In:
PLOS Biology, Public Library of Science (PLoS), Vol. 18, No. 11 ( 2020-11-24), p. e3000926-
Abstract:
Devil facial tumour 1 (DFT1) is a transmissible cancer clone endangering the Tasmanian devil. The expansion of DFT1 across Tasmania has been documented, but little is known of its evolutionary history. We analysed genomes of 648 DFT1 tumours collected throughout the disease range between 2003 and 2018. DFT1 diverged early into five clades, three spreading widely and two failing to persist. One clade has replaced others at several sites, and rates of DFT1 coinfection are high. DFT1 gradually accumulates copy number variants (CNVs), and its telomere lengths are short but constant. Recurrent CNVs reveal genes under positive selection, sites of genome instability, and repeated loss of a small derived chromosome. Cultured DFT1 cell lines have increased CNV frequency and undergo highly reproducible convergent evolution. Overall, DFT1 is a remarkably stable lineage whose genome illustrates how cancer cells adapt to diverse environments and persist in a parasitic niche.
Type of Medium:
Online Resource
ISSN:
1545-7885
DOI:
10.1371/journal.pbio.3000926
DOI:
10.1371/journal.pbio.3000926.g001
DOI:
10.1371/journal.pbio.3000926.g002
DOI:
10.1371/journal.pbio.3000926.g003
DOI:
10.1371/journal.pbio.3000926.t001
DOI:
10.1371/journal.pbio.3000926.t002
DOI:
10.1371/journal.pbio.3000926.t003
DOI:
10.1371/journal.pbio.3000926.t004
DOI:
10.1371/journal.pbio.3000926.t005
DOI:
10.1371/journal.pbio.3000926.t006
DOI:
10.1371/journal.pbio.3000926.s001
DOI:
10.1371/journal.pbio.3000926.s002
DOI:
10.1371/journal.pbio.3000926.s003
DOI:
10.1371/journal.pbio.3000926.s004
DOI:
10.1371/journal.pbio.3000926.s005
DOI:
10.1371/journal.pbio.3000926.s006
DOI:
10.1371/journal.pbio.3000926.s007
DOI:
10.1371/journal.pbio.3000926.s008
DOI:
10.1371/journal.pbio.3000926.s009
DOI:
10.1371/journal.pbio.3000926.s010
DOI:
10.1371/journal.pbio.3000926.s011
DOI:
10.1371/journal.pbio.3000926.s012
DOI:
10.1371/journal.pbio.3000926.s013
DOI:
10.1371/journal.pbio.3000926.s014
DOI:
10.1371/journal.pbio.3000926.s015
DOI:
10.1371/journal.pbio.3000926.s016
DOI:
10.1371/journal.pbio.3000926.s017
DOI:
10.1371/journal.pbio.3000926.s018
DOI:
10.1371/journal.pbio.3000926.s019
DOI:
10.1371/journal.pbio.3000926.s020
DOI:
10.1371/journal.pbio.3000926.s021
DOI:
10.1371/journal.pbio.3000926.s022
DOI:
10.1371/journal.pbio.3000926.s023
DOI:
10.1371/journal.pbio.3000926.s024
DOI:
10.1371/journal.pbio.3000926.s025
DOI:
10.1371/journal.pbio.3000926.r001
DOI:
10.1371/journal.pbio.3000926.r002
DOI:
10.1371/journal.pbio.3000926.r003
DOI:
10.1371/journal.pbio.3000926.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2126773-X
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