In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 2 ( 2021-2-24), p. e0241114-
Abstract:
This study aimed to evaluate the association between intraoperative blood loss and myocardial injury after non-cardiac surgery (MINS), which is a severe and common postoperative complication. Methods We compared the incidence of MINS based on significant intraoperative bleeding, defined as an absolute hemoglobin level 〈 7 g/dL, a relative hemoglobin level less than 50% of the preoperative measurement, or need for packed red cell transfusion. We also estimated a threshold for intraoperative hemoglobin level associated with MINS. Results We stratified a total of 15,926 non-cardiac surgical patients with intraoperative hemoglobin and postoperative cardiac troponin (cTn) measurements according to the occurrence of significant intraoperative bleeding; 13,416 (84.2%) had no significant bleeding while 2,510 (15.8%) did have significant bleeding. After an adjustment with inverse probability weighting, the incidence of MINS was higher in the significant bleeding group (35.2% vs. 16.4%; odds ratio, 1.58; 95% confidence interval, 1.43–1.75; p 〈 0.001). The threshold of intraoperative hemoglobin associated with MINS was estimated to be 9.9 g/dL with an area under the curve of 0.643. Conclusion Intraoperative blood loss appeared to be associated with MINS. Further studies are needed to confirm these findings. Clinical registration The cohort was registered before patient enrollment at https://cris.nih.go.kr (KCT0004244).
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0241114
DOI:
10.1371/journal.pone.0241114.g001
DOI:
10.1371/journal.pone.0241114.g002
DOI:
10.1371/journal.pone.0241114.g003
DOI:
10.1371/journal.pone.0241114.t001
DOI:
10.1371/journal.pone.0241114.t002
DOI:
10.1371/journal.pone.0241114.t003
DOI:
10.1371/journal.pone.0241114.s001
DOI:
10.1371/journal.pone.0241114.s002
DOI:
10.1371/journal.pone.0241114.s003
DOI:
10.1371/journal.pone.0241114.s004
DOI:
10.1371/journal.pone.0241114.s005
DOI:
10.1371/journal.pone.0241114.s006
DOI:
10.1371/journal.pone.0241114.s007
DOI:
10.1371/journal.pone.0241114.s008
DOI:
10.1371/journal.pone.0241114.s009
DOI:
10.1371/journal.pone.0241114.r001
DOI:
10.1371/journal.pone.0241114.r002
DOI:
10.1371/journal.pone.0241114.r003
DOI:
10.1371/journal.pone.0241114.r004
DOI:
10.1371/journal.pone.0241114.r005
DOI:
10.1371/journal.pone.0241114.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
Permalink