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  • 1
    Online Resource
    Online Resource
    S. Karger AG ; 2022
    In:  Case Reports in Neurology Vol. 14, No. 1 ( 2022-3-15), p. 124-129
    In: Case Reports in Neurology, S. Karger AG, Vol. 14, No. 1 ( 2022-3-15), p. 124-129
    Abstract: Vitamin D deficiency is becoming more common around the world, owing to reduced sunshine exposure and an imbalanced diet. However, severe hypocalcemia as a result of vitamin D insufficiency is a rare occurrence, and it rarely leads to seizures in children. We present such a case in a 6-month-old infant who presented with status epilepticus secondary to hypocalcemia due to vitamin D deficiency, which was first misdiagnosed as epilepsy. Thereby, we want to emphasize that hypocalcemia secondary to vitamin D deficiency can lead to convulsion and the importance of vitamin D supplementation.
    Type of Medium: Online Resource
    ISSN: 1662-680X
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 2505302-4
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  • 2
    In: Romanian Journal of Neurology, AMALTEA Medical Publishing House, Vol. 21, No. 2 ( 2022-06-30), p. 189-192
    Abstract: Vitamin D deficiency is becoming more common around the world, owing to reduced sunshine exposure and an imbalanced diet. However, severe hypocalcemia as a result of vitamin D insufficiency is a rare occurrence, and it seldom leads to seizures in children. We present such a case in a 6-month-old infant who presented status epilepticus secondary to hypocalcemia due to vitamin D deficiency, which was first misdiagnosed as epilepsy. Thereby we want to emphasize that hypocalcemia secondary to vitamin D deficiency can lead to convulsion and the importance of vitamin D supplementation.
    Type of Medium: Online Resource
    ISSN: 1843-8148 , 2069-6094
    URL: Issue
    Language: Unknown
    Publisher: AMALTEA Medical Publishing House
    Publication Date: 2022
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  • 3
    In: AIMS Medical Science, American Institute of Mathematical Sciences (AIMS), Vol. 8, No. 2 ( 2021), p. 163-174
    Type of Medium: Online Resource
    ISSN: 2375-1576
    Language: Unknown
    Publisher: American Institute of Mathematical Sciences (AIMS)
    Publication Date: 2021
    detail.hit.zdb_id: 2813969-0
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  • 4
    Online Resource
    Online Resource
    Hue University of Medicine and Pharmacy ; 2021
    In:  Journal of Medicine and Pharmacy
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy
    Abstract: Objectives: To investigate the relationship between the concentration of urinary soluble urokinase plasminogen activator (suPAR) pretreatment with the treatment responsiveness in children with primary nephrotic syndrome. Methods: Longitudinal follow-up study. Results: A study of 30 children diagnosed with the initial nephrotic syndrome was followed up at Hue Pediatric Center of Hue Central Hospital and Pediatrics Departement of Hue University of Medicine and Pharmacy Hospital. Urinary suPAR/creatinine ratio was 2712 ± 2217 pg/mg (605 - 11443 pg/mg), urinary suPAR/creatinine ratio in children 1-6 years old was significantly higher than that in group 7-15 years old, there was no signifficant difference about urinary suPAR between hematuria and non-hematuria group. Urinary suPAR/creatinine ratio was not significantly associated with serum albumin, glomerular filtration rate and proteinuria. After 2 months of steroid treatment, 100% patients was completely remission. Following- up 28 patients after 6 months of steroid treatment: the rate of completely remission, infrequent relapse and frequent relapse were 67.8%, 25% and 7.2% respectively, there was no signifficant difference about urinary suPAR/creatinine ratio among three groups. Conclusions: Pre-treatment urinary suPAR/creatinine ratio do not help predict the ability of steroid responsiveness in the early period of treatment. More research is needed to understand more the role of urinary suPAR in pediatric nephrotic syndrome. Key words: soluble urokinase plasminogen activator, urinary suPAR, childhood nephrotic syndrome
    Type of Medium: Online Resource
    ISSN: 1859-3836
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2021
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  • 5
    Online Resource
    Online Resource
    Vietnam Association of Diabetes and Endocrinology ; 2021
    In:  Vietnam Journal of Diabetes and Endocrinology , No. 43 ( 2021-01-28), p. 73-77
    In: Vietnam Journal of Diabetes and Endocrinology, Vietnam Association of Diabetes and Endocrinology, , No. 43 ( 2021-01-28), p. 73-77
    Abstract: Mục tiêu: Khảo sát nồng độ suPAR niệu (soluble urokinase plasminogen activator) trước điều trị với các đặc điểm lâm sàng, cận lâm sàng và mức độ đáp ứng điều trị giai đoạn sớm trong bệnh hội chứng thận hư (HCTH) tiên phát lần đầu ở trẻ em. Phương pháp:Nghiên cứu theo dõi dọc các trường hợp bệnh. Kết quả: Nghiên cứu trên 30 trẻ em được chẩn đoán HCTH lần đầu có theo dõi tại Trung tâm Nhi khoa Huế và khoa Nhi bệnh viện Trường Đại học Y Dược Huế, thấy nồng độ suPAR/creatinin niệu 2712±2217 pg/mg (605-11443 pg/ mg), nồng độ suPAR niệu/ creatinin niệu ở nhóm bệnh nhi 1-6 tuổi cao hơn có ý nghĩa so với nhóm bệnh nhi 7-15 tuổi, không có sự khác biệt giữa nhóm có đái máu và không đái máu. Nồng độ suPAR/ creatinin niệu không mối liên quan có ý nghĩa với albumin máu, mức lọc cầu thận và protein niệu. Sau giai đoạn tấn công, 100% bệnh nhi đáp ứng hoàn toàn với điều trị nên nồng độ suPAR niệu/creatinin niệu không giúp dự báo đáp ứng sau giai đoạn điều trị tấn công ở bệnh nhi HCTH. Kết luận: Nồng độ suPAR niệu/ creatinin niệu không có mối liên quan với đái máu, albumin máu, protein niệu. Nồng độ suPAR niệu/ creatinin niệu trước điều trị không giúp tiên đoán khả năng đáp ứng điều trị giai đoạn sớm. Cần nhiều nghiên cứu hơn để hiểu thêm về vai trò của suPAR niệu ở HCTH trẻ em.
    Type of Medium: Online Resource
    ISSN: 1859-4727
    URL: Issue
    Language: Unknown
    Publisher: Vietnam Association of Diabetes and Endocrinology
    Publication Date: 2021
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  • 6
    Online Resource
    Online Resource
    Hue University of Medicine and Pharmacy ; 2020
    In:  Journal of Medicine and Pharmacy
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy
    Abstract: A 18-month-old-girl presented with five months history of progressive edema and pallor. Nutritional his-tory revealed long-standing excessive cow milk intake. She was found to be profoundly severe iron deficiency anemia and hypoproteinemic, gastroendoscopy revealed many lessions in duodenum. RIDA qLine Allergy test is positive with cow milk, casein and bovin serum albumin. She was treated with cow milk restriction and oral iron supplements, which resulted in resolution of her edema and laboratory anomalies within two month. Cow’s milk allergy frequently presents with eczema, diarrhea, wheezing…while iron deficiency and hypopro-teinemic are quite rare. We report this case with the aim of providing clues for pediatricians for diagnosis and treatment of this disease. Key words: edema, hypoproteinemic, iron deficiency, cow’s milk allergy
    Type of Medium: Online Resource
    ISSN: 1859-3836
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2020
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  • 7
    Online Resource
    Online Resource
    Hue University of Medicine and Pharmacy ; 2020
    In:  Journal of Medicine and Pharmacy
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy
    Abstract: Childhood sarcoidosis is an uncommon disease and recognition of this disease in children is often delayed because of the lack of awareness and unfamiliarity with its clinical features. With the aim of providing clues for diagnosis and treatment of disease, we reported a a 23-month-old boy hospitalized for multiple pinkish papules  and painless cystic swellings in ankles and wrists, diagnosed with sarcoidosis, treated with corticosteroid and well recovered. This case reminds us to include childhood sarcoidosis in the differential diagnosis in pediatric patients who present with multiple papular eruptions along with systemic manifestations. It is characterized by arthritis, uveitis, and cutaneous involvement. The prognosis of early-onset childhood sarcoidosis varies in different studies due to the rarity of the disease. The treatment of choice in systemic involvement of childhood sarcoidosis is corticosteroids. Key words: sarcoidosis in children, childhood sarcoidosis, granulomatous disorder, arthritis, uveitis.
    Type of Medium: Online Resource
    ISSN: 1859-3836
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2020
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  • 8
    Online Resource
    Online Resource
    Vietnam Association of Diabetes and Endocrinology ; 2021
    In:  Vietnam Journal of Diabetes and Endocrinology , No. 43 ( 2021-01-28), p. 89-93
    In: Vietnam Journal of Diabetes and Endocrinology, Vietnam Association of Diabetes and Endocrinology, , No. 43 ( 2021-01-28), p. 89-93
    Abstract: Tăng sản thượng thận bẩm sinh là một bệnh lý hiếm gặp, cần điều trị suốt đời. Trong quá trình điều trị trẻ sẽ có thể xuất hiện sớm trước 8,9 tuổi các đặc tính sinh dục của giai đoạn dậy thì như có lông mu, ngực lớn… làm các bác sĩ lâm sàng khá băn khoăn về nguyên nhân thực sự của nó. Chúng tôi báo cáo 2 trường hợp dậy thì sớm ở trẻ tăng sản thượng thận bẩm sinh nhằm cung cấp thêm dữ liệu lâm sàng cho các đồng nghiệp trong tiếp cận và chẩn đoán.
    Type of Medium: Online Resource
    ISSN: 1859-4727
    URL: Issue
    Language: Unknown
    Publisher: Vietnam Association of Diabetes and Endocrinology
    Publication Date: 2021
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  • 9
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2022
    In:  Egyptian Pediatric Association Gazette Vol. 70, No. 1 ( 2022-09-05)
    In: Egyptian Pediatric Association Gazette, Springer Science and Business Media LLC, Vol. 70, No. 1 ( 2022-09-05)
    Abstract: Focal segmental glomerulosclerosis (FSGS) is a chronic glomerular disease that responds poorly to treatment, with a large proportion of patients progressing to end-stage renal disease in spite of initial aggressive treatment. It is worth emphasizing that the FSGS group has still a high recurrence rate after kidney transplantation. Therefore, understanding the factors involved in the pathogenesis of FSGS will help nephrologists better understand the pathogenesis as well as find out specific targeted therapies. Circulating immune factors have long been implicated in the pathogenesis of FSGS, and recent studies have suggested that soluble urokinase plasminogen activator receptor (suPAR) is one of the good candidates for this hypothesis. The aim of this review study was to analyze the value of suPAR in glomerular disease, especially in clinical studies. Methods In this review study, the PubMed database was searched using relevant keywords (suPAR, circulating permeability factors Children, FSGS, and children). Descriptive and cross-sectional studies were reviewed in the current study with the main focuses on the role of suPAR in FSGS, nephrotic syndrome, and the relation to progression of renal failure, especially the research in children. Results Overall, 32 studies from different countries were selected. These clinical studies on suPAR have shown the following: (i) the role of suPAR in the diagnosis of FSGS has not yet been confirmed, and (ii) there is strong evidence demonstrating a significant relationship between suPAR and the severity of kidney disease as well as a high value of suPAR in predicting the steroid responsiveness of nephrotic syndrome. Conclusion Researching on circulating permeability factors in FSGS is a current trend, which opens new avenues in targeted diagnosis and treatment. suPAR is a promising candidate, and urinary suPAR has also shown advantages over serum suPAR; therefore, more research on this issue is needed in the future.
    Type of Medium: Online Resource
    ISSN: 2090-9942
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2841599-1
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  • 10
    In: Critical Care, Springer Science and Business Media LLC, Vol. 27, No. 1 ( 2023-07-01)
    Abstract: Interpreting point-of-care lung ultrasound (LUS) images from intensive care unit (ICU) patients can be challenging, especially in low- and middle- income countries (LMICs) where there is limited training available. Despite recent advances in the use of Artificial Intelligence (AI) to automate many ultrasound imaging analysis tasks, no AI-enabled LUS solutions have been proven to be clinically useful in ICUs, and specifically in LMICs. Therefore, we developed an AI solution that assists LUS practitioners and assessed its usefulness in  a low resource ICU. Methods This was a three-phase prospective study. In the first phase, the performance of four different clinical user groups in interpreting LUS clips was assessed. In the second phase, the performance of 57 non-expert clinicians with and without the aid of a bespoke AI tool for LUS interpretation was assessed in retrospective offline clips. In the third phase, we conducted a prospective study in the ICU where 14 clinicians were asked to carry out LUS examinations in 7 patients with and without our AI tool and we interviewed the clinicians regarding the usability of the AI tool. Results The average accuracy of beginners’ LUS interpretation was 68.7% [95% CI 66.8–70.7%] compared to 72.2% [95% CI 70.0–75.6%] in intermediate, and 73.4% [95% CI 62.2–87.8%] in advanced users. Experts had an average accuracy of 95.0% [95% CI 88.2–100.0%] , which was significantly better than beginners, intermediate and advanced users ( p   〈  0.001). When supported by our AI tool for interpreting retrospectively acquired clips, the non-expert clinicians improved their performance from an average of 68.9% [95% CI 65.6–73.9%] to 82.9% [95% CI 79.1–86.7%] , ( p   〈  0.001). In prospective real-time testing, non-expert clinicians improved their baseline performance from 68.1% [95% CI 57.9–78.2%] to 93.4% [95% CI 89.0–97.8%] , ( p   〈  0.001) when using our AI tool. The time-to-interpret clips improved from a median of 12.1 s (IQR 8.5–20.6) to 5.0 s (IQR 3.5–8.8), ( p   〈  0.001) and clinicians’ median confidence level improved from 3 out of 4 to 4 out of 4 when using our AI tool. Conclusions AI-assisted LUS can help non-expert clinicians in an LMIC ICU improve their performance in interpreting LUS features more accurately, more quickly and more confidently.
    Type of Medium: Online Resource
    ISSN: 1364-8535
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2051256-9
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