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  • 1
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2006
    In:  Thrombosis and Haemostasis Vol. 95, No. 02 ( 2006), p. 373-379
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 95, No. 02 ( 2006), p. 373-379
    Abstract: Haemophilia A is an X-linked, recessive, inherited bleeding disorder which affects 1 in 5000 males born worldwide. It is caused by mutations in the FactorVIII (F8) gene on chromosome Xq28. We describe for the first time two mutation specific, single cell protocols for pre-implantation genetic diagnosis (PGD) of haemophilia A that enable the selection of both male and female unaffected embryos. This approach offers an alternative to sexing, frequently used for X-linked disorders, that results in the discarding of all male embryos including the 50% that would have been normal. Two families witha history of severe haemophilia A requested carrier diagnosis and subsequently proceeded to PGD. The mutation in family1 isa single nucleotide substitution c. 5953C 〉 T, R1966X in exon 18 and in family 2, c. 5122C 〉 T, R1689C in exon 14 of the F8 gene. Amplification efficiency was compared between distilled water and SDS/proteinase K cell lysis (98.0%, 96/98 and 80%, 112/140 respectively) using 238 single lymphocytes. Blastomeres from spare IVF cleavage-stage embryos donated for research showed amplification efficiencies of 83.3% (45/54) for the R1966X and 92.9% (13/14) for the R1689C mutations. The rate of allele dropout (ADO) on heterozygous lymphocytes was 1.1% (1/93) for R1966X and 5.94% (6/101) for R1689C mutations. A single PGD treatment cycle for family1 resulted in two embryos for transfer but these failed to implant. However, with family 2, two embryos were transferred to the uterus on day 4 resulting in a successful singleton pregnancy and subsequent live birth of a normal non-carrier female.
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2006
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  • 2
    Online Resource
    Online Resource
    Wiley ; 2004
    In:  British Journal of Clinical Psychology Vol. 43, No. 2 ( 2004-06), p. 129-142
    In: British Journal of Clinical Psychology, Wiley, Vol. 43, No. 2 ( 2004-06), p. 129-142
    Abstract: Objectives: Future thinking is an important domain of cognitive functioning, with reduced ability to imagine positive future events associated with hopelessness in depression and parasuicide. Rumination has been shown to exacerbate negative cognitive biases in depression, and to reduce likelihood estimations for positive future events. We examine the hypothesis that, in depressed patients, rumination would reduce the ability to imagine positive future events, whilst increasing the ability to imagine negative future events. Method: The ability to imagine positive and negative future events was assessed using the future thinking paradigm (MacLeod, Rose, & Williams, 1993). Depressed and nondepressed participants completed the future thinking task after being randomly allocated to either a rumination or distraction manipulation (Nolen‐Hoeksema & Morrow, 1993). Mood was measured before and after the manipulation. Participants also completed a standard verbal fluency task. Results: In the depressed group, compared to distraction, rumination increased both negative and positive future thinking, although the effect was only significant for negative future thinking once baseline levels of hopelessness were controlled for. These findings are consistent with the prediction that rumination would increase negative future thinking, but inconsistent with the prediction that rumination would reduce positive future thinking. Previous findings that, compared to controls, depressed patients generated fewer positive future events were replicated. Conclusion: Ruminative self‐focus leads to greater negative future thinking in depressed patients, further confirming that rumination exacerbates negative cognitive biases in depression. The relationship between rumination and positive future thinking was unexpected, but might potentially reflect a general priming of self‐related information by rumination.
    Type of Medium: Online Resource
    ISSN: 0144-6657 , 2044-8260
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2004
    detail.hit.zdb_id: 1491701-4
    SSG: 5,2
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  • 3
    In: Marine Biology, Springer Science and Business Media LLC, Vol. 168, No. 11 ( 2021-11)
    Abstract: Trends in depth and vertical activity reflect the behaviour, habitat use and habitat preferences of marine organisms. However, among elasmobranchs, research has focused heavily on pelagic sharks, while the vertical movements of benthic elasmobranchs, such as skate (Rajidae), remain understudied. In this study, the vertical movements of the Critically Endangered flapper skate ( Dipturus intermedius ) were investigated using archival depth data collected at 2 min intervals from 21 individuals off the west coast of Scotland (56.5°N, −5.5°W) in 2016–17. Depth records comprised nearly four million observations and included eight time series longer than 1 year, forming one of the most comprehensive datasets collected on the movement of any skate to date. Additive modelling and functional data analysis were used to investigate vertical movements in relation to environmental cycles and individual characteristics. Vertical movements were dominated by individual variation but included prolonged periods of limited activity and more extensive movements that were associated with tidal, diel, lunar and seasonal cycles. Diel patterns were strongest, with irregular but frequent movements into shallower water at night, especially in autumn and winter. This research strengthens the evidence for vertical movements in relation to environmental cycles in benthic species and demonstrates a widely applicable flexible regression framework for movement research that recognises the importance of both individual-specific and group-level variation.
    Type of Medium: Online Resource
    ISSN: 0025-3162 , 1432-1793
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 1117-4
    detail.hit.zdb_id: 1459413-4
    SSG: 12
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  • 4
    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 8 ( 2021-9-21)
    Type of Medium: Online Resource
    ISSN: 2296-7745
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2757748-X
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  • 5
    In: Surveys in Geophysics, Springer Science and Business Media LLC, Vol. 44, No. 5 ( 2023-10), p. 1357-1446
    Abstract: This review paper reports on the state-of-the-art concerning observations of surface winds, waves, and currents from space and their use for scientific research and subsequent applications. The development of observations of sea state parameters from space dates back to the 1970s, with a significant increase in the number and diversity of space missions since the 1990s. Sensors used to monitor the sea-state parameters from space are mainly based on microwave techniques. They are either specifically designed to monitor surface parameters or are used for their abilities to provide opportunistic measurements complementary to their primary purpose. The principles on which is based on the estimation of the sea surface parameters are first described, including the performance and limitations of each method. Numerous examples and references on the use of these observations for scientific and operational applications are then given. The richness and diversity of these applications are linked to the importance of knowledge of the sea state in many fields. Firstly, surface wind, waves, and currents are significant factors influencing exchanges at the air/sea interface, impacting oceanic and atmospheric boundary layers, contributing to sea level rise at the coasts, and interacting with the sea-ice formation or destruction in the polar zones. Secondly, ocean surface currents combined with wind- and wave- induced drift contribute to the transport of heat, salt, and pollutants. Waves and surface currents also impact sediment transport and erosion in coastal areas. For operational applications, observations of surface parameters are necessary on the one hand to constrain the numerical solutions of predictive models (numerical wave, oceanic, or atmospheric models), and on the other hand to validate their results. In turn, these predictive models are used to guarantee safe, efficient, and successful offshore operations, including the commercial shipping and energy sector, as well as tourism and coastal activities. Long-time series of global sea-state observations are also becoming increasingly important to analyze the impact of climate change on our environment. All these aspects are recalled in the article, relating to both historical and contemporary activities in these fields.
    Type of Medium: Online Resource
    ISSN: 0169-3298 , 1573-0956
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2017797-5
    SSG: 16,13
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  • 6
    In: Surveys in Geophysics, Springer Science and Business Media LLC, Vol. 44, No. 5 ( 2023-10), p. 1447-1448
    Type of Medium: Online Resource
    ISSN: 0169-3298 , 1573-0956
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2017797-5
    SSG: 16,13
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  • 7
    Online Resource
    Online Resource
    Elsevier BV ; 2020
    In:  Behavioural Brain Research Vol. 390 ( 2020-07), p. 112631-
    In: Behavioural Brain Research, Elsevier BV, Vol. 390 ( 2020-07), p. 112631-
    Type of Medium: Online Resource
    ISSN: 0166-4328
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2013604-3
    SSG: 12
    SSG: 5,2
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  • 8
    In: American Journal of Ophthalmology, Elsevier BV, Vol. 163 ( 2016-03), p. 140-147.e1
    Type of Medium: Online Resource
    ISSN: 0002-9394
    RVK:
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 2019600-3
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  • 9
    Online Resource
    Online Resource
    Wiley ; 2022
    In:  Aquatic Conservation: Marine and Freshwater Ecosystems Vol. 32, No. 2 ( 2022-02), p. 348-365
    In: Aquatic Conservation: Marine and Freshwater Ecosystems, Wiley, Vol. 32, No. 2 ( 2022-02), p. 348-365
    Abstract: Marine Protected Areas (MPAs) are widely used in marine management, but for mobile species understanding the spatio‐temporal scale of management measures that is required to deliver conservation benefits depends on a detailed knowledge of species’ movements that is often lacking. This is especially the case for species of skate (Rajidae) for which relatively few movement studies have been conducted. In Scotland, the Loch Sunart to the Sound of Jura MPA covering 741 km 2 has been designated for the conservation of the Critically Endangered flapper skate ( Dipturus intermedius ), but fine‐scale movements within this area remain poorly understood. A passive acoustic telemetry study which coupled acoustic tagging of 42 individuals and a static array of 58 receivers was conducted from March 2016 to June 2017. Using acoustic detection time series, angler capture–recapture data and depth time series from archival tags, fine‐scale movements of individuals were investigated. Overall, 33 of the 42 tagged individuals were detected. Residency, site fidelity and transiency were documented. Residency around receivers, lasting from 3 to more than 12 months, was documented in 16 acoustically detected individuals (48%) and all life‐history categories, but was most noticeable among females. Acoustic detections were associated with depth, salinity and season, but there was no evidence that individuals formed close‐knit groups in the areas in which they were detected. Taken together with historical occurrence records of flapper skate, the prevalence and scale of residency documented here suggest that the MPA is sufficiently large to benefit a notable percentage (38 [24–52]%) of skate found in the study area over monthly and seasonal timescales. This result strengthens the case for the use of MPAs to support the conservation of flapper skate and other skate species that display similar movement patterns in areas of high local abundance.
    Type of Medium: Online Resource
    ISSN: 1052-7613 , 1099-0755
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1146285-1
    detail.hit.zdb_id: 1496050-3
    SSG: 12
    SSG: 14
    SSG: 21
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  • 10
    In: Aquatic Conservation: Marine and Freshwater Ecosystems, Wiley, Vol. 32, No. 10 ( 2022-10), p. 1647-1659
    Abstract: This study provides the first report of an egg nursery for the Critically Endangered flapper skate Dipturus intermedius and a description of the habitat, thus contributing towards our understanding of essential habitats for the species. In total, 1,395 flapper skate egg cases were recorded (accounting for overlapping surveys) in two egg case collection dives ( n  = 67 egg cases), one photogrammetry dive ( n  = 10 egg cases), 509 drop‐down video (DDV) camera drifts ( n  = 510 egg cases) and 18 remote operated vehicle (ROV) flights ( n  = 1,031 egg cases), carried out in the Inner Sound on the west coast of Scotland from 2018 to 2021. All of the egg cases were found on a shallow bedrock plateau between the Isle of Scalpay and a deep ( 〉 100 m) water channel between the Isle of Longay and the Crowlin Islands. Egg cases were observed on a cobble/boulder reef between 25 and 58 m depth, with a modelled annual temperature range of 9–12 °C, modelled current speeds up to 0.2 m −1 , a rugosity index of 1.7 and low levels of sedimentation. Flapper skate egg cases are large and the incubation period is protracted (18 months), making them potentially vulnerable to anthropogenic disturbance. A description of the habitat where egg cases were observed in this study will help inform the search for egg nurseries for this Critically Endangered species elsewhere. Targeted DDV, ROV and scuba diving surveys will support this search in areas where suitable bathymetric and hydrodynamic conditions are identified. Safeguarding egg nurseries is essential for successful conservation. Protection should involve the designation of egg nurseries as Marine Protected Areas where activities that are likely to damage or alter seabed habitats are managed.
    Type of Medium: Online Resource
    ISSN: 1052-7613 , 1099-0755
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1146285-1
    detail.hit.zdb_id: 1496050-3
    SSG: 12
    SSG: 14
    SSG: 21
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