In:
Open Medicine, Walter de Gruyter GmbH, Vol. 10, No. 1 ( 2015-9-4)
Abstract:
Chemical pleurodesis is an effective treatment
modality to reduce recurrence of malignant effusion. Several agents have been used in chemical pleurodesis
but, it is not yet clear which is better. Eighteen Sprague- Dawley rats were used and classified into three groups:
a group intrapleurally injected normal saline (group A, n=6), 400mg/kg talc (group B, n=6), and 9mg/kg mistletoe
extraction (ME) (group C, n=6). Autopsy was performed to evaluate the pleural adhesion, pathologic examination of
pleura and lung and bronchoalveolar lavage fluid analysis 4 weeks after pleurodesis. Both group B and C showed an
obvious pleural adhesion and there was no significant difference in grade of pleural adhesion between two groups
(p=0.58). The parietal pleural thickness in talc group than ME group was significantly thicker (p=0.002) and the visceral
pleura of talc group showed marked foreign body reaction with fibrosis and many multinucleated giant
cells associated with talc crystal . This study suggests that
pleurodesis using ME in condition without malignancy has comparable effect to pleurodesis using talc. However,
additional experimental study in large animal or clinical trials would be required to prove a safety and an efficacy of pleurodesis using ME.
Type of Medium:
Online Resource
ISSN:
2391-5463
DOI:
10.1515/med-2015-0051
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2015
detail.hit.zdb_id:
2829380-0
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