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  • 1
    Online Resource
    Online Resource
    High Erythrocyte Sedimentation Rate is Associated with White Matter Hyperintensity in a Healthy Population
    Korean Society of Neurosonology ; 2021
    In:  Journal of Neurosonology and Neuroimaging Vol. 13, No. 1 ( 2021-06-30), p. 7-13
    Details
    In: Journal of Neurosonology and Neuroimaging, Korean Society of Neurosonology, Vol. 13, No. 1 ( 2021-06-30), p. 7-13
    Type of Medium: Online Resource
    ISSN: 2635-425X , 2635-4357
    URL: Article
    DOI: 10.31728/jnn.2021.00098
    Language: English
    Publisher: Korean Society of Neurosonology
    Publication Date: 2021
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  • 2
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    Intracranial Atherosclerosis and Stage 1 Hypertension Defined by the 2017 ACC/AHA Guideline
    Oxford University Press (OUP) ; 2020
    In:  American Journal of Hypertension Vol. 33, No. 1 ( 2020-01-01), p. 92-98
    Details
    In: American Journal of Hypertension, Oxford University Press (OUP), Vol. 33, No. 1 ( 2020-01-01), p. 92-98
    Abstract: In 2017, the American College of Cardiology (ACC)/American Heart Association (AHA) released a new, stricter definition of stage 1 hypertension which was previously considered prehypertension. However, impacts of the novel stage 1 hypertension on deleterious target-organ outcomes are still controversial. In this study, we evaluated the relationship between this newly defined stage 1 hypertension and the presence of intracranial atherosclerosis (ICAS) lesions in neurologically healthy participants. Methods We assessed consecutive participants in routine health checkups between January 2006 and December 2013. Blood pressure (BP) was classified according to the 2017 ACC/AHA hypertension guideline, and ICAS was defined as occlusion or ≥50% stenosis of intracranial vessels on flight magnetic resonance angiography. Results Among 3,111 healthy participants (mean age: 56 years, sex: 54% men), 85 (3%) had ICAS lesions. In multivariate analysis, stage 1 hypertension (adjusted odds ratio: 2.46, 95% confidence interval: 1.10–5.51, P = 0.029) remained an independent predictor of ICAS after adjustment for confounders. Stage 2 hypertension showed a higher odds ratio and a lower P value, indicating a dose–response effect. Age and HbA1c level were also significantly associated with ICAS, independent of the BP categories. The ICAS lesion burden showed a dose–response effect across the BP categories (P for trend & lt;0.001), whereas ICAS lesion location did not (P for trend = 0.699). Conclusions We demonstrated that stage 1 hypertension, defined according to the 2017 ACC/AHA guideline, was associated with a higher prevalence and burden of ICAS lesions in a neurologically healthy population.
    Type of Medium: Online Resource
    ISSN: 0895-7061 , 1941-7225
    URL: Article
    DOI: 10.1093/ajh/hpz138
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 1479505-X
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  • 3
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    Impact of number of medications and age on adherence to antihypertensive medications : A nationwide population-based study
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Medicine Vol. 98, No. 49 ( 2019-12), p. e17825-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 98, No. 49 ( 2019-12), p. e17825-
    Abstract: This study tried to investigate the effects of number of medications and age on antihypertensive medication adherence in a real-world setting using a nationwide representative cohort. We obtained data from the National Health Insurance Service-National Sample Cohort (NHIS-NSC) of Korea, which is a sample of 2.2% (N = 1,048,061) of total population (N = 46,605,433). Patients aged 20 years or older (N = 150,550) who took antihypertensive medications for at least 1 year were selected. Medication possession ratio (MPR) was used for measuring adherence. The subjects were divided into 5 subgroups according to total number of medications: 1–2, 3–4, 5–6, 7–8, and 9 or more. The mean age and the mean number of medications were 60.3 ± 12.6 years and 4.1 ± 2.2, respectively. The mean MPR was 80.4 ± 23.9%, and 66.9% (N = 100,645) of total subjects were adherent (MPR ≥ 80%). The overall tendency of antihypertensive medication adherence according to the total number of medications displayed an inverted U-shape with a peak at 3–4 drugs. Adherence consistently increased as the age increased until age 69 and started to decrease from age 70. The proportion of adherent patients (MPR ≥ 80%) according to the total number of medications also showed an inverted U-shape with a peak at 3–4 drugs. When the same number of drugs was taken, the proportion of adherent patients according to age featured an inverted U- shape with a peak at 60 to 69 years. Patients taking 9 or more total drugs had the overall odds ratio (95% CI) of non-adherence (MPR  〈  80%) with 1.17 (1.11–1.24) compared with those taking 1 to 8 total drugs and the odds ratios in the age subgroups of 40 to 49, 50 to 59, 60 to 69 years were 1.57 (1.31–1.87), 1.21 (1.08–1.36), and 1.14 (1.04–1.25), respectively ( P   〈  .05). Association between age, total number of medications, and antihypertensive adherence displayed an inverted U-shape with a peak at 3 to 4 total medications and at age 60 to 69 years. When the total number of drugs was 9 or more, adherence decreased prominently, regardless of age.
    Type of Medium: Online Resource
    ISSN: 0025-7974 , 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000017825
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2049818-4
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  • 4
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    Abstract TP191: Serum Homocysteine Level is Associated With Cerebral Small Vessel Disease in a Healthy Population
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Stroke Vol. 50, No. Suppl_1 ( 2019-02)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 50, No. Suppl_1 ( 2019-02)
    Abstract: Objective: To evaluate the relationship between serum homocysteine (Hcy) levels and cerebral small vessel disease (cSVD) in a healthy population. Methods: We included consecutive subjects who visited our department for health check-ups between 2006 and 2013. We rated white matter hyperintensity (WMH) volumes using both the Fazekas score and semi-automated quantitative methods. We also evaluated lacunes, cerebral microbleeds (CMBs), and enlarged perivascular spaces (EPVSs) which are involved in cSVD. To assess the dose-dependent relationship between Hcy and cSVD parameters, wescored the burdens of each radiological marker of cSVD. Results: A total of 1,578 subjects were included (median WMH volume: 1.00 mL; frequencies of lacunes, CMBs, and moderate-to-severe EPVS: 4%, 7%, and 39%, respectively). In the multivariate analysis, Hcy remained a significant predictor of the WMH volume (B = 0.209; 95% confidence interval [CI] = 0.033 to 0.385, P = 0.020), presence of CMBs (adjusted odds ratio [aOR] = 2.800; 95% CI = 1.104 to 7.105, P = 0.030), and moderate-to-severe EPVSs (aOR = 5.906; 95% CI = 3.523 to 9.901, P 〈 0.001) after adjusting for confounders. Furthermore, Hcy had positive associations with periventricularFazekas score (P = 0.001, P for trend 〈 0.001), subcortical Fazekas score (P = 0.003, P for trend = 0.005), and moderate-to-severe EPVS lesion burden (P 〈 0.001, P for trend 〈 0.001) in a dose-dependent manner. Conclusions: Elevated Hcy level is correlated with cSVD development in a dose-dependent manner. These findings provide us with clues for further studies of the pathophysiology of cSVD.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.50.suppl_1.TP191
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 1467823-8
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  • 5
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    Vascular Overload Index Predicts Cerebral Small Vessel Disease in a Neurologically Healthy Population
    Korean Society of Neurosonology ; 2021
    In:  Journal of Neurosonology and Neuroimaging Vol. 13, No. 2 ( 2021-12-31), p. 55-63
    Details
    In: Journal of Neurosonology and Neuroimaging, Korean Society of Neurosonology, Vol. 13, No. 2 ( 2021-12-31), p. 55-63
    Abstract: Background: Arterial stiffness has been suggested as one of the major pathological mechanisms of cerebral small vessel diseases (cSVDs). In this study, we confirmed this hypothesis by evaluating the association between vascular overload index (VOI), which is a physiologically good indicator of arterial stiffness, and cSVD.Methods: We evaluated participants who visited Seoul National University Hospital Health Promotion Center for health check-ups between 2006 and 2013. VOI was calculated by the following formula: VOI (mmHg)=1.33×systolic blood pressure -0.33×diastolic blood pressure-133.3. cSVDs were measured including white matter hyperintensity (WMH), lacunes, and cerebral microbleeds (CMBs). We quantitatively measured the WMH volume and rated the presence and number of lacunes and CMBs qualitatively.Results: A total of 3,231 participants were evaluated (mean age 57±9 years, male sex 53.9%). In multivariable linear regression analysis, VOI was significantly associated with WMH volume after adjusting confounders (β=0.004, 95% confidence interval=0.002–0.006). VOI also showed a close association with lacunes in multivariable logistic regression analysis (adjusted odds ratio=1.01, 95% confidence interval=1.00–1.02). There was no statistical association with CMBs. In subgroup analysis according to the presence of hypertension, VOI was closely associated with WMH volume/lacunes only in patients without hypertension. In patients with hypertension, these statistical associations disappeared.Conclusion: A high VOI was associated with cSVD in a neurologically healthy population, especially in patients without hypertension. This marker of arterial stiffness could be convenient and useful predictor of cSVD.
    Type of Medium: Online Resource
    ISSN: 2635-425X , 2635-4357
    URL: Article
    DOI: 10.31728/jnn.2021.00105
    Language: English
    Publisher: Korean Society of Neurosonology
    Publication Date: 2021
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  • 6
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    Obesity without metabolic disorder and silent brain infarcts in a neurologically healthy population
    Springer Science and Business Media LLC ; 2020
    In:  International Journal of Obesity Vol. 44, No. 2 ( 2020-02-01), p. 362-367
    Details
    In: International Journal of Obesity, Springer Science and Business Media LLC, Vol. 44, No. 2 ( 2020-02-01), p. 362-367
    Type of Medium: Online Resource
    ISSN: 0307-0565 , 1476-5497
    URL: Article
    DOI: 10.1038/s41366-019-0372-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2101927-7
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  • 7
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    Bifidobacterial probiotics protect mice from diet-induced obesity and fatty liver disease
    Springer Science and Business Media LLC ; 2022
    In:  Microbiome Vol. 10, No. 1 ( 2022-11-04)
    Details
    In: Microbiome, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2022-11-04)
    Abstract: Comparisons of the gut microbiome of lean and obese humans have revealed that obesity is associated with the gut microbiome plus changes in numerous environmental factors, including high-fat diet (HFD). Here, we report that two species of Bifidobacterium are crucial to controlling metabolic parameters in the Korean population. Results Based on gut microbial analysis from 99 Korean individuals, we observed the abundance of Bifidobacterium longum and Bifidobacterium bifidum was markedly reduced in individuals with increased visceral adipose tissue (VAT), body mass index (BMI), blood triglyceride (TG), and fatty liver. Bacterial transcriptomic analysis revealed that carbohydrate/nucleoside metabolic processes of Bifidobacterium longum and Bifidobacterium bifidum were associated with protecting against diet-induced obesity. Oral treatment of specific commercial Bifidobacterium longum and Bifidobacterium bifidum enhanced bile acid signaling contributing to potentiate oxidative phosphorylation (OXPHOS) in adipose tissues, leading to reduction of body weight gain and improvement in hepatic steatosis and glucose homeostasis. Bifidobacterium longum or Bifidobacterium bifidum manipulated intestinal sterol biosynthetic processes to protect against diet-induced obesity in germ-free mice. Conclusions Our findings support the notion that treatment of carbohydrate/nucleoside metabolic processes-enriched Bifidobacterium longum and Bifidobacterium bifidum would be a novel therapeutic strategy for reprograming the host metabolic homeostasis to protect against metabolic syndromes, including diet-induced obesity.
    Type of Medium: Online Resource
    ISSN: 2049-2618
    URL: Article
    URL: Article
    DOI: 10.1186/s40168-022-01374-0
    DOI: 10.21203/rs.3.rs-3250227/v1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2697425-3
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  • 8
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    Abdominal fatness and cerebral white matter hyperintensity
    Elsevier BV ; 2019
    In:  Journal of the Neurological Sciences Vol. 404 ( 2019-09), p. 52-57
    Details
    In: Journal of the Neurological Sciences, Elsevier BV, Vol. 404 ( 2019-09), p. 52-57
    Type of Medium: Online Resource
    ISSN: 0022-510X
    URL: Article
    DOI: 10.1016/j.jns.2019.07.016
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 1500645-1
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  • 9
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    Visceral adiposity index is associated with silent brain infarct in a healthy population
    Springer Science and Business Media LLC ; 2020
    In:  Scientific Reports Vol. 10, No. 1 ( 2020-10-14)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2020-10-14)
    Abstract: Visceral adiposity index (VAI) has been associated with various cardio-metabolic diseases; however, there is limited information about its association with cerebrovascular diseases. In this study, we evaluated the relationship between VAI and silent brain infarct (SBI). We evaluated a consecutive series of healthy volunteers over the age of 40 between January 2006 and December 2013. SBI was defined as an asymptomatic, well-defined lesion with a diameter ≥ 3 mm with the same signal characteristics as the cerebrospinal fluid. VAI was calculated using sex-specific equations as described in previous studies. A total of 2596 subjects were evaluated, and SBI was found in 218 (8%) participants. In multivariable analysis, VAI (adjusted odds ratio [aOR] = 1.30; 95% confidence interval [CI] 1.03–1.66; P  = 0.030) remained a significant predictor of SBI after adjustment for confounders. The close relationship between VAI and SBI was prominent only in females (aOR = 1.44; 95% CI 1.00–2.07; P  = 0.048). In the evaluation between VAI and the burden of SBI, VAI showed a positive dose–response relationship with the number of SBI lesions ( P for trend = 0.037). High VAI was associated with a higher prevalence and burden of SBI in a neurologically healthy population.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-020-74454-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2615211-3
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  • 10
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    Systemic immune-inflammation index is associated with white matter hyperintensity volume
    Springer Science and Business Media LLC ; 2022
    In:  Scientific Reports Vol. 12, No. 1 ( 2022-05-05)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-05-05)
    Abstract: Systemic immune-inflammation index (SII) is a novel inflammatory marker based on the composition ratio of blood cell counts. In this study, we evaluated the association between the SII and cerebral small vessel disease (cSVD) in health check-up participants. We evaluated participants from our health check-up registry between 2006 and 2013. The SII was calculated using the following formula: SII = (platelet count × neutrophil count)/lymphocyte count. cSVD was assessed by considering white matter hyperintensity (WMH) volume, lacunes, and cerebral microbleeds (CMBs). A total of 3187 participants were assessed. In multivariable linear regression analysis, the SII was significantly related to WMH volume [ β  = 0.120, 95% confidence interval (CI) 0.050–0.189]. However, lacunes and CMBs showed no statistical significance with the SII. In the subgroup analysis by age, the SII was significantly associated with WMH volume only in participants aged ≥ 60 years ( β  = 0.225, 95% CI 0.068–0.381). In conclusion, a high SII was associated with cSVD. Since this association was more pronounced in WMH than in lacunes or CMBs, WMH might be closer to the inflammation-related pathological mechanisms.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-022-11575-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2615211-3
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