In:
Frontiers in Medicine, Frontiers Media SA, Vol. 9 ( 2022-2-15)
Abstract:
Sepsis, a complex multisystem disorder, is among the top causes of hospitalization and mortality in older adults. However, the mechanisms underlying the disproportionate susceptibility to sepsis and worse outcomes in the elderly are not well understood. Recently, changes in DNA methylation have been shown to be linked to aging processes and age-related diseases. Thus, we postulated that age-related changes in DNA methylation may play a role in the onset and prognosis of sepsis in elderly patients. Here, we performed genome-wide methylation profiling of peripheral blood from patients with sepsis and controls. Among the CpG sites whose methylation changes may contribute to an increase in sepsis susceptibility or mortality, 241 sites that possessed age-related changes in DNA methylation in controls may partly explain the increased risk of sepsis in older adults, and 161 sites whose methylation significantly correlated with age in sepsis group may be the potential mechanisms underlying the worse outcomes of elderly septic patients. Finally, an independent cohort was used to validate our findings. Together, our study demonstrates that age-related changes in DNA methylation may explain in part the disproportionate susceptibility and worse outcomes of sepsis in older adults.
Type of Medium:
Online Resource
ISSN:
2296-858X
DOI:
10.3389/fmed.2022.822847
DOI:
10.3389/fmed.2022.822847.s001
DOI:
10.3389/fmed.2022.822847.s002
DOI:
10.3389/fmed.2022.822847.s003
DOI:
10.3389/fmed.2022.822847.s004
DOI:
10.3389/fmed.2022.822847.s005
DOI:
10.3389/fmed.2022.822847.s006
DOI:
10.3389/fmed.2022.822847.s007
DOI:
10.3389/fmed.2022.822847.s008
DOI:
10.3389/fmed.2022.822847.s009
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2775999-4
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