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  • 1
    Online Resource
    Online Resource
    World Congress Integrative Medicine & Health 2017: Part one : Berlin, Germany. 3-5 May 2017
    Springer Science and Business Media LLC ; 2017
    In:  BMC Complementary and Alternative Medicine Vol. 17, No. S1 ( 2017-6)
    Details
    In: BMC Complementary and Alternative Medicine, Springer Science and Business Media LLC, Vol. 17, No. S1 ( 2017-6)
    Type of Medium: Online Resource
    ISSN: 1472-6882
    URL: Article
    DOI: 10.1186/s12906-017-1782-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2050429-9
    detail.hit.zdb_id: 3037610-5
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  • 2
    Online Resource
    Online Resource
    Chinese herbal medicine for functional dyspepsia: a network meta-analysis of prokinetic-controlled randomised trials
    Springer Science and Business Media LLC ; 2021
    In:  Chinese Medicine Vol. 16, No. 1 ( 2021-12-20)
    Details
    In: Chinese Medicine, Springer Science and Business Media LLC, Vol. 16, No. 1 ( 2021-12-20)
    Abstract: Prokinetic is the first-line conventional treatment for functional dyspepsia (FD) in Asia despite potential adverse events. Chinese herbal medicine (CHM) may be an effective and safe substitution. This network meta-analysis (NMA) aimed to evaluate the comparative effectiveness of different CHM formulae for FD against prokinetics. Methods Seven international and Chinese databases were searched from their inception to July 2020 for randomised controlled trials (RCTs) on CHM versus prokinetics. Data from each RCT were first pooled using random-effect pairwise meta-analyses and illustrated as risk difference (RD) or standardised mean difference (SMD) with 95% confidence interval (CI). Random-effect NMAs were then performed to evaluate the comparative effectiveness of CHM formulae and displayed as RD with 95% CI or SMD with 95% credible interval (CrI). The GRADE partially contextualised framework was applied for NMA result interpretation. Results Twenty-six unique CHM formulae were identified from twenty-eight RCTs of mediocre quality. Pairwise meta-analyses indicated that CHM was superior to prokinetics in alleviating global symptoms at 4-week follow-up (pooled RD: 0.14; 95% CI: 0.10–0.19), even after trim and fill adjustment for publication bias. NMAs demonstrated that Modified Zhi Zhu Decoction may have a moderate beneficial effect on alleviating global symptoms at 4-week follow-up (RD: 0.28; 95% CI: − 0.03 to 0.75). Xiao Pi Kuan Wei Decoction may have a large beneficial effect on alleviating postprandial fullness (SMD: − 2.14; 95% CI: − 2.76 to 0.70), early satiety (SMD: − 3.90; 95% CI: − 0.68 to − 0.42), and epigastric pain (SMD: − 1.23; 95% CI: − 1.66 to − 0.29). No serious adverse events were reported. Conclusion Modified Zhi Zhu Decoction and Xiao Pi Kuan Wei Decoction may be considered as an alternative for patients unresponsive to prokinetics. Confirmatory head-to-head trials should be conducted to investigate their comparative effectiveness against prokinetics.
    Type of Medium: Online Resource
    ISSN: 1749-8546
    URL: Article
    DOI: 10.1186/s13020-021-00556-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2260322-0
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  • 3
    Online Resource
    Online Resource
    Development of Evidence-Based Chinese Medicine Clinical Service Recommendations for Cancer Palliative Care Using Delphi Approach Based on the Evidence to Decision Framework
    SAGE Publications ; 2020
    In:  Integrative Cancer Therapies Vol. 19 ( 2020-01), p. 153473542094041-
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 19 ( 2020-01), p. 153473542094041-
    Abstract: Objectives: Existing evidence supports the use of certain Chinese medicine (CM) interventions for symptom management among palliative cancer patients. However, evidence-based service recommendations tailored to the local context are needed for CM planning and implementation. In response, we aimed to establish consensus on CM clinical service recommendations for cancer palliative care among Hong Kong experts. Methods: Seven CM interventions showing statistically significant favorable results in existing systematic reviews (SRs) and overviews of SRs were subjected to a GRADE-ADOLOPMENT–based 2-round Delphi survey. Twelve Hong Kong experts in cancer palliative care, including conventionally trained physicians, CM practitioners, and nurses (n = 4 from each category), were invited to participate. Use of the Evidence to Decision framework within the GRADE-ADOLOPMENT approach enabled experts to consider aspects of problem priority, benefits, harms, equity, acceptability, and feasibility when making CM recommendations in cancer palliative care. Results: Three evidence-based CM interventions reached positive consensus as service recommendations, namely: (1) acupuncture for reducing fatigue among palliative cancer patients; (2) acupressure for reducing fatigue among palliative cancer patients; and (3) moxibustion for reducing nausea and vomiting among patients receiving chemotherapy. Median rating of recommendation ranged from 2.5 to 3.0 (interquartile range = 0.00-1.00) on a 4-point Likert-type scale, and the percentage agreement ranged from 83.4% to 91.7%. Conclusions: The GRADE-ADOLOPMENT approach facilitates a consensus-based process of reaching 3 evidence-based CM recommendations for cancer palliative care. Future studies may develop tailored strategies to implement these recommendations in the Hong Kong health system.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/1534735420940418
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2101248-9
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  • 4
    Online Resource
    Online Resource
    Electroacupuncture plus standard of care for managing refractory functional dyspepsia: protocol of a pragmatic trial with economic evaluation
    BMJ ; 2018
    In:  BMJ Open Vol. 8, No. 3 ( 2018-03), p. e018430-
    Details
    In: BMJ Open, BMJ, Vol. 8, No. 3 ( 2018-03), p. e018430-
    Abstract: This trial proposes to compare the effectiveness and cost-effectiveness of electroacupuncture (EA) plus on-demand gastrocaine with waiting list for EA plus on-demand gastrocaine in providing symptom relief and quality-of-life improvement among patients with functional dyspepsia (FD). Methods and analysis This is a single-centre, pragmatic, randomised parallel-group, superiority trial comparing the outcomes of (1) EA plus on-demand gastrocaine group and (2) waiting list to EA plus on-demand gastrocaine group. 132 (66/arm) endoscopically confirmed, Helicobacter pylori -negative patients with FD will be recruited. Enrolled patients will respectively be receiving (1) 20 sessions of EA over 10 weeks plus on-demand gastrocaine; or (2) on-demand gastrocaine and being nominated on to a waiting list for EA, which entitles them 20 sessions of EA over 10 weeks after 12 weeks of waiting. The primary outcome will be the between-group difference in proportion of patients achieving adequate relief of symptoms over 12 weeks. The secondary outcomes will include patient-reported change in global symptoms and individual symptoms, Nepean Dyspepsia Index, Nutrient Drink Test, 9-item Patient Health Questionnaire (PHQ9), and 7-item Generalised Anxiety Disorder Scale (GAD7). Adverse events will be assessed formally. Results on direct medical costs and on the EuroQol (EQ-5D) questionnaire will also be used to assess cost-effectiveness. Analysis will follow the intention-to-treat principle using appropriate univariate and multivariate methods. A mixed model analysis taking into account missing data of these outcomes will be performed. Cost-effectiveness analysis will be performed using established approach. Ethics and dissemination The study is supported by the Health and Medical Research Fund, Government of the Hong Kong Special Administrative Region of China. It has been approved by the Joint Chinese University of Hong Kong – New Territories East Cluster Clinical Research Ethics Committee. Results will be published in peer-reviewed journals and be disseminated in international conference. Trial registration number ChiCTR-IPC-15007109; Pre-result.
    Type of Medium: Online Resource
    ISSN: 2044-6055 , 2044-6055
    URL: Article
    DOI: 10.1136/bmjopen-2017-018430
    Language: English
    Publisher: BMJ
    Publication Date: 2018
    detail.hit.zdb_id: 2599832-8
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  • 5
    Online Resource
    Online Resource
    Comparing diagnostic performance of Cantonese-Chinese version of Rome IV criteria and a short Reference Standard for functional dyspepsia in China
    Springer Science and Business Media LLC ; 2022
    In:  BMC Gastroenterology Vol. 22, No. 1 ( 2022-10-12)
    Details
    In: BMC Gastroenterology, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-10-12)
    Abstract: Functional dyspepsia (FD) is diagnosed based on self-reported symptoms and negative upper gastrointestinal endoscopic findings. The Rome criteria were not adopted as a diagnostic instrument in clinical guidelines due to their complexity. Different guidelines used relatively simple symptom assessment schemes with contents that vary significantly. A previously evaluated short Reference Standard may serve as a more standardised tool for guidelines. We evaluated its diagnostic accuracy against the Rome IV criteria in a cross-sectional study in Hong Kong. Methods A total of 220 dyspeptic patients sampled consecutively from a tertiary hospital and the community completed the Rome IV diagnostic questionnaire, which was translated into Cantonese-Chinese, and the Reference Standard. Sensitivity, specificity, positive and negative likelihood ratios (LRs), and area under the receiver operating characteristics curve (AUC), with 95% confidence intervals (CIs), were calculated. Results Among the participants, 160 (72.7%) fulfilled the Reference Standard with negative upper gastrointestinal endoscopic results. The Reference Standard identified patients with Rome IV-defined FD with 91.1% (95% CI 82.6%–96.4%) sensitivity and 37.6% (95% CI 29.6%–46.1%) specificity. The positive and negative LRs were 1.46 (95% CI 1.26–1.69) and 0.24 (95% CI 0.11–0.49), respectively. The AUC value was 0.64 (95% CI 0.59–0.69). Conclusions The Reference Standard can rule out patients without Rome IV-defined FD. It may be used as an initial screening tool for FD in settings where the use of the Rome IV criteria is impractical. It may also provide a uniform definition and diagnostic rule for future updates of clinical guidelines.
    Type of Medium: Online Resource
    ISSN: 1471-230X
    URL: Article
    DOI: 10.1186/s12876-022-02520-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041351-8
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  • 6
    Online Resource
    Online Resource
    Prioritizing Chinese medicine clinical research questions in cancer palliative care from patient and caregiver perspectives
    Wiley ; 2021
    In:  Health Expectations Vol. 24, No. 4 ( 2021-08), p. 1487-1497
    Details
    In: Health Expectations, Wiley, Vol. 24, No. 4 ( 2021-08), p. 1487-1497
    Abstract: Chinese medicine (CM) modalities, including acupuncture and Chinese herbal medicine (CHM), are popular palliative interventions among patients with cancer, but further clinical research is required to assess their effectiveness and safety. Objective To prioritize top ten important CM clinical research questions from patients with cancer, cancer survivors and caregivers’ perspectives via a face‐to‐face prioritization workshop in Hong Kong. Methods A list of 25 CM clinical research questions for cancer palliative care, which were identified from existing systematic reviews (SRs) and overview of SRs, was presented to 17 participants (patients with cancer [n = 5], cancer survivors [n = 6] and caregivers [n = 6]). The participants were then invited to establish consensus on prioritizing top ten research questions. Results Among the top ten priorities, five (50%) focused on acupuncture and related therapies, while five (50%) were on CHM. The three most important research priorities were (i) manual acupuncture plus opioids for relieving pain; (ii) CHM for improving quality of life among patients receiving chemotherapy; and (iii) concurrent use of CHM plus loperamide for reducing stomatitis. Conclusion The top ten participant‐endorsed CM clinical research priorities for cancer palliative care can guide local researchers on future direction. They can also inform local research funders on patient‐centred allocation of limited funding. Under limited research funding, the most important co‐prioritized research question from professional and patient perspectives may be addressed first. Patient or Public Contribution Patients with cancer, cancer survivors and caregivers participated in conduct of the study to prioritize CM clinical research questions.
    Type of Medium: Online Resource
    ISSN: 1369-6513 , 1369-7625
    URL: Issue
    URL: Article
    DOI: 10.1111/hex.v24.4
    DOI: 10.1111/hex.13289
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2006357-X
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  • 7
    Online Resource
    Online Resource
    Designing delivery models of traditional and complementary medicine services: a review of international experiences
    Oxford University Press (OUP) ; 2021
    In:  British Medical Bulletin Vol. 137, No. 1 ( 2021-03-25), p. 70-81
    Details
    In: British Medical Bulletin, Oxford University Press (OUP), Vol. 137, No. 1 ( 2021-03-25), p. 70-81
    Abstract: The World Health Organization advocates integration of traditional and complementary medicine (T & CM) into the conventional health services delivery system. Integrating quality services in a patient-centred manner faces substantial challenges when T & CM is delivered within a health system dominated by conventional medicine. This review has synthesized international experiences of integration strategies across different contexts. Sources of data Publications describing international experiences of delivering T & CM service in conventional healthcare settings were searched. Backward and forward citation chasing was also conducted. Areas of agreement Capable leaders are crucial in seeking endorsement from stakeholders within the conventional medicine hierarchy and regulatory bodies. However, patient demands for integrative care can be successful as demonstrated by cases included in this review, as can the promotion of the use of T & CM for filling effectiveness gaps in conventional medicine. Safeguarding quality and safety of the services is a priority. Areas of controversy Different referral mechanisms between conventional and T & CM practitioners suit different contexts, but at a minimum, general guideline on responsibilities across the two professionals is required. Evidence-based condition-specific referral protocols with detailed integrative treatment planning are gaining in popularity. Growing points Interprofessional education is critical to establishing mutual trust and understanding between conventional clinicians and T & CM practitioners. Interprofessional communication is key to a successful collaboration, which can be strengthened by patient chart sharing, instant information exchange, and dedicated time for face-to-face interactions. Areas timely for developing research Research is needed on the optimal methods for financing integrated care to ensure equitable access, as well as in remuneration of T & CM practitioners working in integrative healthcare.
    Type of Medium: Online Resource
    ISSN: 0007-1420 , 1471-8391
    URL: Article
    DOI: 10.1093/bmb/ldaa046
    RVK:
    WA 15000
    RVK:
    YG 6900
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 1494704-3
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  • 8
    Online Resource
    Online Resource
    Learning-Based Reconstruction of FRI Signals
    Institute of Electrical and Electronics Engineers (IEEE) ; 2023
    In:  IEEE Transactions on Signal Processing Vol. 71 ( 2023), p. 2564-2578
    Details
    In: IEEE Transactions on Signal Processing, Institute of Electrical and Electronics Engineers (IEEE), Vol. 71 ( 2023), p. 2564-2578
    Type of Medium: Online Resource
    ISSN: 1053-587X , 1941-0476
    URL: Article
    DOI: 10.1109/TSP.2023.3290355
    RVK:
    SA 5530
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2023
    detail.hit.zdb_id: 2034304-8
    detail.hit.zdb_id: 187297-7
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  • 9
    Online Resource
    Online Resource
    Neural heterogeneity promotes robust learning
    Springer Science and Business Media LLC ; 2021
    In:  Nature Communications Vol. 12, No. 1 ( 2021-10-04)
    Details
    In: Nature Communications, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2021-10-04)
    Abstract: The brain is a hugely diverse, heterogeneous structure. Whether or not heterogeneity at the neural level plays a functional role remains unclear, and has been relatively little explored in models which are often highly homogeneous. We compared the performance of spiking neural networks trained to carry out tasks of real-world difficulty, with varying degrees of heterogeneity, and found that heterogeneity substantially improved task performance. Learning with heterogeneity was more stable and robust, particularly for tasks with a rich temporal structure. In addition, the distribution of neuronal parameters in the trained networks is similar to those observed experimentally. We suggest that the heterogeneity observed in the brain may be more than just the byproduct of noisy processes, but rather may serve an active and important role in allowing animals to learn in changing environments.
    Type of Medium: Online Resource
    ISSN: 2041-1723
    URL: Article
    DOI: 10.1038/s41467-021-26022-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2553671-0
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  • 10
    Online Resource
    Online Resource
    First-spike coding promotes accurate and efficient spiking neural networks for discrete events with rich temporal structures
    Frontiers Media SA ; 2023
    In:  Frontiers in Neuroscience Vol. 17 ( 2023-10-2)
    Details
    In: Frontiers in Neuroscience, Frontiers Media SA, Vol. 17 ( 2023-10-2)
    Abstract: Spiking neural networks (SNNs) are well-suited to process asynchronous event-based data. Most of the existing SNNs use rate-coding schemes that focus on firing rate (FR), and so they generally ignore the spike timing in events. On the contrary, methods based on temporal coding, particularly time-to-first-spike (TTFS) coding, can be accurate and efficient but they are difficult to train. Currently, there is limited research on applying TTFS coding to real events, since traditional TTFS-based methods impose one-spike constraint, which is not realistic for event-based data. In this study, we present a novel decision-making strategy based on first-spike (FS) coding that encodes FS timings of the output neurons to investigate the role of the first-spike timing in classifying real-world event sequences with complex temporal structures. To achieve FS coding, we propose a novel surrogate gradient learning method for discrete spike trains. In the forward pass, output spikes are encoded into discrete times to generate FS times. In the backpropagation, we develop an error assignment method that propagates error from FS times to spikes through a Gaussian window, and then supervised learning for spikes is implemented through a surrogate gradient approach. Additional strategies are introduced to facilitate the training of FS timings, such as adding empty sequences and employing different parameters for different layers. We make a comprehensive comparison between FS and FR coding in the experiments. Our results show that FS coding achieves comparable accuracy to FR coding while leading to superior energy efficiency and distinct neuronal dynamics on data sequences with very rich temporal structures. Additionally, a longer time delay in the first spike leads to higher accuracy, indicating important information is encoded in the timing of the first spike.
    Type of Medium: Online Resource
    ISSN: 1662-453X
    URL: Article
    DOI: 10.3389/fnins.2023.1266003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2411902-7
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