In:
EMBO reports, EMBO, Vol. 21, No. 2 ( 2020-02-05)
Abstract:
image This study reveals that MitoT directly shapes the immune response by inducing Tregs, which could be potentially used as a therapy for autoimmune diseases such as GVHD. Mitochondria are transferred from MSCs to CD4 + T cells. Mitochondrial transfer promotes Treg differentiation. Transplantation of mitochondria recipient human T cells alleviates inflammatory response and tissue damage in GVDH and SLE disease models.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.201948052
Language:
English
Publisher:
EMBO
Publication Date:
2020
detail.hit.zdb_id:
2025376-X
SSG:
12
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