In:
European Journal of Organic Chemistry, Wiley, Vol. 2006, No. 2 ( 2006-01), p. 436-448
Abstract:
The synthesis of oligonucleotides from dimers to a hexamer by a H ‐phosphonate approach in solution using solid‐supported acyl chloride is reported herein. This strategy avoids the use of chromatography. The work‐ups have been simplified and involve filtration, aqueous extraction and precipitation. The synthesis was scaled up to 1 mmol for the dimers and 340 μmol for the hexamer. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2006:2
DOI:
10.1002/ejoc.200500547
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
1475010-7
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