In:
Molecular Oncology, Wiley, Vol. 9, No. 2 ( 2015-02), p. 398-408
Abstract:
We develop HER2 antibody, 1E11 synergistic with trastuzumab in gastric cancers. 1E11 and trastuzumab (TRA) bind to sub‐domain IV having non‐overlapping epitopes. 1E11 + TRA induce strong apoptosis compared to pertuzumab (PER) + TRA. 1E11 + TRA and PER + TRA reduce HER2 protein and down steam signaling. 1E11 + TRA shows superior antitumor activity to PER + TRA in xenograft models.
Type of Medium:
Online Resource
ISSN:
1574-7891
,
1878-0261
DOI:
10.1016/j.molonc.2014.09.007
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2322586-5
Permalink