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  • 1
    Online Resource
    Online Resource
    Potential enhancement of host immunity and anti-tumor efficacy of nanoscale curcumin and resveratrol in colorectal cancers by modulated electro- hyperthermia
    Springer Science and Business Media LLC ; 2020
    In:  BMC Cancer Vol. 20, No. 1 ( 2020-12)
    Details
    In: BMC Cancer, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Abstract: Modulated electro-hyperthermia (mEHT) is a form of hyperthermia used in cancer treatment. mEHT has demonstrated the ability to activate host immunity by inducing the release of heat shock proteins, triggering apoptosis, and destroying the integrity of cell membranes to enhance cellular uptake of chemo-drugs in tumor cells. Both curcumin and resveratrol are phytochemicals that function as effective antioxidants, immune activators, and potential inhibitors of tumor development. However, poor bioavailability is a major obstacle for use in clinical cancer treatment. Methods This purpose of this study was to investigate whether mEHT can increase anti-cancer efficacy of nanosized curcumin and resveratrol in in vitro and in vivo models. The in vitro study included cell proliferation assay, cell cycle, and apoptosis analysis. Serum concentration was analyzed for the absorption of curcumin and resveratrol in SD rat model. The in vivo CT26/BALB/c animal tumor model was used for validating the safety, tumor growth curve, and immune cell infiltration within tumor tissues after combined mEHT/curcumin/resveratrol treatment. Results The results indicate co-treatment of mEHT with nano-curcumin and resveratrol significantly induced cell cycle arrest and apoptosis of CT26 cells. The serum concentrations of curcumin and resveratrol were significantly elevated when mEHT was applied. The combination also inhibited the growth of CT26 colon cancer by inducing apoptosis and HSP70 expression of tumor cells while recruiting CD3+ T-cells and F4/80+ macrophages. Conclusions The results of this study have suggested that this natural, non-toxic compound can be an effective anti-tumor strategy for clinical cancer therapy. mEHT can enable cellular uptake of potential anti-tumor materials and create a favorable tumor microenvironment for an immunological chain reaction that improves the success of combined treatments of curcumin and resveratrol.
    Type of Medium: Online Resource
    ISSN: 1471-2407
    URL: Article
    DOI: 10.1186/s12885-020-07072-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2041352-X
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  • 2
    Online Resource
    Online Resource
    Association between weight change during initial chemotherapy and clinical outcome in dogs with multicentric lymphoma
    Wiley ; 2021
    In:  Veterinary and Comparative Oncology Vol. 19, No. 1 ( 2021-03), p. 53-60
    Details
    In: Veterinary and Comparative Oncology, Wiley, Vol. 19, No. 1 ( 2021-03), p. 53-60
    Abstract: The majority of the known prognostic factors in dogs with lymphoma have been evaluated before treatment commences or at the time of diagnosis. Prognostic factors evaluated during the initial phase of treatment are less described but may provide important clinical information. In this retrospective study, 82 canine lymphoma patients were categorized according to the weight change between diagnosis and after 5 weeks of chemotherapy. Dogs that gained greater than 5% or lost greater than 5% of initial body weight were categorized as increased‐ or decreased‐weight groups, respectively. Those in which weight changed less than 5% were categorized as the maintained‐weight group. The median progression‐free survival (PFS) in the increased‐weight group, maintained‐weight group and decreased‐weight group was 226, 256 and 129 days, respectively. The decreased‐weight group had significantly shorter PFS than the increased and maintained groups ( P = .023, P = .003, respectively). The median survival time (ST) in the increased‐weight group, maintained‐weight group and decreased‐weight group was 320, 339 and 222 days, respectively. There was no significant difference in ST among the three groups ( P = .128). In Cox‐regression results, weight change group and initial body weight were significant risk factors associated to PFS ( P = .007, P = .001, respectively) while only patient's initial body weight was a significant risk factor to ST ( P = .013). In conclusion, evaluation of initial body weight and weight changes over time can provide valuable information regarding PFS and ST in dogs with multicentric lymphoma.
    Type of Medium: Online Resource
    ISSN: 1476-5810 , 1476-5829
    URL: Issue
    URL: Article
    DOI: 10.1111/vco.v19.1
    DOI: 10.1111/vco.12637
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2129634-0
    SSG: 22
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  • 3
    Online Resource
    Online Resource
    Suppressive function of low‐dose deguelin on the invasion of oral cancer cells by downregulating tumor necrosis factor alpha–induced nuclear factor‐kappa B signaling
    Wiley ; 2016
    In:  Head & Neck Vol. 38, No. S1 ( 2016-04)
    Details
    In: Head & Neck, Wiley, Vol. 38, No. S1 ( 2016-04)
    Abstract: Deguelin has both antiproliferation and antimetastasis activities. However, high‐dose deguelin elicits many undesired side effects. The purpose of this study was to investigate whether the low‐dose deguelin can prevent the metastasis of oral cancer. Methods The dose effects of deguelin on metastasis of oral cancer cells were analyzed by in vitro invasion assay and an orthotropic xenograft mouse model. The involvement of tumor necrosis factor alpha (TNF‐α)‐induced nuclear factor‐kappa B (NF‐κB) signaling was examined by Western blot and reporter assay. Results Low‐dose deguelin, which has minimal cytotoxicity, significantly inhibited the invasion and migration of oral cancer cells. These inhibitory effects of low‐dose deguelin were mediated by suppressing TNF‐α‐induced activation of IκB kinase leading to the inhibition of IκB phosphorylation, NF‐κB transcriptional activity, and matrix metalloproteinase‐2 (MMP2) expression. The low‐dose deguelin treatment significantly inhibited tumor growth and invasion without systemic toxicity. Conclusion The low‐dose deguelin suppressed the invasion and migration of oral cancer by downregulating TNF‐α‐induced NF‐κB signaling. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E524–E534, 2016
    Type of Medium: Online Resource
    ISSN: 1043-3074 , 1097-0347
    URL: Issue
    URL: Article
    DOI: 10.1002/hed.v38.S1
    DOI: 10.1002/hed.24034
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2001440-5
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  • 4
    Online Resource
    Online Resource
    Comparison of plasma-lyte A and trometamol-balanced priming solutions for cardiopulmonary bypass in a swine model: a pilot study
    Office of Academic Resources, Chulalongkorn University - DIGITAL COMMONS JOURNALS ; 2020
    In:  The Thai Journal of Veterinary Medicine Vol. 50, No. 1 ( 2020-03-01), p. 33-42
    Details
    In: The Thai Journal of Veterinary Medicine, Office of Academic Resources, Chulalongkorn University - DIGITAL COMMONS JOURNALS, Vol. 50, No. 1 ( 2020-03-01), p. 33-42
    Type of Medium: Online Resource
    ISSN: 2985-1130
    URL: Article
    DOI: 10.56808/2985-1130.3073
    Language: English
    Publisher: Office of Academic Resources, Chulalongkorn University - DIGITAL COMMONS JOURNALS
    Publication Date: 2020
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  • 5
    Online Resource
    Online Resource
    Genome-wide DNA methylation analysis using MethylCap-seq in canine high-grade B-cell lymphoma
    Oxford University Press (OUP) ; 2021
    In:  Journal of Leukocyte Biology Vol. 109, No. 6 ( 2021-06-01), p. 1089-1103
    Details
    In: Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 109, No. 6 ( 2021-06-01), p. 1089-1103
    Abstract: DNA methylation is a comprehensively studied epigenetic modification and plays crucial roles in cancer development. In the present study, MethylCap-seq was used to characterize the genome-wide DNA methylation patterns in canine high-grade B-cell lymphoma (cHGBL). Canine methylated DNA fragments were captured and the MEDIUM-HIGH and LOW fraction of methylated DNA was obtained based on variation in CpG methylation density. In the MEDIUM-HIGH and LOW fraction, 2144 and 1987 cHGBL-specific hypermethylated genes, respectively, were identified. Functional analysis highlighted pathways strongly related to oncogenesis. The relevant signaling pathways associated with neuronal system were also revealed, echoing recent novel findings that neurogenesis plays key roles in tumor establishment. In addition, 14 genes were hypermethylated in all the cHGBL cases but not in the healthy dogs. These genes might be potential signatures for tracing cHGBL, and some of them have been reported to play roles in various types of cancers. Further, the distinct methylation pattern of cHGBL showed a concordance with the clinical outcome, suggesting that aberrant epigenetic changes may influence tumor behavior. In summary, our study characterized genome-wide DNA methylation patterns using MethylCap-seq in cHGBL; the findings suggest that specific DNA hypermethylation holds promise for dissecting tumorigenesis and uncovering biomarkers for monitoring the progression of cHGBL.
    Type of Medium: Online Resource
    ISSN: 0741-5400 , 1938-3673
    URL: Article
    DOI: 10.1002/JLB.2A0820-673R
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2026833-6
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    COMPARISON OF CYTOLOGICAL AND HISTOPATHOLOGICAL VALIDATION ON FINE NEEDLE ASPIRATION OF SUPERFICIAL MASSES
    World Scientific Pub Co Pte Ltd ; 2014
    In:  Taiwan Veterinary Journal Vol. 40, No. 04 ( 2014-12), p. 191-198
    Details
    In: Taiwan Veterinary Journal, World Scientific Pub Co Pte Ltd, Vol. 40, No. 04 ( 2014-12), p. 191-198
    Abstract: In this study, we compared the accuracy of using cytological and histopathological methods to diagnose superficial masses, examining the discrepancies between these methods to clarify the clinical usefulness of cytology. Complete agreement (CA) was demonstrated in 62.62% of the masses, partial agreement (PA) in 15.10% of the masses, and disagreement (DA) in 22.28% of the masses. The accuracy in identifying cell origin was 70.05%. When diagnosing neoplasia, cytology exhibited 68.62% sensitivity and 77.22% specificity; its positive predictive value was 92.53% and negative predictive value was 37.42%. The overall agreement in diagnosing malignancy was 70.3%. We accurately diagnosed certain neoplasms based on specific cytological characteristics. Even when handling uncertain samples, cytological examination yielded high sensitivity and positive predictive values for diagnosing malignancy; this should be sufficient for veterinary clinicians to schedule further treatments.
    Type of Medium: Online Resource
    ISSN: 1682-6485 , 2382-5588
    URL: Article
    DOI: 10.1142/S168264851450022X
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2014
    SSG: 22
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  • 7
    Online Resource
    Online Resource
    Granulysin expressed in a humanized mouse model induces apoptotic cell death and suppresses tumorigenicity
    Impact Journals, LLC ; 2017
    In:  Oncotarget Vol. 8, No. 48 ( 2017-10-13), p. 83495-83508
    Details
    In: Oncotarget, Impact Journals, LLC, Vol. 8, No. 48 ( 2017-10-13), p. 83495-83508
    Type of Medium: Online Resource
    ISSN: 1949-2553
    URL: Issue
    URL: Article
    DOI: 10.18632/oncotarget.v8i48
    DOI: 10.18632/oncotarget.11473
    Language: English
    Publisher: Impact Journals, LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2560162-3
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  • 8
    Online Resource
    Online Resource
    Effect of the VP3 gene of chicken anemia virus on canine mammary tumor cells
    American Veterinary Medical Association (AVMA) ; 2007
    In:  American Journal of Veterinary Research Vol. 68, No. 4 ( 2007-04), p. 411-422
    Details
    In: American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 68, No. 4 ( 2007-04), p. 411-422
    Abstract: Objective —To investigate the antitumor effect of the chicken anemia virus (CAV) VP3 gene in canine mammary tumor (CMT) cells. Sample Populations —Established primary canine cell lines that originated from epithelial cells of resected CMTs and nonneoplastic mammary gland epithelial (MGE) cells. Procedures —Expression vectors and lentiviral vectors encoding the VP3 gene from a Taiwan-Ilan isolate of CAV were used to deliver the VP3 gene into CMT cells and nonneoplastic MGE cells. Ectopic gene expression and the pro-apoptotic effect of the VP3 gene on CMT and nonneoplastic MGE cells by either transfection or viral infection were evaluated via immunofluorescence microscopy, western blot analysis, and terminal deoxynucleotidyl transferase–mediated dUTP nick-end labeling analysis. Results —Overexpression of the enhanced green fluorescent protein–VP3 fusion protein was detected predominantly in the nuclei of CMT cells. In contrast, the VP3 protein was localized to the cytoplasm of nonneoplastic MGE cells. Among the fusion protein–expressing CMT cells, most underwent characteristic changes of apoptosis, whereas apoptosis was not detected in fusion protein–expressing, nonneoplastic MGE cells. Induction of apoptosis by VP3 gene overexpression in CMT cells was associated with the caspase-9–, but not the caspase-8–, mediated apoptosis pathway. Conclusions and Clinical Relevance —These data indicate that the VP3 gene of the CAV induces apoptosis in malignant CMT cells, but not in nonneoplastic canine MGE cells. On the basis of such tumor cell–specific killing, the VP3 gene may be a promising agent for the treatment of malignant mammary gland tumors in dogs.
    Type of Medium: Online Resource
    ISSN: 0002-9645
    URL: Article
    DOI: 10.2460/ajvr.68.4.411
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2007
    detail.hit.zdb_id: 2056942-7
    SSG: 22
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  • 9
    Online Resource
    Online Resource
    Simultaneous visual inspection for barometric whole-body plethysmography waveforms during pulmonary function testing in client-owned cats
    SAGE Publications ; 2016
    In:  Journal of Feline Medicine and Surgery Vol. 18, No. 10 ( 2016-10), p. 761-767
    Details
    In: Journal of Feline Medicine and Surgery, SAGE Publications, Vol. 18, No. 10 ( 2016-10), p. 761-767
    Abstract: For the purpose of applying a barometric whole-body plethysmography (BWBP) device as a routine clinical tool in client-owned cats, the objective of this study was to evaluate the methodological importance of simultaneous visual inspection (SVI) of graphic tracing. Methods To investigate the effect of SVI on the results obtained, 50 client-owned cats were included. Breath-by-breath analysis was conducted with BWBP software, and a commonly used rejection setting was chosen for automatic elimination (AE) of non-breath artefactual waveforms, according to tidal volume (TV), inspiratory and expiratory time, and the difference between inspiratory and expiratory volumes. During 10 mins of data recording, SVI for BWBP waveforms was performed to record manually time periods that were free of any artefacts. The two datasets derived from AE alone (AEA method) and AE plus SVI (SVI-AE method) were compared. The inter-observer effect on the process of SVI was evaluated on six cats. Results There were statistically significant differences ( P 〈 0.001) between the AEA and SVI-AE datasets for most BWBP parameters. Bland–Altman analysis of the parameter-enhanced pause (Penh) showed heterogeneous variances, indicating less agreement when the Penh values were large. Intra-individual coefficients of variation of Penh were significantly higher with the AEA method than with the SVI-AE method (61.1% vs 34.7%, respectively; P 〈 0.001). Inter-observer agreement on the SVI process was excellent, and no statistically significant differences between the two observers were found for any BWBP parameters obtained by the SVI-AE method ( P 〉 0.05). Conclusions and relevance Visual inspection for BWBP waveforms in real time can reliably identify stable breathing signals in client-owned cats. The obtained results were significantly different when the SVI method was used in addition to AE. In the interpretation of BWBP parameters or comparison of measurements among studies, whether an SVI methodology was applied should be considered.
    Type of Medium: Online Resource
    ISSN: 1098-612X , 1532-2750
    URL: Article
    DOI: 10.1177/1098612X15592662
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2049047-1
    SSG: 22
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  • 10
    Online Resource
    Online Resource
    Outcome of Canine Multicentric Lymphoma after Single or Divided Treatment with Cyclophosphamide in Multidrug Chemotherapy
    Elsevier BV ; 2020
    In:  Topics in Companion Animal Medicine Vol. 41 ( 2020-11), p. 100461-
    Details
    In: Topics in Companion Animal Medicine, Elsevier BV, Vol. 41 ( 2020-11), p. 100461-
    Type of Medium: Online Resource
    ISSN: 1938-9736
    URL: Article
    DOI: 10.1016/j.tcam.2020.100461
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2428103-7
    SSG: 22
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