In:
British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 190, No. 4 ( 2007-04), p. 357-358
Abstract:
Hypothalamic–pituitary–adrenal (HPA) axis sensitivity was investigated in 32 non-medicated patients with borderline personality disorder without comorbid post-traumatic syndromes and in 18 normal individuals using a modified dexamethasone suppression test (0.25 mg). Enhanced cortisol suppression was found in the patients v. controls ( P 〈 0.05) and the percentage of participant's with non-suppression was smaller in the patient (34%) than in the control group (89%) ( P 〈 0.01). Baseline cortisol levels in the patients were also lower than in the controls ( P 〈 0.05). The 0.25 mg dexamethasone suppression test reveals increased feedback inhibition of the HPA in borderline personality disorder.
Type of Medium:
Online Resource
ISSN:
0007-1250
,
1472-1465
DOI:
10.1192/bjp.bp.106.022590
Language:
English
Publisher:
Royal College of Psychiatrists
Publication Date:
2007
detail.hit.zdb_id:
2021500-9
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