In:
Helicobacter, Wiley, Vol. 20, No. 4 ( 2015-08), p. 260-268
Abstract:
The aim of this study was to investigate expression of gastric mucins in children and adolescents and to assess their relations with age and H elicobacter pylori ( H . pylori ) infection. Methods Gastric biopsies were collected from 259 pediatric and adulthood patients with gastrointestinal symptoms among all of patients undergone gastroduodenoscopy from 1990 to 2004 at Gyeongsang National University hospital and assorted based on H . pylori infection, age, and intestinal metaplasia as follows; H . pylori infection before 5 years of age or not, H . pylori infection between 5 and 9 years of age or not, H . pylori infection between 10 and 14 years of age or not, H . pylori infection between 20 and 29 years of age or not and intestinal metaplasia between 21 and 35 years of age. Total 810 tissue slides from the subjects were examined regarding expressions of Mucin2 ( MUC 2), Mucin5 AC ( MUC 5 AC ), and Mucin6 ( MUC 6) in nine groups using immunohistochemical stains. A semiquantitative approach was used to score the staining extent of tissue slide. Results Increased expressions of MUC 2, MUC 5 AC , and MUC 6 were noted in intestinal metaplasia compared with subjects infected with H . pylori between 20 and 29 years. Gastric expressions of MUC 5 AC were decreased in older than 5 years with H . pylori compared with in older than 5 years without H . pylori ( p 〈 .001). Expressions of MUC 2 and MUC 6 did not change significantly by H . pylori status. Some nuclear expressions of MUC 2 and MUC 6 were noted in children without intestinal metaplasia. Conclusions MUC 5 AC might be affected by chronic H . pylori infection. In addition to biomarkers for intestinal metaplasia or prognostic factors for gastric cancer in adults, MUC 2 and MUC 6 in children might have an another role, based on ectopic gastric nuclear expressions of MUC 2 and MUC 6 in children without intestinal metaplasia.
Type of Medium:
Online Resource
ISSN:
1083-4389
,
1523-5378
DOI:
10.1111/hel.2015.20.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2020336-6
SSG:
12
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