In:
Acta Anaesthesiologica Scandinavica, Wiley, Vol. 50, No. 5 ( 2006-05), p. 586-592
Abstract:
Background: This study was undertaken to investigate the effect of a small dose of perfluorocarbon on the recruitment pressure needed to open atelectatic lung areas. Methods: In 12 Yorkshire pigs (body weight, 9 kg), lung injury was induced by whole lung lavage. After 1 h of conventional ventilation, an open lung maneuver was performed to obtain P a o 2 values equal to the pre‐lavage P a o 2 values (±10%). After 1 h of ventilation at the lowest possible airway pressure that stabilized the recruited lung volume, the animals were disconnected from the ventilator to allow the lung to collapse. Six animals received a 5 ml/kg intratracheal dose of perfluorocarbon and a second open lung maneuver was performed. Six animals served as controls and received no perfluorocarbon but also underwent a second open lung maneuver. Results: In both groups, an open lung maneuver resulted in a significant increase in oxygenation. The peak pressures needed to open the lung after 1 h of mechanical ventilation in the perfluorocarbon and control groups were 43.8 ± 8.4 cmH 2 O and 46.6 ± 4 cmH 2 O, respectively. The addition of perfluorocarbon significantly reduced the opening pressure to 34.5 ± 6.3 cmH 2 O ( P 〈 0.01), whereas the opening pressure in the control group, 45.0 ± 0.2 cmH 2 O, did not change. Conclusion: The instillation of a small amount of perfluorocarbon significantly reduces the opening pressures needed to recruit atelectatic lung areas.
Type of Medium:
Online Resource
ISSN:
0001-5172
,
1399-6576
DOI:
10.1111/aas.2006.50.issue-5
DOI:
10.1111/j.1399-6576.2006.001007.x
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
2004319-3
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