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  • 1
    Online Resource
    Online Resource
    Early repolarization is associated with a significantly increased risk of ventricular arrhythmias and sudden cardiac death in patients with structural heart diseases
    Elsevier BV ; 2017
    In:  Heart Rhythm Vol. 14, No. 8 ( 2017-08), p. 1157-1164
    Details
    In: Heart Rhythm, Elsevier BV, Vol. 14, No. 8 ( 2017-08), p. 1157-1164
    Type of Medium: Online Resource
    ISSN: 1547-5271
    URL: Article
    DOI: 10.1016/j.hrthm.2017.04.022
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
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  • 2
    Online Resource
    Online Resource
    SCN 1Bβ mutations that affect their association with Kv4.3 underlie early repolarization syndrome
    Wiley ; 2018
    In:  Journal of Cellular and Molecular Medicine Vol. 22, No. 11 ( 2018-11), p. 5639-5647
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 22, No. 11 ( 2018-11), p. 5639-5647
    Abstract: Abnormal cardiac ion channels current, including transient outward potassium current (I to ), is associated with early repolarization syndrome ( ERS ). Previous studies showed that mutations in SCN 1Bβ both to increase the I to current and to decrease the sodium current. Yet its role in ERS remains unknown. Objective To determine the role of mutations in the SCN 1Bβ subunits in ERS . Methods We screened for mutations in the SCN 1B genes from four families with ERS . Wild‐type and mutant SCN 1Bβ genes were co‐expressed with wild‐type KCND 3 in human embryonic kidney cells ( HEK 293). Whole‐cell patch‐clamp technique and co‐immunoprecipitation were used to study the electrophysiological properties and explore the underlying mechanisms. Results S248R and R250T mutations in SCN 1Bβ were detected in 4 families’ probands. Neither S248R nor R250T mutation had significant influence on the sodium channel current density ( I N a ) when co‐expressed with SCN 5A/ WT . Co‐expression of KCND 3/ WT and SCN 1Bβ/S248R or SCN 1Bβ/R250T increased the transient outward potassium current I to by 27.44% and 199.89%, respectively ( P  〈   0.05 and P  〈   0.01, respectively) when compared with SCN 1Bβ/ WT . Electrophysiological properties showed that S248R and R250T mutations decreased the steady‐state inactivation and recovery from inactivation of I to channel. Co‐immunoprecipitation study demonstrated an increased association between SCN 1Bβ mutations and Kv4.3 compared with SCN 1Bβ/ WT ( P  〈   0.05 and P  〈   0.01, respectively). Conclusion The S248R and R250T mutations of SCN 1Bβ gene caused gain‐of‐function of I to by associated with Kv4.3, which maybe underlie the ERS phenotype of the probands.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.2018.22.issue-11
    DOI: 10.1111/jcmm.13839
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2076114-4
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  • 3
    Online Resource
    Online Resource
    Role of Early Repolarization Pattern in Increasing Risk of Death
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Journal of the American Heart Association Vol. 5, No. 9 ( 2016-09)
    Details
    In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 5, No. 9 ( 2016-09)
    Abstract: An early repolarization pattern ( ERP ) has been hypothesized to be arrhythmogenic in experimental studies, but the prognostic significance of the ERP in the general population is controversial. We performed a meta‐analysis to examine the link between ERP and the risk of sudden cardiac arrest ( SCA ), cardiac death, and death from any cause. Methods and Results We performed a literature search using MEDLINE (January 1, 1966 to July 31, 2015) and EMBASE (January 1, 1980 to July 31, 2015) with no restrictions. Studies that reported relative risk ( RR ) estimates with 95% confidence intervals ( CI s) for the associations of interest were included. Sixteen studies involving 334 524 subjects were identified. Compared with those without ERP , subjects with ERP experienced significantly increased risk for developing SCA ( RR 2.18; 95% CI 1.29–3.68), cardiac death ( RR 1.48; 95% CI 1.06–2.07), and death from any cause ( RR 1.21; 95% CI 1.02–1.42), respectively. The increased risk was present predominantly in Asians and whites but not in African Americans. ERP with J‐point elevation in inferior leads, notching configuration, and horizontal or descending ST segment connote higher risk. ERP was associated with an absolute risk increase of 139.6 (95% CI 130.3–149.3) additional SCA s per 100 000 person‐years and responsible for 7.3% (95% CI 1.9–15.2) of SCA in the general population. Conclusions ERP is associated with significant increased risk for SCA , cardiac death, and death from any cause. Future studies should focus on understanding the exact mechanisms for the arrhythmia risk and developing reliable tools for risk stratification.
    Type of Medium: Online Resource
    ISSN: 2047-9980
    URL: Article
    DOI: 10.1161/JAHA.116.003375
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
    detail.hit.zdb_id: 2653953-6
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  • 4
    Online Resource
    Online Resource
    A Heterozygous Missense hERG Mutation Associated with Early Repolarization Syndrome
    S. Karger AG ; 2018
    In:  Cellular Physiology and Biochemistry Vol. 51, No. 3 ( 2018), p. 1301-1312
    Details
    In: Cellular Physiology and Biochemistry, S. Karger AG, Vol. 51, No. 3 ( 2018), p. 1301-1312
    Abstract: Background/Aims: Early repolarization syndrome (ERS) has been recently recognized as early repolarization pattern with idiopathic ventricular fibrillation. However, the genetic background of ERS has not been fully understood. Methods: A Chinese family with sudden cardiac death associated with ERS was investigated. Direct sequencing of ERS susceptibility genes was performed on the proband and family members. Whole-cell patch-clamp methods were used to characterize the mutant channel expressed in HEK 293 cells. Results: One missense mutation (p. K801T) was found in the hERG (KCNH2 gene) by the direct sequencing of candidate genes. Whole cell voltage clamp studies of the K801T mutation in HEK 293 cells demonstrated a 1.5-fold increase in maximum steady state current (37.2±7.3 vs 20.3±4.4 pA/pF) that occurred at a 20 mV more positive potential compared to the wild type channels. The voltage dependence of inactivation was significantly shifted in the positive voltage direction (WT -59.5±1.4 vs K801T -44.3±1.2 mV). Kinetic analysis revealed slower inactivation rates of K801T, but faster rates of activation and deactivation. The hERG channel blockers tested inhibited K801T-hERG channel in concentration response, and the potencies of these drugs can be rank-ordered as follows: quinidine 〉 disopyramide 〉 sotalol 〉 flecainide. Conclusion: Our study indicated that the K801T mutation caused the gain of function of hERG channels that may account for the clinical phenotype of ERS. Quinidine and disopyramide could improve the function of K801T-hERG mutant channel, and may be therapeutic options for patients with the K801T hERG mutation.
    Type of Medium: Online Resource
    ISSN: 1015-8987 , 1421-9778
    URL: Article
    DOI: 10.1159/000495549
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1482056-0
    SSG: 12
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    Long‐Term Cardiovascular Risk After Radiotherapy in Women With Breast Cancer
    Ovid Technologies (Wolters Kluwer Health) ; 2017
    In:  Journal of the American Heart Association Vol. 6, No. 5 ( 2017-05-05)
    Details
    In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 6, No. 5 ( 2017-05-05)
    Abstract: Radiotherapy for breast cancer often involves some incidental exposure of the heart to ionizing radiation. The effect of this exposure on the subsequent risk of heart disease is uncertain. We performed a meta‐analysis to investigate the link between radiotherapy and long‐term cardiovascular morbidity and mortality in patients with breast cancer. Methods and Results We performed a literature search using MEDLINE (January 1966 to January 2015) and EMBASE (January 1980 to January 2015) with no restrictions. Studies that reported relative risk ( RR ) estimates with 95% CI s for the associations of interest were included. Pooled effect estimates were obtained by using random‐effects meta‐analysis. Thirty‐nine studies involving 1 191 371 participants were identified. Patients who received left‐sided radiotherapy, as compared with those receiving right‐sided radiotherapy, experienced increased risks of developing coronary heart disease ( RR 1.29, 95% CI 1.13‐1.48), cardiac death ( RR 1.22, 95% CI 1.08‐1.37) and death from any cause ( RR 1.05, 95% CI 1.01‐1.10). In a comparison of patients with radiotherapy and without radiotherapy, the RR s were 1.30 (95% CI 1.13‐1.49) for coronary heart disease and 1.38 (95% CI 1.18‐1.62) for cardiac mortality. Radiotherapy for breast cancer was associated with an absolute risk increase of 76.4 (95% CI 36.8‐130.5) cases of coronary heart disease and 125.5 (95% CI 98.8‐157.9) cases of cardiac death per 100 000 person‐years. The risk started to increase within the first decade for coronary heart disease and from the second decade for cardiac mortality. Conclusions Exposure of the heart to ionizing radiation during radiotherapy for breast cancer increases the subsequent risk of coronary heart disease and cardiac mortality.
    Type of Medium: Online Resource
    ISSN: 2047-9980
    URL: Article
    DOI: 10.1161/JAHA.117.005633
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
    detail.hit.zdb_id: 2653953-6
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  • 6
    Online Resource
    Online Resource
    Long-term prognosis associated with early repolarisation pattern in Chinese population with atherosclerotic risk factors
    BMJ ; 2017
    In:  Heart Vol. 103, No. 12 ( 2017-06), p. 910-916
    Details
    In: Heart, BMJ, Vol. 103, No. 12 ( 2017-06), p. 910-916
    Type of Medium: Online Resource
    ISSN: 1355-6037 , 1468-201X
    URL: Article
    DOI: 10.1136/heartjnl-2016-310259
    Language: English
    Publisher: BMJ
    Publication Date: 2017
    detail.hit.zdb_id: 2378689-9
    detail.hit.zdb_id: 1475501-4
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  • 7
    Online Resource
    Online Resource
    Image_2.tif
    Frontiers Media SA ; 2021
    In:  Frontiers in Immunology Vol. 12 ( 2021-11-18)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 12 ( 2021-11-18)
    Abstract: Norovirus (NoV) is a zoonotic virus that causes diarrhea in humans and animals. Outbreaks in nosocomial settings occur annually worldwide, endangering public health and causing serious social and economic burdens. The latter quarter of 2016 witnessed the emergence of the GII.P16-GII.2 recombinant norovirus throughout Asia. This genotype exhibits strong infectivity and replication characteristics, proposing its potential to initiate a pandemic. There is no vaccine against GII.P16-GII.2 recombinant norovirus, so it is necessary to design a preventive vaccine. In this study, GII.P16-GII.2 type norovirus virus-like particles (VLPs) were constructed using the baculovirus expression system and used to conduct immunizations in mice. After immunization of mice, mice were induced to produce memory T cells and specific antibodies, indicating that the VLPs induced specific cellular and humoral immune responses. Further experiments were then initiated to understand the underlying mechanisms involved in antigen presentation. Towards this, we established co-cultures between dendritic cells (DCs) or macrophages (Mø) and naïve CD4+T cells and simulated the antigen presentation process by incubation with VLPs. Thereafter, we detected changes in cell surface molecules, cytokines and related proteins. The results indicated that VLPs effectively promoted the phenotypic maturation of Mø but not DCs, as indicated by significant changes in the expression of MHC-II, costimulatory factors and related cytokines in Mø. Moreover, we found VLPs caused Mø to polarize to the M1 type and release inflammatory cytokines, thereby inducing naïve CD4+ T cells to perform Th1 immune responses. Therefore, this study reveals the mechanism of antigen presentation involving GII.P16-GII.2 recombinant norovirus VLPs, providing a theoretical basis for both understanding responses to norovirus infection as well as opportunities for vaccine development.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fimmu.2021.781718
    DOI: 10.3389/fimmu.2021.781718.s001
    DOI: 10.3389/fimmu.2021.781718.s002
    DOI: 10.3389/fimmu.2021.781718.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2606827-8
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  • 8
    Online Resource
    Online Resource
    Discovery and identification of serum potential biomarkers for pulmonary tuberculosis using iTRAQ‐coupled two‐dimensional LC‐MS/MS
    Wiley ; 2014
    In:  PROTEOMICS Vol. 14, No. 2-3 ( 2014-02), p. 322-331
    Details
    In: PROTEOMICS, Wiley, Vol. 14, No. 2-3 ( 2014-02), p. 322-331
    Abstract: Pulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis is a chronic disease. Currently, there are no sufficiently validated biomarkers for early diagnosis of TB infection. In this study, a panel of potential serum biomarkers was identified between patients with pulmonary TB and healthy controls by using iTRAQ‐coupled 2D LC‐MS/MS technique. Among 100 differentially expressed proteins screened, 45 proteins were upregulated ( 〉 1.25‐fold at p 〈 0.05) and 55 proteins were downregulated ( 〈 0.8‐fold at p 〈 0.05) in the TB serum. Bioinformatics analysis revealed that the differentially expressed proteins were related to the response to stimulus, the metabolic and immune system processes. The significantly differential expression of apolipoprotein CII (APOCII), CD5 antigen‐like (CD5L), hyaluronan‐binding protein 2 (HABP2), and retinol‐binding protein 4 (RBP4) was further confirmed using immunoblotting and ELISA analysis. By forward stepwise multivariate regression analysis, a panel of serum biomarkers including APOCII, CD5L, and RBP4 was obtained to form the disease diagnostic model. The receiver operation characteristic curve of the diagnostic model was 0.98 (sensitivity = 93.42%, specificity = 92.86%). In conclusion, APOCII, CD5L, HABP2, and RBP4 may be potential protein biomarkers of pulmonary TB. Our research provides useful data for early diagnosis of TB.
    Type of Medium: Online Resource
    ISSN: 1615-9853 , 1615-9861
    URL: Issue
    URL: Article
    DOI: 10.1002/pmic.v14.2-3
    DOI: 10.1002/pmic.201300383
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2037674-1
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Serum complement C4b, fibronectin, and prolidase are associated with the pathological changes of pulmonary tuberculosis
    Springer Science and Business Media LLC ; 2014
    In:  BMC Infectious Diseases Vol. 14, No. 1 ( 2014-12)
    Details
    In: BMC Infectious Diseases, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2014-12)
    Abstract: Mycobacterium tuberculosis infection can activate the immune system, leading to characteristic pathological changes such as inflammatory granuloma, caseous necrosis, and cavity formation. Methods Clinical data of 187 cases of pulmonary tuberculosis (PTB) were analyzed using statistical methods, while serum levels of complement C4b (C4b), fibronectin (FN), and prolidase (PEPD) were detected using the ELISA method among the control, minimal PTB, moderate PTB, and advanced PTB groups. Results We found significantly higher levels of serum C4b and PEPD ( P  = 0.018, P  = 0.003), and significantly lower levels of serum FN ( P   〈  0.001) in PTB patients. Furthermore, the serum levels of 3 proteins were significantly different among 3 PTB groups. FN level was significantly higher in the moderate PTB group, compared with patients in the minimal and advanced PTB groups ( P   〈  0.05, P   〈  0.01). PEPD level was significantly higher in the moderate PTB group, compared with the minimal PTB group ( P   〈  0.05). Analysis of clinical data showed that serum albumin, C-reactive protein (CRP), prealbumin, and C4 were significantly higher ( P   〈  0.05), while serum globulin was significantly lower in patients with PTB ( P   〈  0.001). A significant negative correlation was found between C4b and albumin, prealbumin. On the other hand, a significant positive correlation was found between C4b and globulin, CRP, PEPD, as well as between PEPD and CRP ( P   〈  0.05). Conclusions Our study showed that C4b, FN, and PEPD are associated with tissue damage, granuloma formation, and cavity formation, respectively, in patients with PTB. The present study provides a new experimental basis to understand the pathogenesis and pathological changes of PTB.
    Type of Medium: Online Resource
    ISSN: 1471-2334
    URL: Article
    DOI: 10.1186/1471-2334-14-52
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2014
    detail.hit.zdb_id: 2041550-3
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  • 10
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    Serum protein S100A9, SOD3, and MMP9 as new diagnostic biomarkers for pulmonary tuberculosis by iTRAQ‐coupled two‐dimensional LC‐MS/MS
    Wiley ; 2015
    In:  PROTEOMICS Vol. 15, No. 1 ( 2015-01), p. 58-67
    Details
    In: PROTEOMICS, Wiley, Vol. 15, No. 1 ( 2015-01), p. 58-67
    Abstract: This study aimed to discover the novel noninvasive biomarkers for the diagnosis of pulmonary tuberculosis (TB). We applied iTRAQ 2D LC‐MS/MS technique to investigate protein profiles in patients with pulmonary TB and other lung diseases. A total of 34 differentially expressed proteins (24 upregulated proteins and ten downregulated proteins) were identified in the serum of pulmonary TB patients. Significant differences in protein S100‐A9 (S100A9), extracellular superoxide dismutase [Cu‐Zn] (SOD3), and matrix metalloproteinase 9 (MMP9) were found between pulmonary TB and other lung diseases by ELISA. Correlations analysis revealed that the serum concentration of MMP9 in the pulmonary TB was in moderate correlation with SOD3 ( r = 0.581) and S100A9 ( r = 0.471), while SOD3 was in weak correlation with S100A9 ( r = 0.287). The combination of serum S100A9, SOD3, and MMP9 levels could achieve 92.5% sensitivity and 95% specificity to discriminate between pulmonary TB and healthy controls, 90% sensitivity and 87.5% specificity to discriminate between pulmonary TB and pneumonia, and 85% sensitivity and 92.5% specificity to discriminate between pulmonary TB and lung cancer, respectively. The results showed that S100A9, SOD3, and MMP9 may be potential diagnostic biomarkers for pulmonary TB, and provided experimental basis for the diagnosis of pulmonary TB.
    Type of Medium: Online Resource
    ISSN: 1615-9853 , 1615-9861
    URL: Issue
    URL: Article
    DOI: 10.1002/pmic.v15.1
    DOI: 10.1002/pmic.201400366
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2037674-1
    SSG: 12
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