In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 8 ( 2022-8-22), p. e0273116-
Abstract:
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EAGLE consortium. The SNP heritability of total psychiatric problems was 5.4% (SE = 0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of SBF2 , a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total score were shared with common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (rG 〉 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG 〈 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation with intelligence, educational attainment, wellbeing, smoking, and body fat (rG 〉 0.29). The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between related traits.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0273116
DOI:
10.1371/journal.pone.0273116.g001
DOI:
10.1371/journal.pone.0273116.g002
DOI:
10.1371/journal.pone.0273116.t001
DOI:
10.1371/journal.pone.0273116.t002
DOI:
10.1371/journal.pone.0273116.t003
DOI:
10.1371/journal.pone.0273116.s001
DOI:
10.1371/journal.pone.0273116.s002
DOI:
10.1371/journal.pone.0273116.s003
DOI:
10.1371/journal.pone.0273116.s004
DOI:
10.1371/journal.pone.0273116.s005
DOI:
10.1371/journal.pone.0273116.s006
DOI:
10.1371/journal.pone.0273116.s007
DOI:
10.1371/journal.pone.0273116.s008
DOI:
10.1371/journal.pone.0273116.s009
DOI:
10.1371/journal.pone.0273116.s010
DOI:
10.1371/journal.pone.0273116.s011
DOI:
10.1371/journal.pone.0273116.s012
DOI:
10.1371/journal.pone.0273116.s013
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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