and Faecalibaculum had a negative linear correlation with both TNF-α and IL-4 concentration. On the other hand, Alloprevotella was positively correlated with the TNF-α, and Helicobacter had a positive correlation with both TNF-α and IL-4 concentration. These data demonstrated that dietary supplementation of β-carotene contributes to postpartum uterine recovery by decreasing postpartum uterine hemorrhage and inhibiting the production of inflammatory cytokines potentially through modulating gut microbiota.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2606827-8
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  • 8
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Veterinary Science Vol. 9 ( 2022-7-28)
    In: Frontiers in Veterinary Science, Frontiers Media SA, Vol. 9 ( 2022-7-28)
    Abstract: Eucommia ulmoides bark has been traditionally used as a Chinese medicine to attenuate stress, but the leaf, which is rich in polyphenols and polysaccharides, has been rarely used. This study aimed to investigate the effect of Eucommia ulmoides leaf extracts (EULEs) on oxidative stress and meat quality of broilers. A total of 252 broilers were randomly divided into 3 treatments and fed with a control basal diet (CON), or a diet containing 250 mg/kg or 1,000 mg/kg of EULE for 51 days. Results showed that dietary supplementation of 250 mg/kg EULE increased significantly the average daily gain of broilers in the early stage (1–21 days), while 250 mg/kg or 1,000 mg/kg of EULE decreased the feed conversion ratio in the whole period ( P & lt; 0.05). Supplementation of 250 mg/kg EULE reduced the level of MDA in the liver ( P & lt; 0.05), while 1,000 mg/kg EULE decreased the serum level of MDA ( P & lt; 0.05), and the HDL level in serum was increased by 250 mg/kg or 1,000 mg/kg EULE ( P & lt; 0.05). Additionally, 250 mg/kg EULE decreased abdominal fat ratio and serum triglyceride (TC) level in broilers, while 250 or 1,000 mg/kg of EULE reduced drip loss in breast muscle ( P & lt; 0.05), and 1,000 mg/kg EULE reduced the cooking loss in thigh muscle ( P & lt; 0.05). In conclusion, dietary supplementation of 250 mg/kg of EULE could attenuate oxidative stress and improve the growth performance and meat quality in broilers.
    Type of Medium: Online Resource
    ISSN: 2297-1769
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2834243-4
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  • 9
    Online Resource
    Online Resource
    American Scientific Publishers ; 2013
    In:  Journal of Nanoscience and Nanotechnology Vol. 13, No. 1 ( 2013-01-01), p. 690-693
    In: Journal of Nanoscience and Nanotechnology, American Scientific Publishers, Vol. 13, No. 1 ( 2013-01-01), p. 690-693
    Type of Medium: Online Resource
    ISSN: 1533-4880 , 1533-4899
    Language: English
    Publisher: American Scientific Publishers
    Publication Date: 2013
    SSG: 11
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  • 10
    Online Resource
    Online Resource
    Elsevier BV ; 2012
    In:  Minerals Engineering Vol. 39 ( 2012-12), p. 23-28
    In: Minerals Engineering, Elsevier BV, Vol. 39 ( 2012-12), p. 23-28
    Type of Medium: Online Resource
    ISSN: 0892-6875
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2012
    detail.hit.zdb_id: 2015542-6
    SSG: 19,1
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