In:
Annals of Nutrition and Metabolism, S. Karger AG, Vol. 76, No. 3 ( 2020), p. 165-174
Abstract:
〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 To explore trimester-specific thyroid function changes under different iodine statuses throughout pregnancy. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A cross-sectional study was conducted to assess the pregnancy iodine status, and 2,378 healthy pregnant women covering all 3 trimesters were recruited. Urinary iodine concentration (UIC) was measured by collecting spot urine samples. Blood samples were collected to evaluate thyroid function. Thyroid B-ultrasonography was conducted to measure the thyroid volume (Tvol). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The median UIC was 168 μg/L (111–263 μg/L). The UIC, free triiodothyronine (FT3), and free thyroxine (FT4) were significantly decreased as the pregnancy progressed ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001, 〈 i 〉 p 〈 /i 〉 for trend & #x3c;0.001), while Tvol increased ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001, 〈 i 〉 p 〈 /i 〉 for trend & #x3c;0.001). Thyrotropin (TSH) was significantly different between the 3 trimesters and showed an upward trend ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), but the 〈 i 〉 p 〈 /i 〉 for trend was not significant ( 〈 i 〉 p 〈 /i 〉 for trend = 0.88). After stratification by UIC, there were no significant differences in serum TSH, FT4, or FT3 level between UIC groups. Tvol was significantly higher in the UIC ≥500 μg/L group in the first trimester (β: 2.41, 95% CI: 1.09–3.72, 〈 i 〉 p 〈 /i 〉 & #x3c;0.001), as well as in the 250 ≤ UIC & #x3c; 500 μg/L group (β: 1.65, 95% CI: 0.61–2.70, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001) and UIC ≥500 μg/L group (β: 3.35, 95% CI: 1.96–4.74, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001) in the third trimester. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 No difference was observed in TSH, FT3, or FT4 among the different iodine status groups throughout pregnancy. Tvol increased as the pregnancy progressed, and it was especially higher in the UIC ≥500 μg/L group in the first and third trimesters.
Type of Medium:
Online Resource
ISSN:
0250-6807
,
1421-9697
Language:
English
Publisher:
S. Karger AG
Publication Date:
2020
detail.hit.zdb_id:
1481977-6
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