In:
Journal of Immunology Research, Hindawi Limited, Vol. 2015 ( 2015), p. 1-18
Abstract:
Studies of chemokine receptors (CKR) in natural killer- (NK-) cells have already been published, but only a few gave detailed information on its differential expression on blood NK-cell subsets. We report on the expression of the inflammatory and homeostatic CKR on normal blood CD56 + low CD16 + and CD56 + high CD16 - / + low NK-cells. Conventional CD56 + low and CD56 + high NK-cells present in the normal PB do express CKR for inflammatory cytokines, although with different patterns CD56 + low NK-cells are mainly CXCR1/CXCR2 + and CXCR3/CCR5 −/+ , whereas mostly CD56 + high NK-cells are CXCR1/CXCR2 − and CXCR3/CCR5 + . Both NK-cell subsets have variable CXCR4 expression and are CCR4 − and CCR6 − . The CKR repertoire of the CD56 + low NK-cells approaches to that of neutrophils, whereas the CKR repertoire of the CD56 + high NK-cells mimics that of Th1 + T cells, suggesting that these cells are prepared to migrate into inflamed tissues at different phases of the immune response. In addition, we describe a subpopulation of NK-cells with intermediate levels of CD56 expression, which we named CD56 + int NK-cells. These NK-cells are CXCR3/CCR5 + , they have intermediate levels of expression of CD16, CD62L, CD94, and CD122, and they are CD57 − and CD158a − . In view of their phenotypic features, we hypothesize that they correspond to a transitional stage, between the well-known CD56 + high and CD56 + low NK-cells populations.
Type of Medium:
Online Resource
ISSN:
2314-8861
,
2314-7156
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2015
detail.hit.zdb_id:
2817541-4
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