In:
DICP, SAGE Publications, Vol. 24, No. 5 ( 1990-05), p. 456-460
Abstract:
The use of positron emission tomography (PET) has been well documented as a relatively noninvasive method of measuring cerebral blood flow (CBF), both globally and regionally. The utility of readily detecting alterations in CBF is apparent, particularly when applied to the evaluation of therapeutic interventions thought to influence CBF. We report the effects of hypocapnia, an experimental condition of known cerebral vasoconstriction, in ten normal volunteers. Subjects had brain blood flow evaluated utilizing H 2 15 O as the positron emitter before and after approximately five minutes of hyperventilation. Baseline CBF was measured as a mean ± SD of 61.2 ± 16.3 mL/min/100 g of tissue. Mean baseline arterial blood gas values were PaO 2 107.4 ± 14 mm Hg, PaCO 2 37.7 ± 0.89 mm Hg, and pH 7.39 (calculated from mean [H + ]). Post hyperventilation, global CBF was measured as 31.1 ± 10.8 mL/min/100 g. Mean arterial blood gas values were PaO 2 141.7 ± 21 mm Hg, PaCO 2 19.7 ± 5 mm Hg, and pH 7.63 (calculated from mean [H + ]). CBF decreased by a mean of 49.5 ± 11 percent. Data analysis using the Student's t-est showed a significant change over baseline in PaCO 2 (p 〈 0.001) and CBF (p 〈 0.001), in the hyperventilated state. Correlations were noted between the decrease in CBF and change in PaCO 2 (r = 0.81) as well as between hyperventilation PaCO 2 and the change in CBF (r=0.97). We conclude that, as measured by PET, CBF decreases significantly during a state of artificial hyperventilation to a degree consistent with results seen using other methods. PET appears to be a valuable tool in the assessment of interventions that could influence CBF.
Type of Medium:
Online Resource
ISSN:
1042-9611
DOI:
10.1177/106002809002400501
Language:
English
Publisher:
SAGE Publications
Publication Date:
1990
detail.hit.zdb_id:
2053518-1
SSG:
15,3
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