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  • 1
    In: Monthly Weather Review, American Meteorological Society, Vol. 146, No. 11 ( 2018-11-01), p. 3505-3544
    Abstract: Numerical weather, climate, or Earth system models involve the coupling of components. At a broad level, these components can be classified as the resolved fluid dynamics, unresolved fluid dynamical aspects (i.e., those represented by physical parameterizations such as subgrid-scale mixing), and nonfluid dynamical aspects such as radiation and microphysical processes. Typically, each component is developed, at least initially, independently. Once development is mature, the components are coupled to deliver a model of the required complexity. The implementation of the coupling can have a significant impact on the model. As the error associated with each component decreases, the errors introduced by the coupling will eventually dominate. Hence, any improvement in one of the components is unlikely to improve the performance of the overall system. The challenges associated with combining the components to create a coherent model are here termed physics–dynamics coupling. The issue goes beyond the coupling between the parameterizations and the resolved fluid dynamics. This paper highlights recent progress and some of the current challenges. It focuses on three objectives: to illustrate the phenomenology of the coupling problem with references to examples in the literature, to show how the problem can be analyzed, and to create awareness of the issue across the disciplines and specializations. The topics addressed are different ways of advancing full models in time, approaches to understanding the role of the coupling and evaluation of approaches, coupling ocean and atmosphere models, thermodynamic compatibility between model components, and emerging issues such as those that arise as model resolutions increase and/or models use variable resolutions.
    Type of Medium: Online Resource
    ISSN: 0027-0644 , 1520-0493
    RVK:
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2018
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  • 2
    In: Blood, American Society of Hematology, Vol. 124, No. 21 ( 2014-12-06), p. 1694-1694
    Abstract: Background: In young patients with high-risk diffuse large B-cell lymphoma (DLBCL) treatment with R-CHOEP (R-CHOP + etoposide) has been associated with improved outcome. Whether established prognostic markers in R-CHOP treated patients are prognostic in R-CHOEP treated patients remain to be investigated. In addition predictive markers for response to R-CHOEP need to be investigated. Methods: A Danish population based cohort of 140 young (age 18-60) patients with high-risk (2 ≥ additional risk factors including advanced stage, elevated s-LDH, and performance status 〉 1) primary DLBCL diagnosed between 2004 and 2008 was investigated. Patients were treated with R-CHOP (n=84) or R-CHOEP (n=56). Formalin fixed paraffin embedded tumor tissue specimens were analysed for MYC-, BCL2- and BCL6- protein expression by semiquantitative immunohistochemistry (IHC) and genetic translocations by Fluorescence In Situ Hybridization (FISH). Results: MYC protein expression ≥ 40% was seen in 67/106 patients (71%), BCL2 protein expression 〉 0 and BCL2 protein expression ≥ 70% was seen in 106/138 (77%) and 81/117 patients (69%) respectively. BCL6 expression ≥ 30% was seen in 96/114 patients (84%). Concurrent expression of MYC≥40% and BCL2≥70% (IHC double hit (DH)) was seen in 50/106 patients (47%). Concurrent MYC≥40%, BCL2 〉 0 or BCL6 〈 30% (Triple hit (TH) score score 2-3) was seen in 61/103 patients (59%). MYC, BCL2 and BCL6 translocation was seen in 14/104 (13%), 31/104 (30%) and 27/104 (26%) patients respectively. Concurrent MYC BCL2/BCL6 translocation (DH) was seen in 8/102 (8%) patients. MYC over-expression was not associated with reduced progression free survival (PFS) in either R-CHOP or R-CHOEP treated patients. BCL2 expression ( 〉 0%) and BCL2 overexpression (≥70%) was associated with reduced PFS in R-CHOP (HR: 0.3; 95%CI:0.1-0.9; p=0.03 and HR: 0.4; 95%CI: 0.2-0.9; p=0.02) - but not in R-CHOEP treated patients (HR: 0.9; 95%CI:0.3-3.2; p=0.9 and HR: 0.5; 95%CI: 0.1-1.9; p=0.3). IHC DH was associated with a trend towards reduced PFS in R-CHOP - but not in R-CHOEP treated patients (HR: 0.6; 95%CI:0.3-1.1; p=0.08 and HR: 1.2; 95%CI: 0.4-4.0; p=0.7 respectively). TH score 2-3 was associated with reduced PFS in R-CHOP - but not in R-CHOEP treated patients (HR: 0.4; 95%CI:0.2-0.9; p=0.015 and HR: 0.8; 95%CI: 0.2-2.8; p=0.74). There was no statistical significant interaction between treatment modality and BCL2 expression, IHC DH or TH score 2-3. MYC, BCL2 and BCL6 translocations were not prognostic markers with respect to PFS in either R-CHOP or R-CHOP treated patients. DH translocations were too few to perform meaningful statistical analyses. Conclusions: BCL2 expression, IHC DH and TH score 2-3 had prognostic value in R-CHOP treated patients but this was not seen in R-CHOEP treated patients in this study suggesting the need for novel prognostic markers in R-CHOEP treated patients. Neither BCL2 expression, IHC DH nor TH score 2-3 were however predictive markers for response to treatment with R-CHOEP in this cohort of patients. This could possibly be due to the limited number of patients investigated. MYC BCL2/BCL6 DH translocations were too few to perform meaningful statistical analyses and whether DH translocation will retain a prognostic value in R-CHOEP treated patients also remains to be investigated in larger patient cohorts. A possible predictive value of DH translocation also needs further investigation. Disclosures No relevant conflicts of interest to declare.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    RVK:
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    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2014
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  • 3
    In: Journal of Advances in Modeling Earth Systems, American Geophysical Union (AGU), Vol. 14, No. 6 ( 2022-06)
    Abstract: A new configuration of the Community Atmosphere Model with full chemistry supporting horizontal mesh refinement is developed This configuration is the beginning of the Multi‐Scale Infrastructure for Chemistry and Aerosols Updating chemistry and horizontal resolution improves simulated ozone and ozone precursors compared to aircraft observations
    Type of Medium: Online Resource
    ISSN: 1942-2466 , 1942-2466
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2022
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  • 4
    Online Resource
    Online Resource
    American Geophysical Union (AGU) ; 2022
    In:  Journal of Advances in Modeling Earth Systems Vol. 14, No. 11 ( 2022-11)
    In: Journal of Advances in Modeling Earth Systems, American Geophysical Union (AGU), Vol. 14, No. 11 ( 2022-11)
    Abstract: The CESM2.2 release includes several enhancements to the spectral‐element dynamical core, including two Arctic refined mesh configurations Quasi‐uniform unstructured grids degrade Greenland mass balance compared to latitude‐longitude grids at the conventional 1° resolution The refined Arctic meshes substantially improve the surface mass balance over conventional grid resolutions
    Type of Medium: Online Resource
    ISSN: 1942-2466 , 1942-2466
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2022
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  • 5
    Online Resource
    Online Resource
    Elsevier BV ; 2012
    In:  Procedia Computer Science Vol. 9 ( 2012), p. 994-1003
    In: Procedia Computer Science, Elsevier BV, Vol. 9 ( 2012), p. 994-1003
    Type of Medium: Online Resource
    ISSN: 1877-0509
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2012
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  • 6
    Online Resource
    Online Resource
    SAGE Publications ; 2012
    In:  The International Journal of High Performance Computing Applications Vol. 26, No. 1 ( 2012-02), p. 74-89
    In: The International Journal of High Performance Computing Applications, SAGE Publications, Vol. 26, No. 1 ( 2012-02), p. 74-89
    Abstract: The Community Atmosphere Model (CAM) version 5 includes a spectral element dynamical core option from NCAR’s High-Order Method Modeling Environment. It is a continuous Galerkin spectral finite-element method designed for fully unstructured quadrilateral meshes. The current configurations in CAM are based on the cubed-sphere grid. The main motivation for including a spectral element dynamical core is to improve the scalability of CAM by allowing quasi-uniform grids for the sphere that do not require polar filters. In addition, the approach provides other state-of-the-art capabilities such as improved conservation properties. Spectral elements are used for the horizontal discretization, while most other aspects of the dynamical core are a hybrid of well-tested techniques from CAM’s finite volume and global spectral dynamical core options. Here we first give an overview of the spectral element dynamical core as used in CAM. We then give scalability and performance results from CAM running with three different dynamical core options within the Community Earth System Model, using a pre-industrial time-slice configuration. We focus on high-resolution simulations, using 1/4 degree, 1/8 degree, and T341 spectral truncation horizontal grids.
    Type of Medium: Online Resource
    ISSN: 1094-3420 , 1741-2846
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2017480-9
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  • 7
    In: Journal of Geophysical Research: Atmospheres, American Geophysical Union (AGU), Vol. 125, No. 13 ( 2020-07-16)
    Abstract: CESM2 is compared to CESM1 and other CMIP5 and CMIP6 models and ranks highly in many regards Jets, storm tracks, stationary waves, divergent circulation, NAM, SAM, NAO, and blocking are assessed CESM2 has improvements in storm tracks and NH winter circulation but degradations in SH circulation
    Type of Medium: Online Resource
    ISSN: 2169-897X , 2169-8996
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2020
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    detail.hit.zdb_id: 2016800-7
    detail.hit.zdb_id: 2969341-X
    SSG: 16,13
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  • 8
    Online Resource
    Online Resource
    American Meteorological Society ; 2013
    In:  Monthly Weather Review Vol. 141, No. 6 ( 2013-06), p. 2128-2133
    In: Monthly Weather Review, American Meteorological Society, Vol. 141, No. 6 ( 2013-06), p. 2128-2133
    Abstract: It is the purpose of this short article to analyze mass conservation in high-order rigorous remapping schemes, which contrary to flux-based methods, relies on elaborate integral constraints over overlap areas and reconstruction functions. For applications on the sphere these integral constraints may be violated primarily as a result of inexact or ill-conditioned integration and the authors propose a generic, local, and multitracer efficient method that guarantees that the integral constraints are satisfied in discrete space irrespective of the accuracy of the numerical integration method and slight inaccuracies in the computation of overlap areas. The authors refer to this method as enforcement of consistency as it is based on integral constraints valid in continuous space. The consistency enforcement method is illustrated in idealized transport tests with the Conservative Semi-Lagrangian Multitracer scheme (CSLAM) in the High Order Method Modeling Environment (HOMME) where the analytic integrals, which were found to be ill conditioned at certain resolutions and flow conditions, have been replaced with robust quadrature. This violates mass conservation; however, with the consistency enforcement method, mass conservation is inherent even with low-order quadrature and renders rigorous remap schemes such as CSLAM (which was previously limited to gnomonic cubed-sphere grids) mass conservative on any spherical grid.
    Type of Medium: Online Resource
    ISSN: 0027-0644 , 1520-0493
    RVK:
    Language: Unknown
    Publisher: American Meteorological Society
    Publication Date: 2013
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  • 9
    Online Resource
    Online Resource
    American Meteorological Society ; 2015
    In:  Monthly Weather Review Vol. 143, No. 4 ( 2015-04-01), p. 1382-1398
    In: Monthly Weather Review, American Meteorological Society, Vol. 143, No. 4 ( 2015-04-01), p. 1382-1398
    Abstract: A recently developed cell-integrated semi-Lagrangian (CISL) semi-implicit nonhydrostatic atmospheric solver that uses the conservative semi-Lagrangian multitracer (CSLAM) transport scheme is extended to include orographic influences. With the introduction of a new semi-implicit CISL discretization of the continuity equation, the nonhydrostatic solver, called CSLAM-NH, has been shown to ensure inherently conservative and numerically consistent transport of air mass and other scalar variables, such as moisture and passive tracers. The extended CSLAM-NH presented here includes two main modifications: transformation of the equation set to a terrain-following height coordinate to incorporate orography and an iterative centered-implicit time-stepping scheme to enhance the stability of the scheme associated with gravity wave propagation at large time steps. CSLAM-NH is tested for a suite of idealized 2D flows, including linear mountain waves (dry), a downslope windstorm (dry), and orographic cloud formation.
    Type of Medium: Online Resource
    ISSN: 0027-0644 , 1520-0493
    RVK:
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2015
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    SSG: 14
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  • 10
    Online Resource
    Online Resource
    American Meteorological Society ; 2015
    In:  Journal of the Atmospheric Sciences Vol. 72, No. 5 ( 2015-05-01), p. 2183-2197
    In: Journal of the Atmospheric Sciences, American Meteorological Society, Vol. 72, No. 5 ( 2015-05-01), p. 2183-2197
    Abstract: In the continued effort to understand the climate system and improve its representation in atmospheric general circulation models (AGCMs), it is crucial to develop reduced-complexity frameworks to evaluate these models. This is especially true as the AGCM community advances toward high horizontal resolutions (i.e., grid spacing less than 50 km), which will require interpreting and improving the performance of many model components. A simplified global radiative–convective equilibrium (RCE) configuration is proposed to explore the implication of horizontal resolution on equilibrium climate. RCE is the statistical equilibrium in which the radiative cooling of the atmosphere is balanced by heating due to convection. In this work, the Community Atmosphere Model, version 5 (CAM5), is configured in RCE to better understand tropical climate and extremes. The RCE setup consists of an ocean-covered Earth with diurnally varying, spatially uniform insolation and no rotation effects. CAM5 is run at two horizontal resolutions: a standard resolution of approximately 100-km grid spacing and a high resolution of approximately 25-km spacing. Surface temperature effects are considered by comparing simulations using fixed, uniform sea surface temperature with simulations using an interactive slab-ocean model. The various CAM5 configurations provide useful insights into the simulation of tropical climate as well as the model’s ability to simulate extreme precipitation events. In particular, the manner in which convection organizes is shown to be dependent on model resolution and the surface configuration (including surface temperature), as evident by differences in cloud structure, circulation, and precipitation intensity.
    Type of Medium: Online Resource
    ISSN: 0022-4928 , 1520-0469
    RVK:
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2015
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    SSG: 16,13
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