In:
Public Health Nutrition, Cambridge University Press (CUP), Vol. 11, No. 9 ( 2008-09), p. 955-962
Abstract:
A substantial fall in high-density lipoprotein cholesterol (HDL-C) during puberty in boys, but not girls, has been reported in Western populations. The fall in boys is believed to be due to hormonal changes – androgens have been shown to be associated with lower HDL-C, whereas oestrogens are associated with higher HDL-C. The fall in HDL-C during puberty was not observed, however, in a study of Moslem boys in Israel, nor in a group of Japanese boys. A diet high in phyto-oestrogens may account for the lack of a fall in HDL-C in these populations. Objective To examine the effect of dietary supplementation with phyto-oestrogens on the HDL-C concentration of adolescent boys from a Western population. We hypothesised that dietary supplementation of 50 mg of the isoflavones daidzein and genistein would produce a 12% higher HDL-C concentration than in controls at the end of a 6-week intervention period. Design A randomised controlled trial. Setting Hellyer College in Burnie (Tasmania, Australia). Subjects Adolescent boys (aged 16–18 years) were recruited through a letter sent to parents. A total of 132 eligible participants enrolled and five subjects withdrew from the trial. Results No significant increase in HDL-C was observed in the treatment group (–0.02 mmol l –1 , standard error (SE)=0.03, P = 0.53) or the placebo group (0.05 mmol l –1 , SE = 0.03, P = 0.11). Conclusions Factors other than isolated dietary isoflavones may be responsible for the lack of fall in HDL-C during puberty in Japanese and Moslem boys.
Type of Medium:
Online Resource
ISSN:
1368-9800
,
1475-2727
DOI:
10.1017/S1368980007000869
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
2008
detail.hit.zdb_id:
2016337-X
SSG:
21
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