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  • 1
    In: JNCI: Journal of the National Cancer Institute, Oxford University Press (OUP), Vol. 103, No. 16 ( 2011-08-17), p. 1236-1251
    Type of Medium: Online Resource
    ISSN: 1460-2105 , 0027-8874
    RVK:
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2011
    detail.hit.zdb_id: 2992-0
    detail.hit.zdb_id: 1465951-7
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  • 2
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2006
    In:  Canadian Journal of Anesthesia/Journal canadien d'anesthésie Vol. 53, No. 1 ( 2006-1), p. 26098-26098
    In: Canadian Journal of Anesthesia/Journal canadien d'anesthésie, Springer Science and Business Media LLC, Vol. 53, No. 1 ( 2006-1), p. 26098-26098
    Type of Medium: Online Resource
    ISSN: 0832-610X , 1496-8975
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2006
    detail.hit.zdb_id: 2050416-0
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  • 3
    Online Resource
    Online Resource
    Academy of Medicine, Singapore ; 2008
    In:  Annals of the Academy of Medicine, Singapore Vol. 36, No. 5 ( 2008-5-15), p. 319-325
    In: Annals of the Academy of Medicine, Singapore, Academy of Medicine, Singapore, Vol. 36, No. 5 ( 2008-5-15), p. 319-325
    Abstract: Introduction: Awake craniotomy allows accurate localisation of the eloquent brain, which is crucial during brain tumour resection in order to minimise risk of neurologic injury. The role of the anaesthesiologist is to provide adequate analgesia and sedation while maintaining ventilation and haemodynamic stability in an awake patient who needs to be cooperative during neurological testing. We reviewed the anaesthetic management of patients undergoing an awake craniotomy procedure. Materials and Methods: The records of all the patients who had an awake craniotomy at our institution from July 2004 till June 2006 were reviewed. The anaesthesia techniques and management were examined. The perioperative complications and the outcome of the patients were noted. Results: There were 17 procedures carried out during the study period. Local anaesthesia with moderate to deep sedation was the technique used in all the patients. Respiratory complications occurred in 24% of the patients. Hypertension was observed in 24% of the patients. All the complications were transient and easily treated. During cortical stimulation, motor function was assessed in 16 patients (94%). Three patients (16%) had lesions in the temporalparietal region and speech was assessed intraoperatively. Postoperative motor weakness was seen in 1 patient despite uneventful intraoperative testing. No patient required intensive care unit stay. The median length of stay in the high dependency unit was 1 day and the median length of hospital stay was 9 days. There was no in-hospital mortality. Conclusion: Awake craniotomy for brain tumour excision can be successfully performed under good anaesthetic conditions with careful titration of sedation. Our series showed it to be a well-tolerated procedure with a low rate of complications. The benefits of maximal tumour excision can be achieved, leading to potentially better patient outcome. Key words: Brain neoplasm, Neurosurgery, Postoperative complications
    Type of Medium: Online Resource
    ISSN: 0304-4602
    Language: English
    Publisher: Academy of Medicine, Singapore
    Publication Date: 2008
    detail.hit.zdb_id: 2186627-2
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  • 4
    Online Resource
    Online Resource
    Academy of Medicine, Singapore ; 2007
    In:  Annals of the Academy of Medicine, Singapore Vol. 36, No. 12 ( 2007-12-15), p. 987-994
    In: Annals of the Academy of Medicine, Singapore, Academy of Medicine, Singapore, Vol. 36, No. 12 ( 2007-12-15), p. 987-994
    Abstract: Introduction: Despite well-established guidelines, multiple recent studies have demonstrated variability in the conduct of brain death certification. This is undesirable given the gravity of the diagnosis. We sought therefore to survey local clinicians involved in brain death certification to identify specific areas of variability, if any, and to elicit information on how the testing process can be improved. Materials and Methods: An anonymous questionnaire was sent to all clinicians on the brain death certification roster in a tertiary neurosciences referral centre. This survey covered clinician demographics, evaluation of current and proposed resources to assist clinicians in certification, knowledge of the legislation governing brain death and organ procurement, technical performance of the brain death tests, and their views on the appropriate limits of physiological and biochemical preconditions for brain death testing. Results: We found significant variability in the conduct of brain death testing, especially in performing the caloric and apnoea tests. Of the existing resources to assist clinicians, written aide-memoires were the most popular. Respondents felt that bedside availability of a more detailed written description of the brainstem tests, and a formal accreditation course would be useful. There was wide variation in the limits of serum sodium and glucose, and the minimum core temperature and systolic blood pressures that respondents felt would preclude testing but we were able to identify thresholds at which the majority would be happy to proceed. We addressed the issues identified in our study by improving our written hospital brain death protocol, and designing an instructional course for clinicians involved in brain death certification. Conclusions: Our findings confirm that variability in the performance of brain death testing is indeed a universal phenomenon. Formal training appears desirable, but more importantly, clear and detailed protocols for testing should be made available at the bedside to assist clinicians. These protocols should be tailored to provide step-bystep instructions so as to avoid the inconsistencies in testing identified by this and other similar studies. Key words: Apnoea test, Brainstem death, Caloric test, Guidelines, Preconditions
    Type of Medium: Online Resource
    ISSN: 0304-4602
    Language: English
    Publisher: Academy of Medicine, Singapore
    Publication Date: 2007
    detail.hit.zdb_id: 2186627-2
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  • 5
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2011
    In:  Intensive Care Medicine Vol. 37, No. 8 ( 2011-8), p. 1285-1289
    In: Intensive Care Medicine, Springer Science and Business Media LLC, Vol. 37, No. 8 ( 2011-8), p. 1285-1289
    Type of Medium: Online Resource
    ISSN: 0342-4642 , 1432-1238
    RVK:
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2011
    detail.hit.zdb_id: 1459201-0
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  • 6
    Online Resource
    Online Resource
    Scientific Scholar ; 2013
    In:  Journal of Neurosciences in Rural Practice Vol. 04, No. S 01 ( 2013-12), p. S31-S34
    In: Journal of Neurosciences in Rural Practice, Scientific Scholar, Vol. 04, No. S 01 ( 2013-12), p. S31-S34
    Abstract: Background: Leucopenia has been reported after induction of thiopentone barbiturate therapy for refractory intracranial hypertension. However, the incidence and characterisitics are not well described. Aims: We performed a retrospective review to describe the incidence and characteristics of leucopenia after induction of thiopentone barbiturate therapy. Setting and Design: Our centre is a national referral centre for neurotrauma and surgery in a tertiary medical institution.Materials and Methods: We performed a retrospective review of all patients who received thiopentone barbiturate therapy for refractory intracranial hypertension during an 18 month period from January 2004 to June 2005 in our neurosurgical intensive care unit. Statistical Analysis Used: Statistical analysis was performed using SPSS version 15.0. All data are reported as mean ± standard deviation or median (interquartile range). The Chi square test was used to analyze categorical data and student t test done for comparison of means. For paired data, the paired t?test was used.-test was used. Results: Thirty eight (80.9%) out of 47 patients developed a decrease in white blood cell (WBC) count after induction of thiopentone barbiturate coma. The mean decrease in WBC from baseline to the nadir was 6.4 × 10 9 /L (P 〈 lt; 0.001) and occurred 57 (3-147) h after induction. The mean nadir WBC was 8.6 〈 3.6 × 10 9 /L. Three (6.4%) patients were leucopenic, with a WBC count of 2.8, 3.1, and 3.6 〈 10 9 /L. None of them were neutropenic. We did not find an association between decrease in WBC count and clinical diagnosis of infection. We did not find any association between possible risk factors such as admission GCS, maximum ICP prior to induction of barbiturate coma, APACHE II score, total duration and dose of thiopentone given, and decrease in WBC count. Conclusions: Decrease in WBC count is common, while development of leucopenia is rare after thiopentone barbiturate coma. Regular monitoring of WBC counts is recommended.
    Type of Medium: Online Resource
    ISSN: 0976-3147 , 0976-3155
    Language: English
    Publisher: Scientific Scholar
    Publication Date: 2013
    detail.hit.zdb_id: 2601242-X
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