In:
Nephron, S. Karger AG, Vol. 147, No. 9 ( 2023), p. 521-530
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The association between potassium (sK) level trajectory and mortality or the need for kidney replacement therapy (KRT) during acute kidney injury (AKI) has not been adequately explored. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In this prospective cohort, AKI patients admitted to the Hospital Civil de Guadalajara were enrolled. Eight groups based on the sK (mEq/L) level trajectories during 10 days of hospitalization were created (1) normokalemia (normoK), defined as sK between 3.5–5.5; (2) hyperkalemia to normoK; (3) hypokalemia to normoK; (4) fluctuating potassium; (5) persistent hypoK; (6) normoK to hypoK; (7) normoK to hyperK; (8) persistent hyperK. We assessed the association of sK trajectories with mortality and the need for KRT. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A total of 311 AKI patients were included. The mean age was 52.6 years, and 58.6% were male. AKI stage 3 was present in 63.9%. KRT started in 36% patients, and 21.2% died. After adjusting for confounders, 10-day hospital mortality was significantly higher in groups 7 and 8 (OR, 1.35 and 1.61, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.05, for both, respectively), and KRT initiation was higher only in group 8 (OR 1.38, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.05) compared with group 1. Mortality in different subgroups of patients in group 8 did not change the primary results. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 In our prospective cohort, most patients with AKI had alterations in sK 〈 sup 〉 + 〈 /sup 〉 . NormoK to hyperK and persistent hyperK were associated with death, while only persistent hyperK was correlated with the need for KRT.
Type of Medium:
Online Resource
ISSN:
1660-8151
,
2235-3186
Language:
English
Publisher:
S. Karger AG
Publication Date:
2023
detail.hit.zdb_id:
2810853-X
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