In:
Bulletin of the Korean Chemical Society, Wiley, Vol. 36, No. 6 ( 2015-06), p. 1586-1593
Abstract:
We identified azabicyclo[3.1.0]hexane derivatives that are active diacylglycerol acyltransferase‐1 ( DGAT )‐1 inhibitor. Among the azabicyclo[3.1.0]hexane series, compound 6b showed good in vitro activity toward human DGAT ‐1, selectivity toward DGAT ‐2, and liver microsomal stability. Compound 6b exhibited no CYP inhibition, hERG binding, or cell cytotoxicity. Additionally, compound 6b reduced the level of plasma triglyceride after oral administration in mice.
Type of Medium:
Online Resource
ISSN:
1229-5949
,
1229-5949
DOI:
10.1002/bkcs.2015.36.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2056474-0
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