In:
PLOS ONE, Public Library of Science (PLoS), Vol. 19, No. 5 ( 2024-5-9), p. e0302628-
Abstract:
Blood vessels permit the selective passage of molecules and immune cells between tissues and circulation. Uncontrolled inflammatory responses from an infection can increase vascular permeability and edema, which can occasionally lead to fatal organ failure. We identified mexenone as a vascular permeability blocker by testing 2,910 compounds in the Clinically Applied Compound Library using the lipopolysaccharide (LPS)-induced vascular permeability assay. Mexenone suppressed the LPS-induced downregulation of junctional proteins and phosphorylation of VE-cadherin in Bovine Aortic Endothelial Cells (BAECs). The injection of mexenone 1 hr before LPS administration completely blocked LPS-induced lung vascular permeability and acute lung injury in mice after 18hr. Our results suggest that mexenone-induced endothelial cell (EC) barrier stabilization could be effective in treating sepsis patients.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0302628
DOI:
10.1371/journal.pone.0302628.g001
DOI:
10.1371/journal.pone.0302628.g002
DOI:
10.1371/journal.pone.0302628.g003
DOI:
10.1371/journal.pone.0302628.g004
DOI:
10.1371/journal.pone.0302628.t001
DOI:
10.1371/journal.pone.0302628.s001
DOI:
10.1371/journal.pone.0302628.s002
DOI:
10.1371/journal.pone.0302628.s003
DOI:
10.1371/journal.pone.0302628.s004
DOI:
10.1371/journal.pone.0302628.s005
DOI:
10.1371/journal.pone.0302628.s006
DOI:
10.1371/journal.pone.0302628.s007
DOI:
10.1371/journal.pone.0302628.s008
DOI:
10.1371/journal.pone.0302628.r001
DOI:
10.1371/journal.pone.0302628.r002
DOI:
10.1371/journal.pone.0302628.r003
DOI:
10.1371/journal.pone.0302628.r004
DOI:
10.1371/journal.pone.0302628.r005
DOI:
10.1371/journal.pone.0302628.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2024
detail.hit.zdb_id:
2267670-3
Permalink