In:
Head & Neck, Wiley, Vol. 38, No. 1 ( 2016-01), p. 66-71
Abstract:
The purpose of this study was to determine if hyperinsulinemia and/or insulin resistance are/is associated with the prevalence of papillary thyroid cancer (PTC) in Korean women. Methods This study included 735 female patients with PTC and 537 female non‐PTC control subjects. Multiple logistic regression analysis was performed to evaluate the associations between hyperinsulinemia/insulin resistance and the occurrence of PTC. Results The prevalence of PTC was significantly correlated with increased insulin, glucose levels, and a high homeostasis model of assessment‐insulin resistance (HOMA‐IR). The multivariate adjusted odds ratios for the prevalence of PTC in the highest quartile groups for insulin, glucose, and HOMA‐IR were 2.88, 9.32, and 4.07 (all p 〈 .001), respectively, compared with the lowest quartile groups. Pathological analyses revealed that increased serum glucose, insulin levels, and a higher HOMA‐IR were associated with the multifocality of PTC. Conclusion Hyperinsulinemia and/or insulin resistance may be associated with the development of PTC, but not disease severity in Korean women. © 2015 Wiley Periodicals, Inc. Head Neck 38: 66–71, 2016
Type of Medium:
Online Resource
ISSN:
1043-3074
,
1097-0347
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2001440-5
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