In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 19, No. 3 ( 2023-3-28), p. e1011282-
Abstract:
In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about the impacts of gestational African-lineage ZIKV infections. Given high human immunodeficiency virus (HIV) burdens in regions where African-lineage ZIKV circulates, we evaluated whether pregnant rhesus macaques infected with simian immunodeficiency virus (SIV) have a higher risk of African-lineage ZIKV-associated birth defects. Remarkably, in both SIV+ and SIV- animals, ZIKV infection early in the first trimester caused a high incidence (78%) of spontaneous pregnancy loss within 20 days. These findings suggest a significant risk for early pregnancy loss associated with African-lineage ZIKV infection and provide the first consistent ZIKV-associated phenotype in macaques for testing medical countermeasures.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1011282
DOI:
10.1371/journal.ppat.1011282.g001
DOI:
10.1371/journal.ppat.1011282.g002
DOI:
10.1371/journal.ppat.1011282.g003
DOI:
10.1371/journal.ppat.1011282.g004
DOI:
10.1371/journal.ppat.1011282.g005
DOI:
10.1371/journal.ppat.1011282.g006
DOI:
10.1371/journal.ppat.1011282.s001
DOI:
10.1371/journal.ppat.1011282.s002
DOI:
10.1371/journal.ppat.1011282.s003
DOI:
10.1371/journal.ppat.1011282.s004
DOI:
10.1371/journal.ppat.1011282.s005
DOI:
10.1371/journal.ppat.1011282.s006
DOI:
10.1371/journal.ppat.1011282.s007
DOI:
10.1371/journal.ppat.1011282.s008
DOI:
10.1371/journal.ppat.1011282.s009
DOI:
10.1371/journal.ppat.1011282.s010
DOI:
10.1371/journal.ppat.1011282.s011
DOI:
10.1371/journal.ppat.1011282.s012
DOI:
10.1371/journal.ppat.1011282.s013
DOI:
10.1371/journal.ppat.1011282.s014
DOI:
10.1371/journal.ppat.1011282.s015
DOI:
10.1371/journal.ppat.1011282.s016
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2205412-1
Permalink